Huahana: Linaclotide
Synonym: Linaclotide Acetate
Helu CAS: 851199-59-2
Ke Kumu Molekala: C59H79N15O21S6
Kaumaha Molekala: 1526.8
Ke ʻano: ʻO ka pauka keʻokeʻo
Maʻemaʻe: >98%
Sequence: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH

ʻO Linaclotide kahi synthetic, ʻumikūmāhā amino acid peptide a me ka agonist o ka intestinal guanylate cyclase type C (GC-C), i pili i ka ʻohana guanylin peptide, me nā hana huna, analgesic a me nā hana laxative. Ma ka hoʻoponopono waha, hoʻopaʻa ʻia ka linaclotide a hoʻāla i nā mea loaʻa GC-C aia ma ka ʻaoʻao luminal o ka epithelium intestinal. Hoʻonui kēia i ka manaʻo o intracellular cyclic guanosine monophosphate (cGMP), i loaʻa mai ka guanosine triphosphate (GTP). Hoʻoulu ka cGMP i ka cystic fibrosis transmembrane conductance regulator (CFTR) a hoʻoulu i ka huna ʻana o ka chloride a me ka bicarbonate i loko o ka lumen ʻōpū. Hoʻoikaika kēia i ka hoʻokuʻu ʻana o ka sodium i loko o ka lumen a me ka hopena i ka hoʻonui ʻana i ka wai o ka ʻōpū. ʻO kēia ka mea e hoʻolalelale ai i ka GI transit o ka ʻōpū, hoʻomaikaʻi i ka neʻe ʻana o ka ʻōpū a hoʻomaha i ka constipation. Hiki ke hoʻonui ʻia nā pae cGMP extracellular i kahi hopena antinociceptive, ma o kahi ʻano hana i wehewehe ʻole ʻia, hiki ke komo i ka modulation o nā nociceptors i loaʻa ma ka colonic afferent pain fibers. Hoʻopili liʻiliʻi ʻia ʻo Linaclotide mai ka ʻāpana GI.