Ua tsaug rau koj tuaj xyuas Nature.com. Qhov browser version koj siv tau txwv CSS kev txhawb nqa. Rau qhov kev paub zoo tshaj plaws, peb xav kom koj siv qhov browser tshiab (lossis lov tes taw Compatibility Hom hauv Internet Explorer). Nyob rau lub sijhawm no, txhawm rau ua kom muaj kev txhawb nqa txuas ntxiv, peb yuav ua rau lub xaib tsis muaj qauv thiab JavaScript.
Peptides thiab cov proteins tau dav siv los kho ntau yam kab mob, tab sis lawv feem ntau yuav tsum tau txhaj tshuaj thiab lawv cov nyhuv yog luv luv. Cov kev tsis txaus ntawm cov qauv hauv ib txwm tuaj yeem raug tshem tawm nrog kev pab ntawm molecular engineering, tab sis qhov no yog ib txoj haujlwm nyuaj. Molecular engineering cov txheej txheem, Ameslikas siv rau insulin thiab tam sim no ua tiav siv rau ntau yam biopharmaceuticals, xav tau derivatization ntawm peptides thiab proteins los ntawm fatty acids. Cov yam ntxwv tshwj xeeb thiab qhov chaw ntawm cov roj fatty acids txuas tuaj yeem muab cov txheej txheem elongation sib txawv. Tsis tas li ntawd, cov thev naus laus zis no tuaj yeem muab sijhawm ntev ib nrab ntawm lub neej tom qab kev tswj hwm qhov ncauj ntawm cov tshuaj peptide, tuaj yeem hloov pauv kev faib tawm ntawm peptides, thiab tej zaum yuav muaj peev xwm ua rau cov ntaub so ntswg. Nrog rau kev nyab xeeb ntawm cov roj fatty acids thiab cov khoom siv tshuaj muaj txiaj ntsig zoo, cov cuab yeej no muab ntau txoj hauv kev rau peptide thiab cov tshuaj protein nrhiav pom.
Txhua tus nqi yog net. VAT yuav muab ntxiv tom qab ntawm kev them nyiaj. Kev suav se yuav raug ua thaum lub tshev tawm.
Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Trends in peptide drug discovery. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Trends in peptide drug discovery.Muttenthaler, M., King, GF, Adams, DJ thiab Alevud, PF Trends in peptide drug discovery. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF 多肽药物发现的趋势. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PFMuttenthaler, M., King, GF, Adams, DJ thiab Alevud, PF Trends in peptide drug discovery.Teb Chaws Qhov qhib ntawm tus xibhwb tshuaj. 20, 309–325 (2021). Qhov kev tshuaj xyuas no tsom mus rau qhov tam sim no thiab yav tom ntej ntawm kev tshawb pom tshuaj peptide.
Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-obesity drug discovery: kev nce qib thiab kev sib tw. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-obesity drug discovery: kev nce qib thiab kev sib tw.Müller, TD, Blucher, M., Chop, MH thiab DiMarchi, RD Anti-obesity tshuaj nrhiav pom: kev nce qib thiab cov nyom. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD 抗肥胖药物发现：进展和挑战. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RDMüller, TD, Blucher, M., Chop, MH thiab DiMarchi, RD Anti-obesity tshuaj nrhiav pom: kev nce qib thiab cov nyom.Teb Chaws Qhov qhib ntawm tus xibhwb tshuaj. 21, 201–223 (2022). Qhov kev tshuaj xyuas no muab kev nkag siab txog cov teeb meem ntawm kev rog, tshwj xeeb tshaj yog cov tswv yim tshiab raws li peptides.
Strohl, WR Fusion proteins los txuas ntxiv ib nrab-lub neej ntawm biologics raws li lub tswv yim zoo tshaj plaws rau biologics. Biopharmaceutics 29, 215–239 ​​​​(2015).
Evans, M. et al. Kev ua raws thiab kev pheej hmoo ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib thiab koom nrog kev kho mob thiab kev lag luam hauv cov neeg mob ntshav qab zib hom 2: kev tshuaj xyuas cov ntaub ntawv. ntshav qab zib rog. metabolism. 24, 377–390 (2022).
Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Tus neeg mob qhov kev xav ntawm cov tshuaj ib zaug ib lim piam rau ntshav qab zib. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Tus neeg mob qhov kev xav ntawm cov tshuaj ib zaug ib lim piam rau ntshav qab zib.Polonsky WH, Fisher L., Hessler D., Brune D., thiab Best JH A tus neeg mob qhov kev xav ntawm cov tshuaj noj ntshav qab zib ib zaug ib lim piam. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH 患者对每周一次的糖尿病药物的看法. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JHPolonsky WH, Fisher L., Hessler D., Brune D., thiab Best JH Tus neeg mob kev nkag siab txog cov tshuaj ntshav qab zib ib zaug ib lim piam.ntshav qab zib rog. metabolism. 13, 144–149 (2011).
Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis of palmitoyl derivatives of insulin and their biological activities. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis of palmitoyl derivatives of insulin and their biological activities.Hashimoto M., Takada K., Kiso Y. thiab Muranishi S. Synthesis of palmitoyl derivatives of insulin and their biological activity. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. 胰岛素棕榈酰衍生物的合成及其生物活性. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis and biological act of insulin palmitoyl derivatives.Hashimoto M., Takada K., Kiso Y. thiab Muranishi S. Synthesis and biological act of insulin palmitoyl derivatives.tshuaj reservoir 6, 171–176 (1989).
Kurtzhals, P. et al. Albumin khi rau fatty acid-acylated insulin: tus cwj pwm ntawm ligand-protein kev sib cuam tshuam thiab kev sib raug zoo ntawm kev sib raug zoo ntawm kev sib raug zoo thiab lub sijhawm ua haujlwm insulin hauv vivo. biochem. J. 312, 725–731 (1995). Qhov kev ua haujlwm no yog thawj zaug ua kom pom qhov nce hauv ib nrab ntawm lub neej vim yog kev sib txuas ntawm albumin rau peptides tau los ntawm cov roj fatty acids.
Mejuch, T. & Waldmann, H. Synthesis of lipidated proteins. Mejuch, T. & Waldmann, H. Synthesis of lipidated proteins.Meyukh, T. and Waldmann, H. Synthesis of lipidated proteins. Mejuch, T. & Waldmann, H. 脂化蛋白质的合成. Mej, T. & Waldmann, H.Meyukh, T. and Waldmann, H. Synthesis of lipidated proteins.Bioconjugate. Tshuaj. 27, 1771–1783 (2016).
Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation hauv cell signaling thiab kab mob: kev ua haujlwm, kev tswj hwm, thiab kev kho mob. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation hauv cell signaling thiab kab mob: kev ua haujlwm, kev tswj hwm, thiab kev kho mob.Chen B., Sun Y., Niu J., Jarugumilli GK thiab Wu X. Protein lipidation hauv cell signaling thiab kab mob: kev ua haujlwm, kev tswj hwm, thiab kev kho mob muaj peev xwm. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein 脂化 hauv xov tooj ntawm tes thiab kab mob: kev ua haujlwm, kev tswj hwm thiab kev kho mob.Chen B., Sun Y., Niu J., Jarugumilli GK thiab Wu X. Protein lipidation hauv cell signaling thiab kab mob: kev ua haujlwm, kev tswj hwm, thiab kev kho mob muaj peev xwm.cytochemistry. Biology 25, 817–831 (2018).
Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants ntawm biotherapeutics absorption tom qab SC kev tswj hwm. Richter, WF, Bhansali, SG & Morris, ME Mechanistic determinants ntawm biotherapeutics absorption tom qab SC kev tswj hwm.Richter, VF, Bhansali, SG thiab Morris, ME Mechanisms uas txiav txim siab nqus cov tshuaj biotherapeutic tom qab kev tswj hwm subcutaneous. Richter, WF, Bhansali, SG & Morris, ME SC 给药后生物治疗药物吸收的机制决定因素. Richter, WF, Bhansali, SG & Morris, ME SC Richter, WF, Bhansali, SG & Morris, ME SC Механистические детерминанты абсорбции биотерапевтических препаратов после вве . Richter, WF, Bhansali, SG & Morris, ME SC Mechanistic determinants ntawm absorption ntawm biotherapeutic tshuaj tom qab kev tswj hwm.AAPS J. 14, 559–570 (2012).
Gradel, AKJ et al. Cov yam ntxwv cuam tshuam rau subcutaneous insulin nqus: cuam tshuam rau kev hloov pauv. J. Diabetes Res. 2018, 1205121 (2018).
Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion thiab polymerization txiav txim siab qhov nqus ntawm insulin los ntawm cov ntaub so ntswg subcutaneous hauv cov neeg mob ntshav qab zib. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion thiab polymerization txiav txim siab qhov nqus ntawm insulin los ntawm cov ntaub so ntswg subcutaneous hauv cov neeg mob ntshav qab zib. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. пациентов с диабетом. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion thiab polymerization txiav txim siab kev nqus ntawm insulin los ntawm cov ntaub so ntswg subcutaneous hauv cov neeg mob ntshav qab zib. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. nrog диабетом. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion thiab aggregation txiav txim siab subcutaneous insulin absorption hauv cov neeg mob ntshav qab zib.luam theej duab. J. Klin. chav kuaj. nqis peev. 45, 685–690 (1985).
Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modeling absorption kinetics of subcutaneous injected soluble insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modeling absorption kinetics of subcutaneous injected soluble insulin.Mosekilde E, Jensen KS, Binder S, Pramming S, thiab Thorsteinsson B. Ua qauv rau kev nqus kinetics ntawm subcutaneous soluble insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. 模拟皮下注射可溶性胰岛素的吸收动力学. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B.Mosekilde E, Jensen KS, Binder S, Pramming S, thiab Thorsteinsson B. Ua qauv rau kev nqus kinetics ntawm subcutaneously tswj cov tshuaj soluble insulin.J. Pharmacokinetics. biopharmacy. 17, 67–87 (1989).
Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecular size modulates pharmacokinetics, biodistribution, thiab raum deposition ntawm cov tshuaj xa biopolymer elastin zoo li polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecular size modulates pharmacokinetics, biodistribution, thiab raum deposition ntawm cov tshuaj xa biopolymer elastin zoo li polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Размер молекулы модулирует фармакокинетику, биораспределение и ка отложнипе биополимерного эластиноподобного полипептида для доставки лекарственного средства. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecular size modulates pharmacokinetics, biodistribution, thiab lub raum deposition ntawm biopolymeric elastin-zoo li polypeptide rau kev xa tshuaj. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III分子大小调节药物递送生物聚合物弹性蛋白样多肽的药代动力学、生物分布和肯。 Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecule 大小名行电影送送biological polymer elastic protein sample 多如乐的药代报学学、biological distribution 和鈥脦。Kuna, M., Mahdi, F., Chad, AR and Bidwell, GL III. Pharmacokinetics, biodistribution thiab lub raum deposition ntawm biopolymeric elastin zoo li polypeptides modulating qhov loj ntawm cov molecule.Science Report 8, 7923 (2018).
Harris, JM, Martin, NE & Modi, M. Pegylation: cov txheej txheem tshiab rau kev hloov kho pharmacokinetics. Harris, JM, Martin, NE & Modi, M. Pegylation: cov txheej txheem tshiab rau kev hloov kho pharmacokinetics. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый процесс модификации фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: cov txheej txheem tshiab rau kev hloov kho pharmacokinetics. Harris, JM, Martin, NE & Modi, M. 聚乙二醇化：一种改变药代动力学的新方法 Harris, JM, Martin, NE & Modi, M. 聚乙二感化: txoj kev hloov tshuaj tshiab. Harris, JM, Martin, NE & Modi, M. Пегилирование: новый подход к изменению фармакокинетики. Harris, JM, Martin, NE & Modi, M. Pegylation: ib txoj hauv kev tshiab los hloov cov tshuaj pharmacokinetics.kho mob. Pharmacokinetics. 40, 539–551 (2001).
Elmerer, M. et al. Kev ntsuas ntawm interstitial albumin hauv tib neeg cov leeg pob txha thiab cov ntaub so ntswg adipose los ntawm kev qhib microperfusion. Yog lawm. J. Physiology. endocrine. metabolism. 278, E352-E356 (2000).
Nelson, J. et al. Qhov ntev ib nrab-lub neej ntawm albumin nyob rau hauv tib neeg yuav tsum muaj qhov tsis zoo C-terminus. sib txuas lus. biology. 3, 181 (2020).
Chowdhury, K. et al. Fc receptor (FcRn) rau IgG cuam tshuam nrog qhov loj histocompatibility complex khi albumin thiab ncua nws txoj sia. J. Exp. tshuaj kho mob. 197, 315–322 (2003).
Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis of IgG as mediated by the receptor, FcRn: an analysis at the single-molecule level. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Экзоцитоз IgG, опосредованный рецептором FcRn: анализ на уровне одной мол. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES FcRn receptor-mediated IgG exocytosis: ib leeg-molecule tsom xam. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES 受体介导的IgG 胞吐作用，FcRn：单分子水平的分析. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, Экзоцитоз IgG, опосредованный рецептором ES, FcRn: анализ на уровне одлукей Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES receptor-mediated IgG exocytosis, FcRn: ib leeg molecule-level analysis.txheej txheem. National Academy ntawm Science. kev kawm. US 101, 11076 (2004).
Nws, XM & Carter, DC Atomic qauv thiab chemistry ntawm tib neeg cov ntshav albumin. Nws, XM & Carter, DC Atomic qauv thiab chemistry ntawm tib neeg cov ntshav albumin.Ntawm, XM thiab Carter, DC Atomic qauv thiab chemistry ntawm tib neeg cov ntshav albumin. Nws, XM & Carter, DC 人血清白蛋白的原子结构和化学. He, XM & Carter, DC.Ntawm, XM thiab Carter, DC Atomic qauv thiab chemistry ntawm tib neeg cov ntshav albumin.Xwm Txheej 358, 209–215 (1992).
Curry, S., Mandelkow, H., Cib, P. & Franks, N. Crystal qauv ntawm tib neeg serum albumin complexed nrog fatty acid qhia ib qho asymmetric faib ntawm cov chaw khi. Curry, S., Mandelkow, H., Cib, P. & Franks, N. Crystal qauv ntawm tib neeg serum albumin complexed nrog fatty acid qhia ib qho asymmetric faib ntawm cov chaw khi.Curry S., Mandelkow H., Brick P. thiab Franks N. Cov qauv siv lead ua ntawm tib neeg cov ntshav albumin nyob rau hauv complex nrog fatty acid qhia tau hais tias ib qho asymmetric faib ntawm cov chaw khi. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Curry, S., Mandelkow, H., Cib, P. & Franks, N. Cov qauv siv lead ua ntawm tib neeg cov ntshav dawb protein complex nrog fatty acids qhia ib qho asymmetric faib ntawm cov chaw khi.Curry S., Mandelkow H., Brick P. thiab Franks N. Cov qauv siv lead ua ntawm tib neeg cov ntshav albumin nyob rau hauv complex nrog fatty acids qhia tau hais tias ib qho asymmetric faib ntawm cov chaw khi.Nat. qauv. Biology 5, 827–835 (1998). Daim ntawv no nthuav tawm cov qauv hauv paus ntawm kev khi ntawm fatty acids rau serum albumin.
Irby, D., Du, C. & Li, F. Lipid-drug conjugate rau kev txhim kho kev xa tshuaj. Irby, D., Du, C. & Li, F. Lipid-drug conjugate rau kev txhim kho kev xa tshuaj.Irby, D., Du, K. thiab Li, F. Lipid-drug conjugates rau kev txhim kho kev xa tshuaj. Irby, D., Du, C. & Li, F. Lipid-drug conjugate rau txhim kho kev xa tshuaj. Irby, D., Du, C. & Li, F. Lipid-drug conjugate rau txhim kho kev xa tshuaj.Irby, D., Du, K. thiab Li, F. Lipid-drug conjugate rau txhim kho kev xa tshuaj.Biochemistry 14, 1325–1338 (2017).
Torchilin VP Tsis ntev los no tau nce qib hauv thaj tsam liposomes ua cov neeg nqa tshuaj. Teb Chaws Qhov qhib ntawm tus xibhwb tshuaj. 4, 145–160 (2005).
Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Lub Sijhawm thiab cov teeb meem ntawm fatty acid conjugated therapeutics. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Lub Sijhawm thiab cov teeb meem ntawm fatty acid conjugated therapeutics.Bhat, M., Jatyan, R., Mittal, A., Mahato, RI thiab Chitkara, D. Lub Sijhawm thiab cov teeb meem ntawm fatty acid conjugated therapeutics. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. 脂肪酸共轭疗法的机遇和挑战. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Fatty acid 共续电影的机遇和 kev sib tw.Bhat M., Jatyan R., Mittal A., Mahato RI thiab Chitkara D. Muaj peev xwm thiab cov teeb meem ntawm fatty acid conjugation therapy.Tshuaj. Physics Lipids 236, 105053 (2021).
Smith, R. & Tanford, C. Hydrophobicity ntawm cov saw ntev n-alkyl carboxylic acids, raws li ntsuas los ntawm lawv qhov kev faib tawm ntawm heptane thiab aqueous daws. Smith, R. & Tanford, C. Hydrophobicity ntawm cov saw ntev n-alkyl carboxylic acids, raws li ntsuas los ntawm lawv qhov kev faib tawm ntawm heptane thiab aqueous daws.Smith, R. thiab Tanford, K. Hydrophobicity ntawm cov saw ntev n-alkylcarboxylic acids ntsuas los ntawm lawv qhov kev faib tawm ntawm heptane thiab aqueous daws. Smith, R. & Tanford, C. C. Smith, R. & Tanford, C. Lub hydrophobicity ntawm 长链正alkylcarboxylate, ntsuas los ntawm lawv qhov kev faib tawm ntawm hydrogen peroxide thiab aqueous kua.Smith, R. thiab Tanford, K. Hydrophobicity ntawm cov saw ntev n-alkylcarboxylic acids ntsuas los ntawm lawv qhov kev faib tawm ntawm heptane thiab aqueous daws.txheej txheem. National Academy of Sciences. science US 70, 289 (1973).
Liu, J. et al. Ib zaug ib lub lim tiam nrhiav pom ntawm semaglutide analog ntawm glucagon-zoo li peptide-1 (GLP-1). J. Tshuaj. Tshuaj. 58, 7370–7380 (2015). Qhov kev ua haujlwm no ua rau pom thawj zaug ntawm kev siv ib zaug ib lub lim tiam fatty acid derivatization txoj kev.
Østergaard, S. et al. Cov nyhuv ntawm tib neeg PYY3-36 dibasic fatty acid acylation ntawm mini-pig Y2 receptor kev ua si thiab ib nrab-lub neej. kev kawm. Qhia 11, 21179 (2021). Tsab ntawv xov xwm no qhia txog qhov tseem ceeb ntawm fatty acid txoj hauj lwm, linker thiab caj qaum stability nyob rau hauv txoj kev loj hlob ntawm ib nrab-lub neej PYY analogs.
Ensenat-Vaser, R. et al. Kev nkag mus ntawm myristoylated peptides thoob plaws lub cell membrane tau ncaj qha pom siv confocal fluorescence microscopy. IUBMB Life 54, 33–36 (2002).
Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl-raws li thauj peptides mus rau hauv cov hlwb muaj sia. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl-raws li thauj peptides mus rau hauv cov hlwb muaj sia.Nelson AR, Borland L, Allbritton NL. thiab Sims SE Peptide thauj hauv cov hlwb nyob yog ua raws li myristoyl. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE 基于肉豆蔻酰的肽转运到活细胞中. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE.Nelson, AR, Borland, L., Albritton, NL. thiab Sims, KE Thauj ntawm myristoyl-raws li peptides rau hauv cov hlwb nyob.Biochemistry 46, 14771–14781 (2007).
Kabanov, AV, Levashov, AV & Alakhov, VY Lipid hloov kho cov proteins thiab lawv cov membrane thauj. Kabanov, AV, Levashov, AV & Alakhov, VY Lipid hloov kho cov proteins thiab lawv cov membrane thauj.Kabanov AV, Levashov AV, Alakhov V.Yu. Lipid hloov pauv ntawm cov protein thiab lawv cov membrane thauj. Kabanov, AV, Levashov, AV & Alakhov, VY 蛋白质的脂质修饰及其膜转运. Kabanov, AV, Levashov, AV & Alakhov, VYKabanov AV, Levashov AV, Alakhov, Lipid hloov kho ntawm VY proteins thiab lawv cov membrane thauj.protein engineering. Dec. Searl. 3, 39–42 (1989).
Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation txhim kho cov cellular internalization thiab cytosolic tis ntawm cystine-knot peptide. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Fatty acylation txhim kho cov cellular internalization thiab cytosolic tis ntawm cystine-knot peptide.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. thiab Hannoosh, RN Fatty acid acylation txhim kho cellular internalization thiab cytosolic faib ntawm peptide nrog lub voj cystine. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN 脂肪酰化增强了胱氨酸结肽的细胞内化和胞质分布. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. thiab Hannoosh, RN Fatty acylation txhim kho cellular internalization thiab cytoplasmic faib ntawm cystine peptides.iScience 24, 103220 (2021).
Baker, EM et al. Ib nrab-lub neej-ntev kev hloov kho ntawm YY3-36 peptide rau kev ncaj qha receptor-mediated internalization. Moore. tshuaj kho mob. 16, 3665–3677 (2019).
Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Txoj hauj lwm thiab qhov ntev ntawm cov roj ntsha muaj zog cuam tshuam rau receptor selectivity qauv ntawm tib neeg pancreatic polypeptide analogues. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Txoj hauj lwm thiab qhov ntev ntawm cov roj ntsha muaj zog cuam tshuam rau receptor selectivity qauv ntawm tib neeg pancreatic polypeptide analogues.Made, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. thiab Beck-Sickinger, AG Txoj hauj lwm thiab qhov ntev ntawm fatty acids muaj zog cuam tshuam rau cov qauv xaiv ntawm tib neeg pancreatic polypeptide analog receptors. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil​er, J. & Beck-Sickinger, AG脂肪酸的位置和长度强烈影响人胰腺多肽类似物的受体选择性模式. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil​er, J. & Beck-Sickinger, AGMade, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. thiab Beck-Sickinger, AG Txoj hauj lwm thiab qhov ntev ntawm fatty acids muaj zog cuam tshuam rau cov qauv xaiv ntawm tib neeg pancreatic analog polypeptide receptors.HimMedChem 9, 2463–2474 (2014).
Aleksopoulou, F. et al. Lub lipid metabolite PrRP31 yog qhov ua haujlwm ntev dual GPR10 thiab NPFF2 receptor agonist nrog lub zog poob qhov hnyav. kev kawm. Qhia 12, 1696 (2022). Txoj kev tshawb no qhia txog qhov sib txawv ntawm mono- thiab diacid side chains.
Poulsen, K. et al. Txoj kev loj hlob ntawm kev ruaj khov agonists ntawm Y2 receptor peptide PYY3-36. tshuaj kho mob. cia tank. 38, 1369–1385 (2021).
Conde-Frieboes, K. et al. Kev txheeb xyuas thiab tus cwj pwm ntawm hauv vitro thiab hauv vivo analogues ntawm kev ua haujlwm ntev thiab xaiv melanocortin 4 receptor (MC4-R) alpha-melanocyte-stimulating hormone (alpha-MSH). J. Tshuaj. Tshuaj. 55, 1969–1977 (2012).
Ramirez-Andersen, HS et al. Ntev-ua tib neeg txoj kev loj hlob hormone analogues khi rau cov tsis-covalent albumin. Bioconjugate. Tshuaj. 29, 3129–3143 (2018).
Madsen, K. et al. Structure-activity kev sib raug zoo thiab elongation ntawm ntev-acting glucagon-zoo li peptide-1 derivatives: qhov tseem ceeb ntawm fatty acid ntev, polarity, thiab ntim. J. Tshuaj. Tshuaj. 50, 6126–6132 (2007).
Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Ob-acylated GLP-1 derivatives. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Ob-acylated GLP-1 derivatives. Wieczorek, B., Spetsler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Дважды ацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Doubly acylated derivatives ntawm GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Диацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Diacylated derivatives ntawm GLP-1.US Patent WO2012/140117 (2012).
Young, P.-Yu. Tos. Muaj peev xwm, ua haujlwm ntev GLP-1 analogs tsim rau kev xa khoom xa mus raws li microstructure. txheej txheem. National Academy ntawm Science. kev kawm. US 113, 4140–4145 (2016).
Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Kev Tshawb Fawb txog kev nyab xeeb, kev ua siab ntev, pharmacokinetics, thiab cov tshuaj pharmacodynamics ntawm ib zaug thiab ntau koob ntawm kev ua yeeb yam ntev α-MSH analog hauv kev noj qab haus huv thiab rog. yam. Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Kev Tshawb Fawb txog kev nyab xeeb, kev ua siab ntev, pharmacokinetics, thiab cov tshuaj pharmacodynamics ntawm ib zaug thiab ntau koob ntawm kev ua yeeb yam ntev α-MSH analog hauv kev noj qab haus huv thiab rog. yam.Royalty, JE, Konradsen, G., Eskerod, O., Hma, BS thiab Hansen, BS Safety, tolerability, pharmacokinetics, thiab pharmacodynamics kawm ntawm ib zaug thiab ntau koob tshuaj ntawm kev ua yeeb yam ntev α-MSG analog hauv kev noj qab haus huv rog thiab rog.版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS 单剂量和多剂量长效α-MSH类似物在健康超重和肥胖患者中的安全性、耐受性、药代动力学和药效学研究瑼。版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Ib zaug noj thiab ntau npaum li cas ntev α-MSH全健康超重和肥胖可以中可以可以而受性、药代报学和药效学研究科目.Royalty, JE, Konradsen, G., Eskerod, O., Hma, BS thiab Hansen, BS Safety, tolerability, pharmacokinetics ntawm ib leeg thiab ntau koob tshuaj ntev-acting alpha-MSG analogues hauv kev noj qab haus huv rog thiab rog. Kinetics thiab pharmacodynamics.J. Clin. Pharmacodynamics. 54, 394–404 (2014).
Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues.Lau, J., F., Kruse, T., Linderoth, L. and Togersen, H. New glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. 新型胰高血糖素类似物. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H.Lau, J., F., Cruz, T., Linderoth, L. and Togersen, H. New glucagon analogues.US Patent WO2011/117416 A1 (2011).
Ward, BP et al. Lipidation ntawm peptides stabilizes cov qauv los txhim kho kev ua haujlwm lom neeg. Moore. metabolism. 2, 468–479 (2013). Txoj haujlwm no qhia txog lub luag haujlwm ntawm fatty acid side chains hauv kev txiav txim siab cov qauv kev ruaj ntseg thiab kev khi ntawm peptide tshuaj receptors.
Koskun T. et al. LY3298176, ib qho tshiab dual GIP thiab GLP-1 receptor agonist rau kev kho mob ntshav qab zib hom 2: los ntawm kev tshawb pom mus rau cov ntaub ntawv pov thawj ntawm lub tswv yim. Moore. metabolism. 18, 3-14 (2018). Daim ntawv no nthuav tawm cov qauv tsim ntawm thawj fatty acid-derived GLP-1 / GIP co-agonist rau kev tswj hwm ib lub lim tiam hauv tsev kho mob.
Kjeldsen, TB et al. Molecular engineering ntawm icodec insulin, thawj zaug ib lub lim tiam acylated insulin analog hauv tib neeg. J. Tshuaj. Tshuaj. 64, 8942–8950 (2021). Daim ntawv no nthuav tawm thawj txoj kev loj hlob ntawm fatty acid derived insulin rau ib zaug ib lub lim tiam.
van Witteloostein, SB et al. Neoglycolipids rau kev ua haujlwm ntev peptides: nws tus kheej sib dhos analogs ntawm glucagon-zoo li peptide 1 nrog albumin-binding zog thiab siab hauv vivo potency. Moore. tshuaj kho mob. 14, 193–205 (2017).
Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide khi albumin nrog siab affinity thiab daim ntawv thov raws li tag furnishes ntev-acting peptides. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide khi albumin nrog siab affinity thiab daim ntawv thov raws li tag furnishes ntev-acting peptides.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. thiab Haynes, S. Acylated heptapeptide khi albumin nrog siab affinity, thiab nws siv raws li ib daim ntawv lo muab ib tug ntev-acting peptide. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 酰化七肽以高亲和力结合白蛋白 Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Cov tshuaj peptide yog siv los ua cov tshuaj peptide.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. thiab Haynes, S. Acylated heptapeptides khi albumin nrog siab affinity thiab ua cov ntawv rau kev xa mus ntev peptide.Nat. sib txuas lus 8, 16092 (2017).