1ml: 4μg / 1ml: 15μg Lub Zog

Kev taw qhia:

Kev qhia thiab kev siv

Hemophilia A: Desmopress nyob rau hauv Acetate Txhaj 4 mcg / mL yog qhia rau cov neeg mob hemophilia A nrog qhov ua tau VIII coagulant ntau dua 5%.

Desmopress hauv kev txhaj tshuaj acetate feem ntau yuav tswj cov hemostasis hauv cov neeg mob hemophilia A thaum lub sijhawm phais thiab tom qab phais thaum noj 30 feeb ua ntej cov txheej txheem teem tseg.

Desmopress hauv kev txhaj tshuaj acetate kuj tseem yuav tso tseg los ntshav hauv hemophilia A cov neeg mob uas muaj qhov tshwm sim ntawm qhov tshwm sim los yog raug mob tshwm sim xws li hemarthroses, intramuscular hematomas lossis los ntshav mucosal.

Desmopress hauv kev txhaj tshuaj acetate tsis tau qhia rau kev kho mob hemophilia A nrog qhov ua haujlwm VIII coagulant qib sib npaug lossis tsawg dua 5%, lossis rau kev kho mob hemophilia B, lossis hauv cov neeg mob uas muaj cov tshuaj tiv thaiv VIII.

Hauv qee qhov xwm txheej kho mob, nws tuaj yeem tsim nyog sim desmopress hauv kev txhaj tshuaj acetate hauv cov neeg mob uas muaj qib VIII ntawm 2% mus rau 5%; Txawm li cas los xij, cov neeg mob no yuav tsum tau ua tib zoo saib xyuas. von Willebrand's Disease (Hom I): Desmopres s hauv kev txhaj tshuaj acetate 4 mcg / mL yog qhia rau cov neeg mob uas muaj mob me mus rau nruab nrab classic von Willebrand tus kab mob (Hom I) nrog qib VIII ntau dua 5%. Desmopress hauv kev txhaj tshuaj acetate feem ntau yuav tswj hwm hemostasis hauv cov neeg mob uas mob me mus rau nruab nrab von Willebrand tus kab mob thaum lub sij hawm phais thiab tom qab phais thaum noj 30 feeb ua ntej cov txheej txheem teem tseg.

Desmopress nyob rau hauv kev txhaj tshuaj acetate feem ntau yuav tso tseg los ntshav me me mus rau nruab nrab von Willebrand cov neeg mob nrog lub sijhawm ntawm kev raug mob los yog raug mob xws li hemarthroses, intramuscular hematomas los yog mucosal los ntshav.

Cov neeg mob von Willebrand tus kab mob uas tsawg kawg yuav teb tau yog cov neeg mob hnyav homozygous von Willebrand tus kab mob nrog qhov ua haujlwm VIII coagulant thiab yam VIII von

Willebrand yam antigen qib qis dua 1%. Lwm tus neeg mob tuaj yeem teb rau hauv ib qho kev sib txawv nyob ntawm seb hom molecular defect lawv muaj. Lub sij hawm los ntshav thiab qhov tseem ceeb VIII coagulant kev ua si, ristocetin cofactor kev ua, thiab von Willebrand yam antigen yuav tsum tau kuaj xyuas thaum lub sij hawm tswj hwm ntawm desmopress hauv acetate txhaj tshuaj kom paub meej tias cov qib txaus tau ua tiav.

Desmopress hauv kev txhaj tshuaj acetate tsis tau qhia rau kev kho mob hnyav classic von Willebrand tus kab mob (Hom I) thiab thaum muaj pov thawj ntawm qhov txawv txav ntawm daim ntawv molecular ntawm yam VIII antigen.

Ntshav Qab Zib Insipidus: Desmopress hauv kev txhaj tshuaj acetate 4 mcg / mL yog qhia raws li kev kho cov tshuaj tiv thaiv diuretic hloov hauv kev tswj hwm hauv nruab nrab (cranial) ntshav qab zib insipidus thiab rau kev tswj hwm ntawm ib ntus polyuria thiab polydipsia tom qab lub taub hau raug mob lossis phais hauv thaj tsam pituitary.

Desmopress hauv kev txhaj tshuaj acetate tsis zoo rau kev kho mob ntshav qab zib nephrogenic insipidus.

Desmopress nyob rau hauv acetate kuj muaj raws li kev npaj intranasal. Txawm li cas los xij, qhov kev xa tawm no tuaj yeem cuam tshuam los ntawm ntau yam uas tuaj yeem ua rau qhov ntswg insufflation tsis zoo lossis tsis tsim nyog.

Cov no muaj xws li intranasal absorption tsis zoo, qhov ntswg congestion thiab blockage, qhov ntswg tawm, atrophy ntawm qhov ntswg mucosa, thiab mob atrophic rhinitis. Intranasal xa tuaj yuav tsis tsim nyog thaum muaj kev tsis nco qab. Tsis tas li ntawd, cov txheej txheem phais mob cranial, xws li transsphenoidal hypophysectomy, tsim cov xwm txheej uas yuav tsum muaj lwm txoj hauv kev ntawm kev tswj hwm xws li hauv qhov ntswg pob lossis rov qab los ntawm kev phais.

CONTRAINDICATIONS

Desmopress nyob rau hauv acetate txhaj 4 mcg / mL yog contraindicated nyob rau hauv cov neeg uas paub hypersensitivity rau desmopress nyob rau hauv acetate los yog rau ib yam ntawm cov Cheebtsam ntawm desmopress nyob rau hauv acetate txhaj 4 mcg / mL.

Desmopress hauv kev txhaj tshuaj acetate yog contraindicated nyob rau hauv cov neeg mob uas muaj mob raum mus rau mob hnyav (txhais tias yog creatinine tshem tawm hauv qab 50 ml / min).

Desmopress nyob rau hauv acetate txhaj yog contraindicated nyob rau hauv cov neeg mob nrog hyponatremia los yog keeb kwm ntawm hyponatremia.