Samfurin: Linaclotide
Synonym: Linaclotide Acetate
CAS A'a.: 851199-59
Tsarin Abinci: C59H79N15o21s6
Nauyi na kwayoyin: 1526.8
Bayyanar: farin foda
Tsarkake:> 48%
Jerin: NH2-CYS-CYS-GLA-TYR-CYS-GLY-ALN-ALA-ALA-ALS-CACS-CLS-Gly-CLS

Linaclotide ne roba mai kyau, amino acid mai cinya nao acid da kuma agonist na hanji na hanji na hanun ciki, wanda aka kirkira da ya haifar da tsari na GCIYLINL PTPTED na farko, tare da asirin da ayyukan laxative. Bayan adawar baka, linaclotide ɗaure zuwa da kunna GC-C masu karɓa da ke cikin luminal a farfajiya na Epithelium na ciki. Wannan yana kara maida hankali game da Cyclic Guanosterine (CGMP), wanda aka samo daga Guanosine Triphosphate (GTP). CGMP Mayar da SPICROSMROSMUSMUMSMUMBRANSMEMBRANSMEMBRANSTMEMBRANE RUHU (CFR) kuma yana haɓaka ƙwayar chloride da Bicarbonate a cikin lumen hanji. Wannan yana haɓaka fitowar ruwan sodium a cikin lumen kuma yana haifar da ƙara ƙwayar ƙwayar hanji. Wannan ƙarshe yana hanzarta shigar da abubuwan da ke ciki na ciki, yana inganta motsi na hanji kuma yana sauƙaƙewa maƙarƙashiya. Yawan cgmpular cgmpular cgmpular na iya yin tasiri na maganin antinocIesptive, ta hanyar har yanzu ba cikakkiyar inji ce ta elucidated, wanda zai iya kunshi yiwuwar da aka samo akan zarbensin zafi. Linaclotide yana da kyau a hankali daga gicction.