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We had negative cash flow from investing activities of approximately $60.0 million for the year ended December 31, 2018 as compared to a positive cash flow from investing activities of approximately $6.4 million for the year ended December 31, 2017. The negative cash flow from investing activities for the year ended December 31, 2018 was mainly due to investment in marketable debt securities in the amount of approximately $92.3 million, offset by maturity of marketable debt securities in the amount of approximately $38.4 million.
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Chatakun, P. et al. The effect of five proteins on stem cells used for osteoblast differentiation and proliferation: a current review of the literature. Cell Mol. Life Sci. 71, 113–142 (2014).
The following common stock equivalents were excluded from the calculation of net loss per share due to their anti-dilutive effect:
The BMSCs were cultured on tissue culture plastic (noted as Blank), PE, PAr and PArN. Four groups of BMSCs were harvested at day 1 and day 3 and the cells were treated with or without 5 μM 7-xylosyl-10-deacetylpaclitaxel. After incubation for 24 h, the cells were collected and stained with 50 μg/mL DAPI (Partec, Munster, Germany). The cell cycle distribution of 1 × 105 cells was determined by flow cytometry (Partec) and the cell cycle analysis was performed using FloMax software. The fractions of cells in the G0/G1, G2, and S phases of the cell cycle and proliferation index (PI) were analyzed.
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For example a standardized product may contain Willow (bark) 500 mg Willow (bark) Extract standardized to 15% salicin (60 mg) 400 mg
A deterioration in global economic conditions and uncertainties may have an adverse effect on our business. For instance, interest rates, the liquidity of the credit markets and the volatility of the capital markets could also affect the value of our investments, if any, and our ability to liquidate such investments in order to fund our operations. Interest rates and the ability to access credit markets could also adversely affect the ability of patients and distributors to purchase, pay for and effectively distribute Aramchol and any future product candidates.
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