Ua tsaug rau koj mus saib xwm txheej. Tus browser version koj siv tau muaj kev txhawb nqa CSS txwv. Rau qhov kev paub zoo tshaj plaws, peb xav kom koj siv qhov browser hloov tshiab (lossis xiam oob qhab sib haum hom hauv Internet Explorer). Nyob rau hauv lub sijhawm, los xyuas kom meej kev txhawb nqa txuas ntxiv, peb yuav muab lub vev xaib tsis muaj cov qauv thiab JavaScript.
Peptides thiab cov protein tau siv dav siv los kho ntau yam kabmob muaj ntau yam, tab sis lawv feem ntau yuav tsum tau txhaj tshuaj thiab lawv cov nyhuv luv luv. Cov kev ua tsis zoo no ntawm cov qauv ib txwm tuaj yeem tshem tawm nrog kev pab ntawm molecular engineering, tab sis qhov no yog ib txoj haujlwm nyuaj. Cov txheej txheem molecular engineering, xub pib thov cov tshuaj insulin thiab tam sim no ua tiav rau ob peb biopharmaceuticals, xav tau lub derivatization ntawm peptides thiab protein los ntawm fatty acids. Cov yam ntxwv tshwj xeeb thiab thaj chaw ntawm cov fatty acids fatty acids tuaj yeem muab cov cuab yeej muaj elongation sib txawv. Ib qho ntxiv, cov thev naus laus zis no yuav muab cov tshuaj peptide ntev, tej zaum yuav hloov cov kev faib tawm ntawm peptides, thiab yuav muaj peev xwm muaj peev xwm faib cov ntaub so ntswg. Nrog rau qhov muaj kev nyab xeeb ntawm cov roj ntsha thiab cov tshuaj zoo, cov thev naus laus zis muab cov kev pom tseeb rau peptide thiab cov protein tshuaj pom.
Txhua tus nqi yog net. Yuav tau muab ntxiv rau tom qab ntawm kev txheeb npe. Kev suav se yuav ua rau ntawm daim tshev nyiaj.
Muttenthader, M., King, GF, Adams, DJS, DJ & LOJ, PF sib tshuam hauv Peptide tshuaj nrhiav pom. Muttenthader, M., King, GF, Adams, DJS, DJ & LOJ, PF sib tshuam hauv Peptide tshuaj nrhiav pom.Muttenthader, M., Vajntxwv, Adams, DJS, DJ thiab Alevud, PF sib txawv hauv Peptide tshuaj nrhiav pom. Muttenthaler, M., Vajntxwv, GF, Adams, DJ & NOJ, PF 多肽药物发现的趋势. Muttenthaler, M., Vajntxwv, GF, Adams, DJ & JUDOOD, PFMuttenthader, M., Vajntxwv, Adams, DJS, DJ thiab Alevud, PF sib txawv hauv Peptide tshuaj nrhiav pom.National qhib cov tshuaj ib tug xibhwb. 20, 309-325 (2021). Qhov kev tshuaj xyuas no tsom rau cov kev tam sim no thiab yav tom ntej ntawm Peptide Tshuaj Xyuas Tshuaj.
Müller, Td, Blüher, M., Tschöp, Mh & Dimarchi, RD Anti-Kev Txawj Ntse: Kev Tawm Tsam thiab cov nyom. Müller, Td, Blüher, M., Tschöp, Mh & Dimarchi, RD Anti-Kev Txawj Ntse: Kev Tawm Tsam thiab cov nyom.Müller, Td, Blureen, M., MH thiab Dimarchi, RD anti-kev ua tshuaj nrhiav yeeb tshuaj: kev nce qib thiab cov nyom. Müller, Td, Blüher, M., Tschöp, Mh & Dimarchi, RD 抗肥胖药物发现: 进展和挑战. Müller, Td, Blüher, M., Tschöp, Mh & Dimarchi, RdMüller, Td, Blureen, M., MH thiab Dimarchi, RD anti-kev ua tshuaj nrhiav yeeb tshuaj: kev nce qib thiab cov nyom.National qhib cov tshuaj ib tug xibhwb. 21, 201-223 (2022). Qhov kev tshuaj xyuas no muaj kev pom rau cov teeb meem kev rog, tshwj xeeb tshaj yog cov tswv yim tshiab raws li peptides.
Strohl, wr fusion proteins kom txuas ntxiv lub neej ntawm biologics yog qhov zoo tshaj plaws rau kev ua haujlwm zoo. Biopharraceutics 29, 215-239 (2015).
Evans, M. li al. Adherence thiab kev pheej hmoo ntawm AntidiaBetic Cov tshuaj thiab koom nrog kev soj ntsuam thiab kev lag luam tshwm sim hauv cov neeg mob ntshav qab zib hom 2 rog rog rog. metabolism. 24, 377-390 (2022).
Polonsky, wh, Fisher, L., Hessler, D., Bruhn, D. & zoo tshaj plaws, JH cov tshuaj mob ib zaug rau cov ntshav qab zib ib zaug rau ntshav qab zib. Polonsky, wh, Fisher, L., Hessler, D., Bruhn, D. & zoo tshaj plaws, JH cov tshuaj mob ib zaug rau cov ntshav qab zib ib zaug rau ntshav qab zib.Polonsky wh, nuv ntses L., Hessler D., Beduner D., Bedune Jh tus neeg mob ntshav qab zib ib zaug ib zaug. Polonsky, wh, Fisher, L., Hessler, D., Bruhn, D. & Zoo Tshaj, Jh 患者对每周一次的糖尿病药物的看法. Polonsky, wh, Fisher, L., Hessler, D., Bruhn, D. & Zoo Tshaj, JhPolonsky wh, nuv ntses L., Hessler D., Beduner D., Brune D., thiab zoo tshaj plaws JH tus neeg mob ntshav qab zib ib zaug.rog rog rog. metabolism. 13, 144-149 (2011).
Hashimoto, M., KISO, KISO, KISO, KISO, Y. & Synthesis ntawm Palmitoyl derivin thiab lawv cov kev ua ub no roj ntsha. Hashimoto, M., KISO, KISO, KISO, KISO, Y. & Synthesis ntawm Palmitoyl derivin thiab lawv cov kev ua ub no roj ntsha.Hashimoto M., Kuso K., Kiso Y. thiab Muranishi S. synthesis ntawm Palmitoyl derivin thiab lawv cov kev ua haujlwm roj ntsha. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. 胰岛素棕榈酰衍生物的合成及其生物活性. Hashimoto, M., KISO, KISO, KISO, Y. & MURANISHI, S. Synthesis thiab kev ua si ntawm insulin Palmitoyl derivatives.Hashimoto M., Kiso K., Kiso Y. thiab Muranishi S. synthesis thiab kev ua haujlwm ntawm insulin Palmitoyl derivatives.Cov tshuaj reservoir 6, 171-176 (1989).
Kurtzhals, P. li al. Albumin Binding rau fatty acid-acylated insulin: kev sib txuam ntawm kev sib txuas lus zoo nkauj thiab kev sib txheeb ntawm lub sijhawm viv ncaus affinity thiab cov tshuaj insulin hauv vivo. biochem. J. 312, 725-731 (1995). Txoj haujlwm no yog thawj zaug los ua kom pom kev nce ntxiv ntawm lub neej ib nrab vim yog cov kev khi ntawm pepumin rau peptides muab tau los ntawm fatty acids.
Mejuch, T. & Waldmann, H. Synthesis ntawm lipidated protein. Mejuch, T. & Waldmann, H. Synthesis ntawm lipidated protein.Meyukh, T. thiab Waldmann, H. Synthesis ntawm lipidated protein. Mejuch, T. & Waldmann, H. 脂化蛋白质的合成. Mejuch, t. & Waldmann, h.Meyukh, T. thiab Waldmann, H. Synthesis ntawm lipidated protein.Bioconjugate. Tshuaj lom neeg. 27, 1771-1783 (2016).
Chen, B., Hnub, Y., Jarugumili, G., Wu, X. Cov Kab Mob Tawm Tsam Nyob Hauv Kev Pom Zoo Hauv Cell Chen, B., Hnub, Y., Jarugumili, G., Wu, X. Cov Kab Mob Tawm Tsam Nyob Hauv Kev Pom Zoo Hauv CellChen B., Hnub Yug Y., NiU J., Wu X., Wu X. WEPIDation nyob rau hauv signing thiab tus kab mob: muaj peev xwm tswj hwm. Chen, B., Hnub, Y., J., Jarugumili, GK & Wu, X. 细胞信号和疾病中的蛋白质脂化: 功能, 功能, 功能. Chen, B., Hnub, Y., Jarugumilli, G. Protein 脂化 Cov kab mob ntawm tes thiab kab mob, kev tswj hwm thiab kev tswj hwm.Chen B., Hnub Yug Y., NiU J., Wu X., Wu X. WEPIDation nyob rau hauv signing thiab tus kab mob: muaj peev xwm tswj hwm.Cytochistry. Biology 25, 817-831 (2018).
Richter, wf, bhansali, sg & morris, kuv cov neeg ua haujlwm txiav txim siab ntawm biotheAtics nqus hauv qab no SHUAV Richter, wf, bhansali, sg & morris, kuv cov neeg ua haujlwm txiav txim siab ntawm biotheAtics nqus hauv qab no SHUAVRichter, VF, Bhansali, SG thiab Morris, Kuv cov txheej txheem uas txiav txim siab qhov nqus ntawm cov neeg sawv cev hauv qab tom qab cov txheej txheem sib luag. Richter, wf, bhansali, sg & morris, kuv sc 给药后生物治疗药物吸收的机制决定因素. Richter, Wf, Bhansali, SG & Morris, Kuv Sc Richter, WF, Bhansali, SG & Morris, ME SC Механистические детерминанты абсорбции биотерапевтических препаратов после введения. Richter, wf, bhansali, sg & morris, kuv s sc mechaners txiav txim siab ntawm kev nqus ntawm cov tshuaj bihoiotrateutic tom qab kev tswj hwm.AAPS J. 14, 559-570 (2012).
Club, AkJ thiab al. Qhov cuam tshuam cuam tshuam rau kev nqus cov tshuaj insulin) kev cuam tshuam rau kev hloov pauv. J. DIABETES RE. 2018, 1205121 (2018).
Hildebrandt, P., SJRSEN, P., X, Birch, K. Diffusion thiab Setoft insulusion thiab Setcutane Ntse Cov neeg mob ntshav qab zib. Hildebrandt, P., SJRSEN, P., X, Birch, K. Diffusion thiab Setoft insulusion thiab Setcutane Ntse Cov neeg mob ntshav qab zib. Hildebrandt, P., SJRSEN, P., XACHSEN, SL, Birgeоределяюю изолимеризеделяюю из из подулюнннй ткани у пациентов с д абетом. Hildebrandt, P., Sojrsen, P., Xailch, K. Diffusion thiab Secchtization txiav txim siab insulin kev nqus los ntawm cov neeg mob ntshav qab zib. Hildebrandt, P., SJRSEN, P., Nielsen, SL, Birch, K. & Sestoft, L. 扩散和聚合决定了糖尿病患者皮下组织对胰岛素的吸收. Hildebrandt, P., Sojrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., SJSEN, P., XACHENT, SL, Bircheегция и посуцибцию посулию посулиюию подулиюию подулиюи подулжжжю тОююююю бкантов с д етом. Hildebrandt, P., SJRSEN, P., XIELSEN, SL, DISTOFT, K. & SETTOFT ARCECTHANY Cov neeg mob ntshav qab zib.scanning. J. Klin. tsev kuaj. nqis peev. 45, 685-690 (1985).
Mosekilde, E., Jensen, KS, Binder, C. Mosekilde, E., Jensen, KS, Binder, C.Mosekilte E, Jensen KS, Binder S, Pramming S, Phaj S, thiab Ua Qauv Kinetics ntawm subcutaneedfin insulin. Mosekilde, E., Jensen, KS, phau ntawv, C., Pramming, S. & To. Mosekilde, E., Jensen, KS, phau ntawv, C., pmam, s. & T.Mosekilte e, Jensen KS, Binder S, Pramming S, Programs A thiab Ua Qauv Kinetics ntawm SubcutaneSed Soluble insulin.J. Pharmacokinetics. Biopharmacy. 17, 67-87 (1989).
Kuna, M., Mahdi, F., Cha & Bidwell, GL III molecular loj modulates piopolymer elastin zoo li polypeide. Kuna, M., Mahdi, F., Cha & Bidwell, GL III molecular loj modulates piopolymer elastin zoo li polypeide. Kuna, M., Mahdi, F., cha & bidwell, GL III руеellируерикокираспнетику, биочаспние и отлложение отлложение биополимерного эластинопозогоозогоозогооогооого поля пля доставенного средства. Kuna, M., Mahdi, F., change, ar & bid iColecular loj forterition piopolymer elastin-zoo li polypetride rau kev xa tshuaj. Kuna, M., Mahdi, F., chade, ar & Bidwell, GL III 分子大小调节药物递送生物聚合物弹性蛋白样多肽的药代动力学, 生物分布和肾脏沉积. Kuna, M., Mahdi, F., charade, ar & BidWell, GL III Mrycher Polymer Polymer Polictin Elastic Elastein piv txwv li, faib roj ntsha 和鈥脏气度.Kuna, M., Mahdi, F., Chad, Ar thiab Bidwell, GL III. Pharmaconinetics, biodistribre thiab lub neej tso nyiaj ntawm biopolymicas-zoo li polypeptides modulating qhov loj ntawm cov molecule.Kev Tshaj Tawm Kawm Ntawv 8, 7923 (2018).
Harris, JM, Martin, ne & Modi, M. Pegylation: Ib qho txheej txheem tshiab rau kev hloov kho cov khw pharcephinininetics. Harris, JM, Martin, ne & Modi, M. Pegylation: Ib qho txheej txheem tshiab rau kev hloov kho cov khw pharcephinininetics. Harris, JM, Martin, Ne & Modi, M. подикацикациикации фаракимакокикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикикиМкакики. Harris, JM, Martin, ne & Modi, M. Pegylation: Ib qho txheej txheem tshiab rau kev hloov kho cov khw pharcephinininetics. Harris, JM, Martin, Ne & Modi, M. 聚乙二醇化: 一种改变药代动力学的新方法. Harris, JM, Martin, ne & Modi, M. 聚乙二感化: txoj kev tshiab ntawm kev hloov tshuaj. Harris, JM, Martin, Ne & Modi, M. пвыйли изоднению изменению иаракокиМакокики. Harris, JM, Martin, Ne & Modi, M. PeGylation: Ib txoj hauv kev tshiab rau kev hloov pauv chaw muag tshuaj.Soj ntsuam. Pharmaconinetics. 40, 539-551 (2001).
Elmerer, M. li al. Kev ntsuas ntawm cov pob txha pob txha pob txha pob txha pob txha pob txha thiab adipose los ntawm qhib Flow microperfusion. Yog lawm. J. Physiology. Endocrine. metabolism. 278, E352-E356 (2000).
Nelson, J. li al. Lub neej ntev ib nrab-lub neej ntawm albumin hauv tib neeg yuav tsum tau ua lub c-terminus. Sib txuas lus. biology. 3, 181 (2020).
Chowdhury, K. li al. FC receptor (FCRN) rau IGG txuam nrog cov tseem ceeb atherocompatibilibilibilibilibilibilibilibilibilibilibilibility nyuaj binds albumin thiab ntev nws lifespan. J. EXP. tshuaj kho mob. 197, 315-322 (2003).
Ntoo yeeb, RJ, Martinez, C., Laij Teb, X., Zhou, YYU, es Ntoo yeeb, RJ, Martinez, C., Laij Teb, X., Zhou, YYU, es Ntoo yeeb yaj kiab, RJ, Martinez, C., Liy, X. Ober, RJ, Martinez, C., Lai, X., Zhou, ES FCRY Receptor-Mediated IGG EXOCYTOSTOS: AN-MOLECEATT SOATCEATE). Ntoo yeeb, RJ, Martinez, C., Lai, X., Zhou, J., Zhou, ES, es, FCRN: 单分子水平的分析. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, Lawv Ntoo yeeb yaj kiab, RJ, Martinez, C., Lai, X., Zhou, FCпоиторедози ES, FCпоиит, FCLTцзTIONS оа овной олекулы. Ntoo yeeb, RJ, Martinez, C., Lai, X., Zhou, ESHE ReciTube IGG exocytosis, FRCN: ib leeg molecule-qib kev txheeb xyuas-theem.txheej txheem. National Academy of Science. kev tshawb fawb. US 101, 11076 (2004).
Nws, XM & Carter, DC piv cov qauv thiab chemistry ntawm tib neeg licumin. Nws, XM & Carter, DC piv cov qauv thiab chemistry ntawm tib neeg licumin.On, XM thiab Carter, DC piv cov qauv thiab chemistry ntawm tib neeg licumin. Nws, XM & Carter, DC 人血清白蛋白的原子结构和化学. Nws, XM & Carter, DC.On, XM thiab Carter, DC piv cov qauv thiab chemistry ntawm tib neeg licumin.Xwm 358, 209-215 (1992).
Curry, S., Brickow, H., P. & Franks, N. Crystal qauv ntawm tib neeg muaj fatty acid qhia tau ib qho chaw ua asymmetric qhia txog kev faib tawm. Curry, S., Brickow, H., P. & Franks, N. Crystal qauv ntawm tib neeg muaj fatty acid qhia tau ib qho chaw ua asymmetric qhia txog kev faib tawm.Curry S., Brickkow H., Cib P. Cov Qauv Crystal ntawm tib neeg cov lus muaj zog albumin hauv cov fatty acid qhia tau tias muaj kev faib tawm asymmetric. Curry, S., Mandelkow, H., Cib, P. & Franks, N. 与脂肪酸复合的人血清白蛋白的晶体结构揭示了结合位点的不对称分布. Curry, S., H., Cib, P. & Franks, N. Tus filtal fillex nrog fatty acids qhia tawm cov chaw ua haujlwm asymmetric qhia tawm ntawm cov chaw.Curry S., Brickkow H., Cib P. thiab Franks N. Cov Frystal qauv albumin hauv cov fattex nrog cov filty acids uas qhia txog kev faib tawm asymmetric.NAT. qauv. Biology 5, 827-835 (1998). Daim ntawv no nthuav qhia cov qauv qauv ntawm kev khi ntawm cov roj fatty acids rau ntshav albumin.
Irby, D., du, C. & Li, F. Lipid-yeeb tshuaj conjugate rau kev xa tshuaj kom zoo nkauj. Irby, D., du, C. & Li, F. Lipid-yeeb tshuaj conjugate rau kev xa tshuaj kom zoo nkauj.Irby, Du, K. thiab LI, F. Lipid-yeeb tshuaj conjugates rau kev xa tshuaj kom zoo dua. Irby, D., du, C. & Li, F. Lipid-yeeb tshuaj conjugate rau txhim kho kev siv tshuaj. Irby, D., du, C. & Li, F. Lipid-yeeb tshuaj conjugate rau txhim kho kev siv tshuaj.Irby, D., du, K. thiab Li, F. Lipid-yeeb tshuaj conjugate rau kev xa tshuaj kom zoo dua.Biochemistry 14, 1325-1338 (2017).
Porchilin VP nyuam qhuav hloov tshiab hauv thaj teb ntawm liposomes ua tus nqa tshuaj yeeb. National qhib cov tshuaj ib tug xibhwb. 4, 145-160 (2005).
Bhat, M., JATYAN, R., A., Mahato, Ri & ChitKara, D. Cov kev sib tw ntawm Filty Acid conjugated kho. Bhat, M., JATYAN, R., A., Mahato, Ri & ChitKara, D. Cov kev sib tw ntawm Filty Acid conjugated kho.Bhat, M., JATYAN, R., A., Mahato, Ri thiab ChitKara, D. Cov kev sib tw ntawm Filty Acid conjugated kho. Bhat, M., JATYAN, R., A., Mahato, Ri & ChitKara, D. 脂肪酸共轭疗法的机遇和挑战. Bhat, M., JATYAN, R., A., Mahato, Ri & ChitKara, D. fatty acid 共续电影的机遇和 sib tw.Bhat M., JATYAN R., Mahato Ri thiab ChitKara D. Kev muaj peev xwm thiab cov nyom ntawm cov roj fatty acid conjugation kho.Tshuaj lom neeg. Lipics Lipids 236, 105053 (2021).
Smith, R. & TANFORD, C. Hydrophobicity ntawm cov saw ntev n-alkyl carboxylic acids, raws li ntsuas los ntawm lawv cov kev faib tawm ntawm heptane thiab aqueous daws. Smith, R. & TANFORD, C. Hydrophobicity ntawm cov saw ntev n-alkyl carboxylic acids, raws li ntsuas los ntawm lawv cov kev faib tawm ntawm heptane thiab aqueous daws.Smith, R. thiab TANFORD, K. Hydrophobicity ntawm ntev-saw n-alkylcarboxylic acidsured los ntawm lawv cov kev faib tawm ntawm heptane thiab aqueous daws. Smith, R. & TANFORD, C. 长链正烷基羧酸的疏水性, 通过它们在庚烷和水溶液之间的分布来测量. Smith, R. & TANFORD, C. Lub Hydrophobicity ntawm 长链正 Alkylcarboxylate, ntsuas los ntawm lawv cov kev faib tawm ntawm hydrogen peroxide thiab aqueous daws.Smith, R. thiab TANFORD, K. Hydrophobicity ntawm ntev-saw n-alkylcarboxylic acidsured los ntawm lawv cov kev faib tawm ntawm heptane thiab aqueous daws.txheej txheem. National Academy of Sciences. Science US 70, 289 (1973).
Liu, J. li al. Thaum-txhua lub lim tiam tshawb pom ntawm semaglutide analog ntawm glucagag-zoo li peptide-1 (GPP-1). J. Tshuaj. Tshuaj lom neeg. 58, 7370-7380 (2015). Qhov kev ua haujlwm no tau qhia thawj zaug txog thawj zaug uas tau siv ib zaug ib zaug lim piam roj ntsha ua rau cov hau kev.
ØSTERGAART, S. LI AL. Cov nyhuv ntawm tib neeg pyy3-36 dibasic fatty acid acylation ntawm mini-npua y2 receptor kev ua haujlwm thiab ib nrab-lub neej. kev tshawb fawb. Tshaj tawm 11, 21179 (2021). Cov lus qhia no qhia txog qhov tseem ceeb ntawm cov tseem ceeb ntawm cov rog acid txoj hauj lwm, txuas thiab caj qaum ruaj khov hauv kev txhim kho ntev ib nrab-lub neej pyy analogs.
ENSENAT-VASH, R. LI AL. Nkag mus rau hauv mentrationoylated peptides hla cell membrane tau pom ncaj qha siv cov fluorescence microscopy. Iubmb lub neej 54, 33-36 (2002).
Nelson, AR, Bood, L., Allbritton, NL & Sims, CE myristoyl-raws li kev thauj mus los ntawm peptides ua cov khoom muaj sia. Nelson, AR, Bood, L., Allbritton, NL & Sims, CE myristoyl-raws li kev thauj mus los ntawm peptides ua cov khoom muaj sia.Nelson Ar, Bolland L, Allbritton NL. Thiab sims SE peptide thauj hauv cov muaj sia nyob yog raws li myristoyl. Nelson, AR, Bood, L., Allbritton, NL & Sims, CE 基于肉豆蔻酰的肽转运到活细胞中. Nelson, AR, Boodland, L., Allbritton, NL & Sims, CE.Nelson, AR, Boodland, L., Albritton, NL. Thiab sims, qab thauj ntawm myristoyl-raws peptides rau hauv cov ciaj sia.Biochemistry 46, 14771-14781 (2007).
KABANOV, AV, LEVASHOV, AV & ALAKHOV, VY Lipid kev hloov kho ntawm cov protein thiab lawv cov kev thauj mus los. KABANOV, AV, LEVASHOV, AV & ALAKHOV, VY Lipid kev hloov kho ntawm cov protein thiab lawv cov kev thauj mus los.Kabanov AV, LAVASHOV AV, ALAKHOV V.YU. Lipid kev hloov kho ntawm cov protein thiab lawv cov kev thauj mus los. KABANOV, AV, LEVASHOV, AV & ALAKHOV, VY 蛋白质的脂质修饰及其膜转运. Kabanov, av, Leverahaov, Av & Alakhov, VyKabanov AV, LAVASHOV AV, ALAKHOV, Lipid kev hloov kho ntawm cov protein thiab lawv cov kev thauj mus los.Protein engineering. Dec. Searl. 3, 39-42 (1989).
Gao, X., Mazièère, Ad, BEAR, R., klumperman, J. & Hannoush, rn, rn fatances txhim kho ntawm lub cystine-pob caus ntawd peptide. Gao, X., Mazièère, Ad, BEAR, R., klumperman, J. & Hannoush, rn, rn fatances txhim kho ntawm lub cystine-pob caus ntawd peptide.Gao, X., Tshaj Tawm, AD, Byrd, JLumperman, J. thiab Hannoosh, Rn Hannesy Cellular txhim kho ntawm peptide nrog lub voj voos. Gao, X., Mazière, Ad, BEAR, R., klumperman, J. & Hannoush, RN 脂肪酰化增强了胱氨酸结肽的细胞内化和胞质分布. Gao, X., Mazièère, Ad, BEAR, R., klumperman, J. & Hannoush, RN.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. thiab Hannoosh, rn Hatiskas Kev faib khoom sab hauv thiab cytoplasmic faib ntawm cystine peptides.Raug mob 24, 103220 (2021).
Baker, em li al. Ib nrab-lub neej kev hloov kho ntawm yy3-36 peptide rau ncaj qha rau receptor-mediated sab hauv. Moore. tshuaj kho mob. 16, 3665-3677 (2019).
Mäde, v., Bellmann-mob, K., Kaiser, A., tus neeg muaj rog, ag txoj hauj lwm muaj zog cuam tshuam rau tus qauv tib neeg ntawm tib neeg panycreic polypepride analogues. Mäde, v., Bellmann-mob, K., Kaiser, A., tus neeg muaj rog, ag txoj hauj lwm muaj zog cuam tshuam rau tus qauv tib neeg ntawm tib neeg panycreic polypepride analogues.Ua, W., Bellmann-MobileN, K. K. Txawm li cas los, v., Bellmann-tus neeg muaj mob, K., Kaiser, A., Meil ​​Er, J. & Beck-Dickinger, AG 脂肪酸的位置和长度强烈影响人胰腺多肽类似物的受体选择性模式. , V., Bellmann-mob, K., Kaiser, A., Meil ​​Er, J. & Beck-Breinger, AGUa, W., Bellmann-Mob, K., Kaiser, A., ag txoj hauj lwm muaj zog ntawm tib neeg pancreatic analog polypeptide receptors.Himmedchem 9, 2463-2474 (2014).
Aleksopoulou, F. li al. Daim Metabolite lipid PRRPPTSOLITE PRRPP31 yog ib tug ntev-ua si dual GPR10 thiab NPFF2 receptor agonist nrog lub zog poob siab. kev tshawb fawb. Daim ntawv qhia 12, 1696 (2022). Txoj kev tshawb no nthuav dav cov teeb meem sib txawv ntawm cov saw mono-thiab diacid sab.
Poulsen, K. li al. Kev txhim kho muaj yim ntawm cov laus ruaj khov ntawm y2 receptor peptide Pyy3-36. tshuaj kho mob. Cia Lub Tank. 38, 1369-1385 (2021).
Conde-Frieboes, K. li al. Kev cim thiab cim ntawm hauv Vitro thiab Vivo analogues ntawm kev ua yeeb yam ntev thiab xaiv Melanocortin 4 recator (alpha-melha-msh). J. Tshuaj. Tshuaj lom neeg. 55, 1969-1977 (2012).
Ramirez-Andersen, HS li al. Ntev ua rau tib neeg kev loj hlob hormone analogues ua txhaum rau tsis-sib cav albumin. Bioconjugate. Tshuaj lom neeg. 29, 3129-3143 (2018).
Madsen, K. li al. Cov qauv-kev ua si sib raug zoo thiab elongation ntawm kev ua yeeb yam ntev-nyiam peptide-1 derivatives-1 sterivatives: qhov tseem ceeb ntawm cov roj filty acid ntev, polarity, thiab ntim. J. Tshuaj. Tshuaj lom neeg. 50, 6126-6132 (2007).
Wieczorek, B., spetzler, JC, KRuse, T., Lindow E, L. & Kofoed, J. Ob-acylated GLP-1 derivatives. Wieczorek, B., spetzler, JC, KRuse, T., Lindow E, L. & Kofoed, J. Ob-acylated GLP-1 derivatives. Wieczorek, B., spetzler, jc, kruse, T., Lindoth, L. & Kofжed, J. дважиллилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилилярованные Wieczorek, B., Spetzler, JRuse, JRuse, T., Lindowth, L. & Kofoed, J. DoBly Acylated Derivatives ntawm GLP-1. Wieczorek, B., spetzler, jc, kruse, T., Lindoth, L. & Kofoed, J. GLP-1 衍生物. Wieczorek, B., spetzler, jc, kruse, T., Lindoth, L. & Kofoed, J. GLP-1 衍生物. Wieczorek, B., spetzler, JC, KROUSE, T., Lindoth, L. & Kofoed, J. доацилированные поизводные GPP-1. Wieczorek, B., spetzler, jc, kruse, T., LindoTH, L. & Kofoed, J. Dia cov derivatives ntawm GLP-1.Teb chaws Asmeskas Patent Wo2012 / 140117 (2012).
Cov tub ntxhais hluas, P.-YU. Tos. Muaj zog, ntev-ua yeeb yam GLP-1 Analogs tsim rau kev hloov pauv hloov pauv raws li microstructure. txheej txheem. National Academy of Science. kev tshawb fawb. Tebchaws Asmeskas 113, 4140-4145 (2016).
Royalty, JE, Konradsen, G., Eskerod, O., BS Kev tshawb nrhiav kev nyab xeeb, thiab tshuaj papes ntawm kev tshawb nrhiav ntev ntev kawm. Royalty, JE, Konradsen, G., Eskerod, O., BS Kev tshawb nrhiav kev nyab xeeb, thiab tshuaj papes ntawm kev tshawb nrhiav ntev ntev kawm.Royalty, JE, Konradsen, G., Hma, tus hma, ua kom muaj kev nyab xeeb, thiab tshuaj paps,, JE, Konradsen, G., Eskerod, O., Wulff, BS & hansen, BS α-msh 类似物在健康超重和肥胖患者中的安全性, 耐受性, 药代动力学和药效学研究科目., Je, Konradsen, G., Wullerod, O., Hansen, BS Siv ib zaug thiab ntau npaum li cas ntev α, 药代报学学和药效学研究科目.Royalty, JE, Konradsen, G., Hma, tus hma, ua kom muaj kev nyab xeeb, kev ua kom muaj kev nyab xeeb, msg analogues nyob rau hauv kev noj qab haus huv thiab rog. Kinetics thiab pharapacodynamics.J. Clin. Pharapacynamics. 54, 394-404 (2014).
Lau, J., Kruse, T., Lindow ES, Linderoth, L. & Tøgersen, H. Dab Neeg zoo gluogues. Lau, J., Kruse, T., Lindow ES, Linderoth, L. & Tøgersen, H. Dab Neeg zoo gluogues.Lau, J., KRuse, T., Lindow ESNEY, L. thiab togersen, H. Tshiab gluogues. Lau, Y., Kruse, T., Lindow, L. & Tongersen, H. 新型胰高血糖素类似物. Lau, J., F., KRuse, T., Lindow ESNEEG, L. & Tøgersen, H.Lau, J., T., T., Lindow E, L. thiab togersen, H. Tshiab gluogues.Teb chaws Asmeskas Patent Wo2011 / 117416 A1 (2011).
Pawg ntseeg, BP li al. Lipidation ntawm peptides cov qauv sib xyaw kom txhim kho kev muaj nuj nqi roj ntsha. Moore. metabolism. 2, 468-479 (2013). Qhov kev ua haujlwm no qhia tau lub luag haujlwm ntawm cov roj ntsha ua kom muaj roj nyob hauv kev txiav txim siab cov qauv kev ruaj ntseg thiab kev sib tsoo ntawm peptide cov tshuaj tiv thaiv.
Koskun T. li al. Ly3298176, tus tshiab dual gip thiab GLP-1 Cov Lus Qhia Txog Kev Kho Mob Hom 2 Ntshav Qab Zib Hom 2: Los ntawm kev paub txog cov ntawv pov thawj hauv lub tswvyim. Moore. metabolism. 18, 3-14 (2018). Daim ntawv no nthuav qhia tus qauv tsim los ntawm thawj thawj cov roj ntsha acid-muab tau los ntawm GLP-1 / GIP Co-Agonist rau ib zaug-txhua lub lim tiam hauv chaw kho mob.
Kjeldsen, TB li al. Molecular Engineering ntawm Icodec insulin, thawj zaug ib zaug-txhua lub limtiam acylated insulin analog hauv tib neeg. J. Tshuaj. Tshuaj lom neeg. 64, 8942-8950 (2021). Daim ntawv no nthuav qhia thawj qhov kev txhim kho fatty acid muab tau nyiaj los ntawm cov insulin rau ib zaug ua txhua lub limtiam.
Van Wittelostein, SB li al. Noglycolipids rau kev ua yeeb yam ntev - tus kheej sib sau ua ke ntawm genucagon-zoo li pepumin-binding cov khoom thiab siab Vivo potency. Moore. tshuaj kho mob. 14, 193-205 (2017).
Zorzi, A., MBRIDERORP, WILBS, J., Heylated Heptapeide Binds Albumin nrog cov chaw ua haujlwm siab ntev. Zorzi, A., MBRIDERORP, WILBS, J., Heylated Heptapeide Binds Albumin nrog cov chaw ua haujlwm siab ntev.Zorzi, A., MBRIDERORP, WILBS, J., Dale, K. thiab nws siv los ua lub siab ua rau muaj peptide ntev. Zorzi, A., Mogrendorp, sj, wilbs, J., Hyle, K. & Heinis, C. & Heinis, C. Zorzi, A. Khoos dev, Wilbs, Y., Hermis, K. & Heinis, C. 鎄化七 Peptide 以高亲和力设计白白约筒, 使用于设计手机长整线等.Zorzi, A., MBRIDERORP, WILBS, J., Dale, K. thiab Heys, S. Cov ntawv cim rau cov khoom xa mus ntev peptide.NAT. Sib Tham 8, 16092 (2017).