Linaclotide
Mahimman kalmomi
- LinaclotideTushen
- mafi araha farashin
- CAS# 851199-59-2
Cikakken Bayani
- Sunan mahaifi: Linaclotide
- Saukewa: 851199-2
- Tsarin kwayoyin halitta: C59H79N15O21S6
- Bayyanar: farin foda
- Aikace-aikace: ana amfani da shi don magance maƙarƙashiya
- DeliveryTime: jigilar kaya da gaggawa
- PackAge: bisa ga bukatun abokin ciniki
- Port: Shenzhen
- Yawan samarwa: Kilogram 1/ Watan
- Tsafta: 98%
- Adana: 2 ~ 8 ℃. kariya daga haske
- Sufuri: ta iska
- Iyakar adadin: 1 gram
fifiko
Cikakkun bayanai
Samfurin: Linaclotide
Synonym: Linaclotide Acetate
Lambar CAS: 851199-59-2
Tsarin kwayoyin halitta: C59H79N15O21S6
Nauyin Kwayoyin: 1526.8
Bayyanar: Farin foda
Tsafta:> 98%
Jeri: NH2-Cys-Cys-Glu-Tyr-Cys-Cys-Asn-Pro-Ala-Cys-Thr-Gly-Cys-Tyr-OH
Linaclotide wani nau'in roba ne, peptide amino acid goma sha huɗu da agonist na nau'in guanylate cyclase na intestinal C (GC-C), wanda ke da alaƙa da tsarin dangin guanylin peptide, tare da sirrin sirri, analgesic da ayyukan laxative. Bayan gudanar da baki, linaclotide yana ɗaure zuwa kuma yana kunna masu karɓa na GC-C waɗanda ke kan luminal surface na epithelium na hanji. Wannan yana ƙara yawan ƙwayar guanosin monophosphate (cGMP), wanda aka samo daga guanosine triphosphate (GTP). cGMP yana kunna cystic fibrosis transmembrane conductance regulator (CFTR) kuma yana ƙarfafa ɓoyewar chloride da bicarbonate a cikin lumen na hanji. Wannan yana inganta haɓakar sodium a cikin lumen kuma yana haifar da ƙara yawan ƙwayar hanji. Wannan a ƙarshe yana haɓaka jigilar GI na abubuwan ciki na hanji, yana inganta motsin hanji kuma yana kawar da maƙarƙashiya. Ƙara matakan cGMP na waje na iya haifar da sakamako na antinociceptive, ta hanyar tsarin da ba a bayyana ba tukuna, wanda zai iya haɗa da daidaitawar nociceptors da aka samu akan filaye masu zafi na colonic afferent. Linaclotide ana ɗaukar shi kaɗan daga sashin GI.
