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The Company applies ASC 718-10, “Share-Based Payment,” which requires the measurement and recognition of compensation expense for all share-based payment awards made to employees and directors, including employee stock options under the Company’s stock plans, based on estimated fair values. ASC 718-10 requires companies to estimate the fair value of equity-based payment awards on the date of grant using an option-pricing model. The value of the portion of the award that is ultimately expected to vest is recognized as expense over the requisite service periods in the Company’s consolidated statement of operations.

Emergent BioSolutions, Inc. (NYSE:EBS ) Emergent BioSolutions Inc. is a biopharmaceutical company focused on the development, manufacture and commercialization of immune-related biologic products, consisting of vaccines and therapeutics that assist the body’s immune system to prevent or treat disease. Emergent’s marketed product, BioThrax® (Anthrax Vaccine Adsorbed), is the only vaccine approved by the U.S. Food and Drug Administration for the prevention of anthrax infection. Emergent’s clinical pipeline includes programs focused on anthrax, botulism, typhoid, tuberculosis, hepatitis B and chlamydia.

Cell proliferation was determined by cell viability assay and EdU incorporation assay. Approximately 4 × 103 cells were seeded in triplicate in 96-well plates. Cell viability was assessed using the CellTiter 96 Aqueous One Solution Proliferation Assay Kit (Promega). EdU labeling was performed using the EdU Assay Kit (Ribobio, Guangzhou, China) as recommended by the manufacturer. Cell migration was determined by wound-healing assay as previously described7 by measuring the decreased width of the scratch.

As a precaution, to ensure that synthesis process changes or other factors have not resulted in systemic contamination of sartan drugs now on the market, the European Medicines Agency (EMA) will now expand its review of nitrosamine impurities to include four other widely-prescribed active ingredients: 

Upon the signing of the Samil Agreement, Samil paid the Company a gross upfront fee of approximately $2.1 million and in September], 2018, we received a milestone payment of $1.5 million. Samil has also agreed to pay additional clinical and regulatory-based milestone payments, which may aggregate to an additional $4.5 million, as well as tiered, double-digit royalties payable on sales (lower if sales of a generic equivalent commence in the Territory).

Li, Y. C. et al. Attenuating effect of post-treatment with QiShen YiQi Pills on myocardial fibrosis in rat cardiac hypertrophy. Clin Hemorheol Microcirc 51, 177–191, 10.3233/CH-2011-1523 (2012).

The work showed longer telomeres improves the health and lifespan of mice, which was surprising to some given the length of their telomeres, but agrees with the in vitro work by Shay and Wright showing gene expression changes as telomeres shorten. Interestingly this ties in roughly with expected lifespan: mice telomeres are 3 times longer than humans but shorten 90 times faster, so they live up to around 3 years rather than our 90. This much greater rate of telomere shortening is set by their much higher rate of MTOR, and probably much higher ROS too, which isn’t sufficently compensated for by their longer telomeres and active TERT (hence the benefits of the treatment). It is exactly the same problem we’ve been lookong at with CR and rapamycin, etc., but looked at from the other side.

emerging growth company, we are permitted and plan to rely on exemptions from certain disclosure requirements that are applicable to other public companies that are not emerging growth companies. These exemptions include not being required to comply with the auditor attestation requirements of Section 404 of the Sarbanes-Oxley Act of 2002, or SOX Section 404, not being required to comply with any requirement that may be adopted by the Public Company Accounting Oversight Board regarding mandatory audit firm rotation or a supplement to the auditor’s report providing additional information about the audit and the financial statements, reduced disclosure obligations regarding executive compensation and exemptions from the requirements of holding a nonbinding advisory vote on executive compensation and stockholder approval of any golden parachute payments not previously approved.

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The best example is the famous J curve for alcohol in which small amounts are beneficial at low doses for the heart and huge amounts are horrible (although a recent meta-analysis has challenged this [ Lancet vol. 392 pp. 1015 – 1035 ’18 ], but I don’t trust them — for why see http://science.sciencemag.org/content/sci/361/6408/1184.full.pdf.

QSYQ has been used in China for prevention and treatment of cardiac dysfunction10. However, our understanding of the mechanism for its beneficial role in CH and cardiac failure remains incomplete. The mechanisms so far reported accounting for the role of QSYQ in CH or cardiac failure include interference in inflammation12,17, oxidation and apoptosis18, but none of which has been accepted as a conclusive one. We speculate that as QSYQ is a compound medicine it will thus act via multiple mechanisms. To fully understand these mechanisms, a comprehensive strategy is needed instead of focusing only one or two aspects of the mechanisms. We thus undertook a proteomic analysis of cardiac tissues taken from different groups of rats and revealed a total of 54 spots (41 proteins) that altered significantly in the expression after drug treatments compared with AAS2M group. These proteins can be classified functionally into 8 groups, suggesting that QSYQ plays CH-protective role via a complex mechanism involving multiple processes, including those that have been reported respectively in different studies. More importantly, of the QSYQ-induced significantly altered proteins, 41% were related to energy metabolism and 22% to oxidative stress, indicating these two processes as the dominant mechanisms for QSYQ to exert effect on CH.