Khoom: LinagLotide
Synonym: linaclotide acetate
CAS Tsis muaj: 851199-59-2
Molecular Cov Qauv: C59H79N15o21S6
Molecular hnyav: 1526.8
Zog: Cov hmoov dawb dawb
Purity:> 98%
Sequence: Nh2-Cys-Cys-Tyr-Tyr-cys-cys-cys-cys-cys-cys-cys-cys-a-ala-cys-cys-cys-tyr-h

Linaclotide yog cov khoom siv hluavtaws, kaum plaub amino acid peptide thiab agonist ntawm guanany cyclas, nrog zais pa, nrog zais pa thiab laxative ua si. Thaum lub sij hawm tswj, linacleide khi rau thiab ua kom ua kom GC-C tau txais nyob rau ntawm lub plab hnyuv epithelium. Qhov no nce cov concentration ntawm intracellular cancain guanosphaate (CGMP), uas yog muab tau los ntawm Guanosine Triphosphate (GTP). CGMP accordates cystic fibrosis transmembrane kev tswj hwm (CFTR) thiab ua rau cov pa luam yeeb thiab bicarbonate rau hauv plab hnyuv. Qhov no txhawb nqa sodium excretion mus rau hauv lub lumen thiab cov txiaj ntsig tau nce cov roj plab zom mov. Qhov no thaum kawg ua kom nrawm GI transit ntawm cov hnyuv sab nrauv, txhim kho cov plab hnyuv txav thiab cov quav tawv quav. Cov qib tshuaj ntxiv kuj tseem yuav ua rau muaj cov nyhuv antinociceptive, dhau los ntawm cov nociceptors pom ntawm colonic afferent mob cov hmoov. LinacLotide yog qhov tsawg heev nqus tau ntawm GI li.