Na gode da ziyartar Nature.com. Sigar burauzar da kuke amfani da ita tana da iyakacin tallafin CSS. Don ƙwarewa mafi kyau, muna ba da shawarar ku yi amfani da sabuntar burauza (ko kuma musaki Yanayin dacewa a cikin Internet Explorer). A halin yanzu, don tabbatar da ci gaba da goyan baya, za mu sanya rukunin yanar gizon ba tare da salo da JavaScript ba.
Ana amfani da peptides da sunadaran don magance cututtuka iri-iri, amma yawanci sai an yi musu allura kuma tasirinsu yana da ɗan gajeren lokaci. Ana iya kawar da waɗannan gazawar na tsarin asali tare da taimakon injiniyan kwayoyin halitta, amma wannan aiki ne mai wuyar gaske. Dabarun injiniyan kwayoyin halitta, waɗanda aka fara amfani da su ga insulin kuma a yanzu an yi nasarar amfani da su ga magungunan biopharmaceutical da yawa, suna buƙatar cire peptides da sunadarai daga fatty acids. Ƙayyadaddun halaye da wuri na fatty acid ɗin da aka haɗe na iya samar da hanyoyin haɓaka daban-daban. Bugu da ƙari, wannan fasaha na iya samar da tsawon rabin rayuwa bayan gudanarwa ta baki na magungunan peptide, na iya canza rarraba peptides, kuma yana iya samun damar yin niyya na nama. Tare da ingantaccen aminci na fatty acid da ingantattun kaddarorin sinadarai, wannan fasaha tana ba da wata hanya mai mahimmanci don gano magungunan peptide da furotin.
Duk farashin su ne. Za a ƙara VAT daga baya a wurin biya. Za a yi lissafin haraji a wurin biya.
Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Trends a cikin gano magungunan peptide. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF Trends a cikin gano magungunan peptide.Muttenthaler, M., King, GF, Adams, DJ da Alevud, PF Trends a cikin gano magungunan peptide. Muttenthaler, M., King, GF, Adams, DJ & Alewood, PF 多肽药物发现的趋势。 Muttenthaler, M., King, GF, Adams, DJ & Alewood, PFMuttenthaler, M., King, GF, Adams, DJ da Alevud, PF Trends a cikin gano magungunan peptide.Kasa Bude Faston Magunguna. 20, 309-325 (2021). Wannan bita yana mai da hankali kan abubuwan da ke faruwa na yanzu da na gaba na gano magungunan peptide.
Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-kiba gano magungunan: ci gaba da kalubale. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD Anti-kiba gano magungunan: ci gaba da kalubale.Müller, TD, Blucher, M., Chop, MH da DiMarchi, RD Anti-kiba gano magunguna: ci gaba da kalubale. Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RD 抗肥胖药物发现：进展和挑战。 Müller, TD, Blüher, M., Tschöp, MH & DiMarchi, RDMüller, TD, Blucher, M., Chop, MH da DiMarchi, RD Anti-kiba gano magunguna: ci gaba da kalubale.Kasa Bude Faston Magunguna. 21, 201-223 (2022). Wannan bita yana ba da haske game da matsalolin kiba, musamman sabbin dabaru dangane da peptides.
Strohl, WR Fusion sunadaran don tsawaita rabin rayuwar ilimin halittu a matsayin mafi kyawun dabarun ilimin halitta. Biopharmaceutics 29, 215-239 (2015).
Evans, M. et al. Rikowa da dagewa na magungunan ciwon sukari da haɗin gwiwa tare da sakamakon asibiti da tattalin arziki a cikin marasa lafiya da nau'in ciwon sukari na 2: nazari na yau da kullum na wallafe-wallafe. ciwon sukari kiba. metabolism. 24, 377-390 (2022).
Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Ra'ayoyin marasa lafiya akan magunguna na mako-mako sau ɗaya don ciwon sukari. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH Ra'ayoyin marasa lafiya akan magunguna na mako-mako sau ɗaya don ciwon sukari.Polonsky WH, Fisher L., Hessler D., Brune D., da Mafi kyawun hangen nesa na JH A kan magungunan ciwon sukari sau ɗaya-mako. Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JH 患者对每周一次的糖尿病药物的看法。 Polonsky, WH, Fisher, L., Hessler, D., Bruhn, D. & Best, JHPolonsky WH, Fisher L., Hessler D., Brune D., da Mafi kyawun fahimtar marasa lafiya na JH na magungunan ciwon sukari sau ɗaya-mako.ciwon sukari kiba. metabolism. 13, 144-149 (2011).
Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis na palmitoyl abubuwan da aka samo na insulin da ayyukansu na halitta. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis na palmitoyl abubuwan da aka samo na insulin da ayyukansu na halitta.Hashimoto M., Takada K., Kiso Y. da Muranishi S. Haɗin gwiwar abubuwan palmitoyl na insulin da ayyukansu na rayuwa. Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. 胰岛素棕榈酰衍生物的合成及其生物活性。 Hashimoto, M., Takada, K., Kiso, Y. & Muranishi, S. Synthesis da ayyukan nazarin halittu na abubuwan haɓakar insulin palmitoyl.Hashimoto M., Takada K., Kiso Y. da Muranishi S. Haɗin kai da ayyukan nazarin halittu na abubuwan haɓakar insulin palmitoyl.Tafkin magani 6, 171-176 (1989).
Kurthals, P. et al. Albumin daure zuwa insulin-acylated fatty acid: halayyar hulɗar ligand-protein da alaƙa tsakanin haɗin kai da lokacin aikin insulin a cikin vivo. biochem. J. 312, 725-731 (1995). Wannan aikin shine farkon wanda ya nuna karuwa a cikin rabin rayuwa saboda daurin albumin zuwa peptides da aka samu daga fatty acids.
Mejuch, T. & Waldmann, H. Haɗin sunadaran lipidated. Mejuch, T. & Waldmann, H. Haɗin sunadaran lipidated.Meyukh, T. da Waldmann, H. Haɗin sunadaran lipidated. Mejuch, T. & Waldmann, H. 脂化蛋白质的合成。 Mejuch, T. & Waldmann, H.Meyukh, T. da Waldmann, H. Haɗin sunadaran lipidated.Bioconjugate. Chemical 27, 1771-1783 (2016).
Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation a cikin siginar salula da cututtuka: aiki, tsari, da damar warkewa. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein lipidation a cikin siginar salula da cututtuka: aiki, tsari, da damar warkewa.Chen B., Sun Y., Niu J., Jarugumilli GK da Wu X. Protein lipidation a cikin siginar salula da cututtuka: aiki, tsari, da yiwuwar warkewa. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Chen, B., Sun, Y., Niu, J., Jarugumilli, GK & Wu, X. Protein 脂化 a cikin siginar salula da cututtuka: aiki, tsari da damar warkewa.Chen B., Sun Y., Niu J., Jarugumilli GK da Wu X. Protein lipidation a cikin siginar salula da cututtuka: aiki, tsari, da yiwuwar warkewa.cytochemistry. ilmin halitta 25, 817-831 (2018).
Richter, WF, Bhansali, SG & Morris, ME Mechanistic masu ƙayyade sha biotherapeutics biyo bayan gudanar da SC. Richter, WF, Bhansali, SG & Morris, ME Mechanistic masu ƙayyade sha biotherapeutics biyo bayan gudanar da SC.Richter, VF, Bhansali, SG da Morris, ME Mechanisms waɗanda ke ƙayyade sha na magungunan biotherapeutic bayan gudanarwar subcutaneous. Richter, WF, Bhansali, SG & Morris, ME SC 给药后生物治疗药物吸收的机制决定因素。 Richter, WF, Bhansali, SG & Morris, ME SC Richter, WF, Bhansali, SG & Morris, ME SC Механистические детерминанты. Richter, WF, Bhansali, SG & Morris, ME SC Mechanistic ma'anar ɗaukar magungunan biotherapeutic bayan gudanarwa.AAPS J. 14, 559-570 (2012).
Gradel, AKJ et al. Abubuwan da ke shafar shayarwar insulin subcutaneous: abubuwan da ke haifar da canji. J. Ciwon sukari Res. 2018, 1205121 (2018).
Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion da polymerization yana ƙayyade ƙwayar insulin daga ƙwayar ƙwayar cuta a cikin masu ciwon sukari. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion da polymerization yana ƙayyade ƙwayar insulin daga ƙwayar ƙwayar cuta a cikin masu ciwon sukari. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Диффузия и полимеризация пациентов с диабетом. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Diffusion da polymerization sun ƙayyade shayarwar insulin daga ƙwayar ƙwayar cuta a cikin masu ciwon sukari. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Диффузия и агрегация. пациентов с диабетом. Hildebrandt, P., Sejrsen, P., Nielsen, SL, Birch, K. & Sestoft, L. Yaduwa da tarawa suna ƙayyade sha insulin subcutaneous a cikin masu ciwon sukari.dubawa. J. Klin. dakin gwaje-gwaje. zuba jari. 45, 685-690 (1985).
Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modeling sha motsi na subcutaneous allura mai narkewa insulin. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. Modeling sha motsi na subcutaneous allura mai narkewa insulin.Mosekilde E, Jensen KS, Binder S, Pramming S, da Thorsteinsson B. Samfuran tsarin sha na insulin mai narkewa mai narkewa. Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B. 模拟皮下注射可溶性胰岛素的吸收动力学。 Mosekilde, E., Jensen, KS, Binder, C., Pramming, S. & Thorsteinsson, B.Mosekilde E, Jensen KS, Binder S, Pramming S, da Thorsteinsson B. Samfuran tsarin sha na insulin mai narkewa da ake gudanarwa ta subcutaneously.J. Pharmacokinetics. maganin rigakafi. 17, 67-87 (1989).
Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Girman kwayoyin halitta yana daidaita magunguna, rarraba kwayoyin halitta, da ajiyar koda na isar da magungunan bioopolymer elastin-kamar polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Girman kwayoyin halitta yana daidaita magunguna, rarraba kwayoyin halitta, da ajiyar koda na isar da magungunan bioopolymer elastin-kamar polypeptide. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Размер молекулы Biopolimernogo эlastynopodobnogo polippeptida da sredstva. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Girman kwayoyin halitta yana daidaita magungunan magunguna, rarrabawar halittu, da ajiyar koda na biopolymeric elastin-kamar polypeptide don isar da magani. Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III分子大小调节药物递送生物聚合物弹性蛋白样多肽的药代动力学态生物聚合物弹 Kuna, M., Mahdi, F., Chade, AR & Bidwell, GL III Molecule 大小名行电影送送biological polymer elastic protein sample 多如乐的药代报学学, nazarin halittuKuna, M., Mahdi, F., Chad, AR dan Bidwell, GL III. Pharmacokinetics, biodistribution da renal jijiya na biopolymeric elastin-kamar polypeptides daidaita girman kwayoyin.Rahoton kimiyya 8, 7923 (2018).
Harris, JM, Martin, NE & Modi, M. Pegylation: wani sabon tsari don gyara magunguna. Harris, JM, Martin, NE & Modi, M. Pegylation: wani sabon tsari don gyara magunguna. Harris, JM, Martin, NE & Modi, M. Пегилирование. Harris, JM, Martin, NE & Modi, M. Pegylation: wani sabon tsari don gyara magunguna. Harris, JM, Martin, NE & Modi, M. 聚乙二醇化：一种改变药代动力学的新方法。 Harris, JM, Martin, NE & Modi, M. 聚乙二感化: sabuwar hanyar canza magani. Harris, JM, Martin, NE & Modi, M. Пегилирование: Harris, JM, Martin, NE & Modi, M. Pegylation: sabuwar hanyar canza magunguna.na asibiti. Pharmacokinetics. 40, 539-551 (2001).
Elmerer, M. et al. Ma'auni na tsaka-tsakin albumin a cikin tsokar kwarangwal na ɗan adam da adipose tissue ta hanyar buɗewar microperfusion. Ee. J. Physiology. endocrine. metabolism. 278, E352-E356 (2000).
Nelson, J. et al. Tsawon rabin rayuwar albumin a cikin mutane yana buƙatar cikakken C-terminus. sadarwa. ilmin halitta. 3, 181 (2020).
Chowdhury, K. et al. Mai karɓar Fc (FcRn) na IgG wanda ke da alaƙa da babban hadaddun daidaitawar tarihin yana ɗaure albumin kuma yana tsawaita rayuwarsa. J. Exp. magani. 197, 315-322 (2003).
Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis na IgG kamar yadda mai karɓa ya shiga tsakani, FcRn: nazari a matakin kwayar halitta guda ɗaya. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Exocytosis na IgG kamar yadda mai karɓa ya shiga tsakani, FcRn: nazari a matakin kwayar halitta guda ɗaya. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Эkzotsitoz IgG, oposredovannыy rеtseptorom FcRn: анализ на уровне однумы. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES FcRn mai karɓar mai karɓa na IgG exocytosis: nazarin kwayoyin halitta guda ɗaya. Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES 受体介导的IgG 胞吐作用，FcRn：单分子水平的分析。 Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, Эkzotsytoz IgG, oposredovannыy respeptorom ES, FcRn: analiz на уровне одныy Ober, RJ, Martinez, C., Lai, X., Zhou, J. & Ward, ES mai karɓar mai karɓa na IgG exocytosis, FcRn: nazarin matakin-matakin ƙwayoyin cuta guda ɗaya.tsari. Kwalejin Kimiyya ta Kasa. ilimin kimiyya. Amurka 101, 11076 (2004).
Shi, XM & Carter, Tsarin Atomic na DC da sinadarai na albumin ɗan adam. Shi, XM & Carter, Tsarin Atomic na DC da sinadarai na albumin ɗan adam.Kunna, XM da Carter, DC Tsarin Atomic da sinadarai na albumin ɗan adam. He, XM & Carter, DC 人血清白蛋白的原子结构和化学。 Shi, XM & Carter, DC.Kunna, XM da Carter, DC Tsarin Atomic da sinadarai na albumin ɗan adam.Yanayin 358, 209-215 (1992).
Curry, S., Mandelkow, H., Brick, P. & Franks, N. Tsarin kristal na jini na albumin na ɗan adam wanda aka haɗa tare da fatty acid yana bayyana rabe-raben asymmetric na wuraren dauri. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Tsarin kristal na jini na albumin na ɗan adam wanda aka haɗa tare da fatty acid yana bayyana rabe-raben asymmetric na wuraren dauri.Curry S., Mandelkow H., Brick P. da Franks N. Tsarin lu'ulu'u na jini na albumin na ɗan adam a cikin hadaddun tare da fatty acid yana nuna daidaitaccen rarraba wuraren dauri. Curry, S., bulo, P. & Franks, N. 的 的 的 的 的 不对称分布 的 不对称分布 的 的 的 不对称分布. Curry, S., Mandelkow, H., Brick, P. & Franks, N. Tsarin lu'ulu'u na hadaddun furotin na jini na jini tare da fatty acids yana bayyana rarrabawar wuraren dauri na asymmetric.Curry S., Mandelkow H., Brick P. da Franks N. Tsarin lu'ulu'u na jini na albumin na ɗan adam a cikin hadaddun tare da fatty acids yana nuna rarrabuwar asymmetric na wuraren dauri.Nat. tsari. ilmin halitta 5, 827-835 (1998). Wannan takarda tana gabatar da tushen tsarin ɗaure fatty acid zuwa serum albumin.
Irby, D., Du, C. & Li, F. Lipid-maganin magunguna don haɓaka isar da ƙwayoyi. Irby, D., Du, C. & Li, F. Lipid-maganin magunguna don haɓaka isar da ƙwayoyi.Irby, D., Du, K. da Li, F. Lipid-maganin magunguna don ingantaccen isar da magunguna. Irby, D., Du, C. & Li, F. Lipid-drog conjugate don haɓaka isar da magunguna. Irby, D., Du, C. & Li, F. Lipid-drog conjugate don haɓaka isar da magunguna.Irby, D., Du, K. da Li, F. Lipid-drog conjugate don ingantaccen isar da magunguna.Biochemistry 14, 1325-1338 (2017).
Torchilin VP na baya-bayan nan ci gaba a fagen liposomes azaman masu ɗaukar ƙwayoyi. Kasa Bude Faston Magunguna. 4, 145-160 (2005).
Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Dama da ƙalubalen magunguna masu haɗaɗɗun fatty acid. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Dama da ƙalubalen magunguna masu haɗaɗɗun fatty acid.Bhat, M., Jatyan, R., Mittal, A., Mahato, RI da Chitkara, D. Dama da ƙalubalen magunguna masu haɗaɗɗun fatty acid. Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. 脂肪酸共轭疗法的机遇和挑战。 Bhat, M., Jatyan, R., Mittal, A., Mahato, RI & Chitkara, D. Fatty acid 共续电影的机遇和 kalubale.Bhat M., Jatyan R., Mittal A., Mahato RI da Chitkara D. Yiwuwa da ƙalubalen farfagandar fatty acid.Chemical ilimin lissafi Lipids 236, 105053 (2021).
Smith, R. & Tanford, C. Hydrophobicity na dogon sarkar n-alkyl carboxylic acid, kamar yadda aka auna su ta rarraba tsakanin heptane da mafita na ruwa. Smith, R. & Tanford, C. Hydrophobicity na dogon sarkar n-alkyl carboxylic acid, kamar yadda aka auna su ta rarraba tsakanin heptane da mafita na ruwa.Smith, R. da Tanford, K. Hydrophobicity na dogon sarkar n-alkylcarboxylic acid wanda aka auna ta hanyar rarraba su tsakanin heptane da mafita na ruwa. Smith, R. & Tanford, C. 长链正烷基羧酸的疏水性，通过它们在庚烷和水溶液之间的分布来测量。 Smith, R. & Tanford, C. The hydrophobicity na 长链正alkylcarboxylate, auna ta rarraba tsakanin hydrogen peroxide da aqueous bayani.Smith, R. da Tanford, K. Hydrophobicity na dogon sarkar n-alkylcarboxylic acid wanda aka auna ta hanyar rarraba su tsakanin heptane da mafita na ruwa.tsari. Kwalejin Kimiyya ta Kasa. kimiyya US 70, 289 (1973).
Liu, J. et al. Ganowar sati-sati ɗaya na semaglutide analog na glucagon-like peptide-1 (GLP-1). J. Magunguna. Chemical 58, 7370-7380 (2015). Wannan aikin ya nuna a karon farko da yiwuwar amfani da sau ɗaya a mako hanyoyin cire fatty acid.
Østergaard, S. et al. Tasirin ɗan adam PYY3-36 dibasic fatty acid acylation akan ƙaramin alade Y2 mai karɓar aiki da rabin rayuwa. ilimin kimiyya. Rahoton 11, 21179 (2021). Wannan labarin yana nuna mahimmancin matsayi na fatty acid, mai haɗawa da kwanciyar hankali na kashin baya a cikin ci gaba na tsawon rabin rayuwar PYY analogs.
Ensenat-Vaser, R. et al. Shigar da peptides na myristoylated a cikin tantanin halitta an lura da shi kai tsaye ta amfani da microscopy confocal fluorescence. Rayuwar IUBMB 54, 33-36 (2002).
Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl jigilar peptides cikin sel masu rai. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE Myristoyl jigilar peptides cikin sel masu rai.Nelson AR, Borland L, Allbritton NL. da Sims SE jigilar Peptide a cikin sel masu rai sun dogara ne akan myristoyl. Nelson, AR, Borland, L., Allbritton, NL & Sims, CE 基于肉豆蔻酰的肽转到活细胞中。 Nelson, AR, Borland, L., Allbritton, NL & Sims, CE.Nelson, AR, Borland, L., Albritton, NL. da Sims, KE Transport na peptides na tushen myristoyl cikin sel masu rai.Biochemistry 46, 14771-14781 (2007).
Kabanov, AV, Levashov, AV & Alakhov, VY Lipid gyare-gyaren sunadarai da jigilar su. Kabanov, AV, Levashov, AV & Alakhov, VY Lipid gyare-gyaren sunadarai da jigilar su.Kabanov AV, Levashov AV, Alakhov V.Yu. Gyaran lipid na sunadaran da jigilar jikinsu. Kabanov, AV, Levashov, AV & Alakhov, VY 蛋白质的脂质修饰及其膜转运。 Kabanov, AV, Levashov, AV & Alakhov, VYKabanov AV, Levashov AV, Alakhov, Lipid gyare-gyaren sunadaran VY da jigilar su.gina jiki injiniya. Dec. Searl. 3, 39-42 (1989).
Gao, X., Mazière, AD, Gemu, R., Klumperman, J. & Hannoush, RN Fatty acylation yana haɓaka ciki na salula da kuma rarraba cytosolic na peptide cystine-knot. Gao, X., Mazière, AD, Gemu, R., Klumperman, J. & Hannoush, RN Fatty acylation yana haɓaka ciki na salula da kuma rarraba cytosolic na peptide cystine-knot.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. da Hannoosh, RN Fatty acid acylation yana haɓaka ciki na salula da kuma rarraba cytosolic na peptide tare da madauki cystine. Gao, X., Mazière, AD, Beard, R., Klumperman, J. & Hannoush, RN Gao, X., Mazière, AD, Gemu, R., Klumperman, J. & Hannoush, RN.Gao, X., Mazier, AD, Byrd, R., Klumperman, J. da Hannoosh, RN Fatty acylation yana haɓaka ciki na salula da kuma rarraba cytoplasmic na cystine peptides.iScience 24, 103220 (2021).
Baker, EM et al. Gyaran rabin-rayuwa na peptide YY3-36 don shiga tsakani mai karɓa kai tsaye. Moore magani. 16, 3665-3677 (2019).
Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Matsayi da tsayin acid fatty suna tasiri sosai akan tsarin zaɓin mai karɓa na analogues na pancreatic polypeptide ɗan adam. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meiler, J. & Beck-Sickinger, AG Matsayi da tsayin acid fatty suna tasiri sosai akan tsarin zaɓin mai karɓa na analogues na pancreatic polypeptide ɗan adam.Made, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. da Beck-Sickinger, AG Matsayi da tsawon fatty acid suna tasiri sosai akan tsarin zaɓin ɗan adam pancreatic polypeptide analog receptors. Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil'er, J. & Beck-Sickinger, AG脂肪酸的位置和长度强烈影响人胰腺多肽类似物的受体选择性模式。 Mäde, V., Bellmann-Sickert, K., Kaiser, A., Meil'er, J. & Beck-Sickinger, AGMade, W., Bellmann-Sickert, K., Kaiser, A., Mailer, J. da Beck-Sickinger, AG Matsayi da tsayin fatty acid suna tasiri sosai akan tsarin zaɓin ɗan adam pancreatic analog polypeptide receptors.HimMedChem 9, 2463-2474 (2014).
Aleksopoulou, F. et al. Lipid metabolite PrRP31 mai dogon aiki dual GPR10 da NPFF2 agonist mai karɓa tare da tasirin asarar nauyi. ilimin kimiyya. Rahoton 12, 1696 (2022). Wannan binciken dabara yana nuna bambance-bambance tsakanin sarƙoƙin gefen mono- da diacid.
Poulsen, K. et al. Haɓaka ma'ana na barga agonists na Y2 peptide mai karɓa na PYY3-36. magani. tankin ajiya. 38, 1369-1385 (2021).
Conde-Frieboes, K. et al. Ganewa da halayyar in vitro da in vivo analogues na dogon aiki da melanocortin 4 mai karɓa (MC4-R) alpha-melanocyte-stimulating hormone (alpha-MSH). J. Magunguna. Chemical 55, 1969-1977 (2012).
Ramirez-Andersen, HS et al. Analogues na haɓakar ɗan adam mai tsayin aiki wanda ke daure da albumin marasa ƙarfi. Bioconjugate. Chemical 29, 3129-3143 (2018).
Madsen, K. et al. Dangantakar tsarin-ayyukan aiki da haɓakar abubuwan glucagon-kamar peptide-1 masu tsayi: mahimmancin tsayin acid fatty, polarity, da girma. J. Magunguna. Chemical 50, 6126-6132 (2007).
Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Abubuwan GLP-1 sau biyu-acylated. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Abubuwan GLP-1 sau biyu-acylated. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Дважды произванные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Sau biyu acylated na GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. 双酰化GLP-1 衍生物. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Диацилированные производные GLP-1. Wieczorek, B., Spetzler, JC, Kruse, T., Linderoth, L. & Kofoed, J. Diacylated abubuwan da suka samo asali na GLP-1.US Patent WO2012/140117 (2012).
Young, P.-Yu. Jira M, GLP-1 analogs na dogon lokaci wanda aka tsara don isar da transdermal dangane da microstructure. tsari. Kwalejin Kimiyya ta Kasa. ilimin kimiyya. US 113, 4140-4145 (2016).
Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Binciken aminci, haƙuri, pharmacokinetics, da pharmacodynamics na guda ɗaya da mahara allurai na analog na α-MSH mai tsayi a cikin lafiyayyen kiba da kiba. batutuwa. Royalty, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Binciken aminci, haƙuri, pharmacokinetics, da pharmacodynamics na guda ɗaya da mahara allurai na analog na α-MSH mai tsayi a cikin lafiyayyen kiba da kiba. batutuwa.Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS da Hansen, BS Safety, haƙuri, pharmacokinetics, da pharmacodynamics nazarin guda da mahara allurai na dogon-aiki α-MSG analog a cikin lafiya kiba da kiba batutuwa.版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS 单剂量和多剂量长效α-MSH类似物在健康超重和肥胖患者中的安全性、耐受性、药代动力学和药效学稛箛箚箚箚箚箛箚箚箛發。版税, JE, Konradsen, G., Eskerod, O., Wulff, BS & Hansen, BS Single sashi da Multi sashi tsawon sakamako α-MSH全健康超重和肥胖可以中可以可以而受性、药代报学学和药效学研究科箛。Royalty, JE, Konradsen, G., Eskerod, O., Wolf, BS da Hansen, BS Safety, juriya, pharmacokinetics na guda da mahara allurai na dogon-aiki alpha-MSG analogues a cikin lafiya kiba da kiba batutuwa. Kinetics da pharmacodynamics.J. Clin. Pharmacodynamics. 54, 394-404 (2014).
Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. Novel glucagon analogues.Lau, J., F., Kruse, T., Linderoth, L. da Togersen, H. New glucagon analogues. Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H. 新型胰高血糖素类似物。 Lau, J., F., Kruse, T., Linderoth, L. & Thøgersen, H.Lau, J., F., Cruz, T., Linderoth, L. da Togersen, H. New glucagon analogues.US Patent WO2011/117416 A1 (2011).
Ward, BP et al. Lipid na peptides yana daidaita tsarin don haɓaka aikin ilimin halitta. Moore metabolism. 2, 468-479 (2013). Wannan aikin yana nuna rawar sassan sassan fatty acid a cikin ƙayyadaddun tsarin kwanciyar hankali da ɗaure masu karɓar magungunan peptide.
Koskun T. et al. LY3298176, labari mai dual GIP da GLP-1 agonist mai karɓa don maganin nau'in ciwon sukari na 2: daga ganowa zuwa tabbacin asibiti na ra'ayi. Moore metabolism. 18, 3-14 (2018). Wannan takarda tana gabatar da ƙirar farkon fatty acid-wanda aka samu GLP-1/GIP co-agonist don gudanarwa sau ɗaya-mako a asibiti.
Kjeldsen, TB et al. Injiniyan kwayoyin halitta na icodec insulin, analog na insulin acylated na farko-mako-mako a cikin mutane. J. Magunguna. Chemical 64, 8942-8950 (2021). Wannan takarda tana gabatar da farkon haɓakar fatty acid da aka samu insulin na gudanarwa sau ɗaya a mako.
van Witteloostein, SB et al. Neoglycolipids na peptides masu tsayi: haɗin kai analogs na glucagon-kamar peptide 1 tare da kayan ɗaurin albumin kuma yana da ƙarfi a cikin vivo. Moore magani. 14, 193-205 (2017).
Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide yana ɗaure albumin tare da babban kusanci da aikace-aikace kamar yadda alamar ke ba da peptides masu tsayi. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. Acylated heptapeptide yana ɗaure albumin tare da babban kusanci da aikace-aikace kamar yadda alamar ke ba da peptides masu tsayi.Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. da Haynes, S. Acylated heptapeptide yana ɗaure albumin tare da babban alaƙa, kuma amfani dashi azaman lakabi yana samar da peptide mai tsayi mai tsayi. Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 酰化七肽以高亲和力结合白蛋白，并作为栕签提以 Zorzi, A., Middendorp, SJ, Wilbs, J., Deyle, K. & Heinis, C. 鎄化七peptide以高亲和力设计白白约筒，使用设设，使用井设设。Zorzi, A., Middendorp, SJ, Wilbs, J., Dale, K. da Haynes, S. Acylated heptapeptides suna ɗaure albumin tare da babban alaƙa kuma suna aiki azaman lakabi don isar da peptide na dogon lokaci.Nat. sadarwa 8, 16092 (2017).