Khoom siv: Linaclotide
Lub npe: Linaclotide Acetate
CAS Nr .: 851199-59-2
Cov roj formula: C59H79N15O21S6
Molecular Luj: 1526.8
Qhov tsos: Dawb hmoov
Purity:> 98%
Tom ntej: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH

Linaclotide yog ib tug hluavtaws, kaum plaub amino acid peptide thiab agonist ntawm plab hnyuv guanylate cyclase hom C (GC-C), uas yog structurally cuam tshuam rau guanylin peptide tsev neeg, nrog secretagogue, analgesic thiab laxative kev ua ub no. Raws li kev tswj hwm qhov ncauj, linaclotide khi rau thiab ua kom muaj GC-C receptors nyob rau ntawm qhov chaw luminal ntawm txoj hnyuv epithelium. Qhov no ua rau kom cov concentration ntawm intracellular cyclic guanosine monophosphate (cGMP), uas yog muab los ntawm guanosine triphosphate (GTP). cGMP activates cystic fibrosis transmembrane conductance regulator (CFTR) thiab txhawb nqa cov chloride thiab bicarbonate rau hauv cov hnyuv lumen. Qhov no txhawb nqa sodium excretion mus rau hauv lub lumen thiab ua rau muaj zog plab hnyuv secretion. Qhov no thaum kawg ua kom GI hloov ntawm txoj hnyuv, txhim kho plab hnyuv thiab txo qhov cem quav. Kev nce ntxiv ntawm cov cellular cGMP kuj tseem tuaj yeem ua rau cov nyhuv antinociceptive, los ntawm ib qho tseem tsis tau elucidated mechanism, uas tej zaum yuav muaj kev hloov kho ntawm nociceptors pom nyob rau hauv colonic afferent mob fibers. Linaclotide yog absorbed tsawg kawg nkaus los ntawm GI ib ntsuj av.