Citation:  When referring to this article, please cite as C. Challener, “Steps Closer to the Adoption of Continuous Processing," Pharmaceutical Technology 40 (6) 2016.

(a) Representative tracings showed the vasorelaxant effects of β-BA (200 mg/kg/d) in phenylephrine pre-contracted aortic rings. β-BA induced relaxation could be significantly attenuated when the endothelium intact specimens were exposed to L-NAME (10−4 M). The values of results are expressed as Means ± SD (n = 8). Experimental groups: control (■), model (⧫), model + β-BA 200 mg/kg (▲), model + β-BA 200 mg/kg + L-NAME (○). ##p < 0.01 versus the control group, #p < 0.05 versus the control group, **p < 0.01 versus the model group, *p < 0.05 versus the model group. (b) si-con and si-eNOS were transfected to HUEVCs for 12 h, then the cells were pretreated with β-BA for 24 h before being subjected to 6 h OGD then incubated with β-BA for an additional 24 h. Expression of eNOS was determined. Cell viability was measured with MTT assay. The data represent the results of (Mean ± SD) of triplicate independent experiments. ##p < 0.01 versus the control group, **p < 0.01 versus OGD group, p < 0.01 versus β-BA group.

        We have not recorded a provision for federal or state income taxes as we have had cumulative net operating losses since inception.

The 2017 Amendment was enacted as part of the Economic Efficiency Law that was published on December 29, 2016, and is effective as of January 1, 2017. The 2017 Amendment provides new tax benefits for two types of “Technology Enterprises”, as described below, and is in addition to the other existing tax beneficial programs under the Investment Law.

Kolisek, M., Beck, A., Fleig, A. & Penner, R. Cyclic ADP-ribose and hydrogen peroxide synergize with ADP-ribose in the activation of TRPM2 channels. Mol. Cell 18, 61–69 (2005).

Cardiac hypertrophy (CH) is initially an adaptive response to pressure or volume stress, which is characterized by increased cardiomyocyte size, re-expression of fetal genes, and activation of signaling pathways governing protein synthesis1. However, persistent and severe CH becomes a maladaptive response and ultimately contributes to subsequent heart failure2 that is a major and growing public health concern, as well as a leading cause of morbidity and mortality worldwide3. Thus, it is critical to suppress CH timely to prevent the progression of CH to heart failure.

抗雌激素：此类药物阻滞雌激素的效应。由于雌激素依赖性的肿瘤需要雌激素促进生长，因此可由此类药物治疗。

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Definitely. Maybe Yamanaka could be one of them if epigenetic reprogramming turns out to be the next big thing in anti-aging.

        Both before and after approval of any product, we and our suppliers, contract manufacturers and clinical investigators, among others, are subject to extensive regulation by governmental authorities in the U.S. and other countries, covering, among other things, testing, manufacturing, quality control, clinical trials, post-marketing studies, labeling, advertising, promotion, distribution, import and export, governmental pricing, price reporting and rebate requirements. Failure to comply with applicable requirements could result in one or more of the following actions: warning letters; unanticipated expenditures; delays in approval or refusal to approve a product candidate; product recall or seizure; interruption of manufacturing or clinical trials; operating or marketing restrictions; injunctions; criminal prosecution and civil or criminal penalties including fines and other monetary penalties; exclusion from governmental healthcare programs, adverse publicity; and disruptions to our business. Further, government investigations into potential violations of these laws would require us to expend considerable resources and face adverse publicity and the potential disruption of our business even if we are ultimately found not to have committed a violation.

For cash bonuses granted to Mr. Baharaff see “Item 6. Directors, Senior Management and Employees— B. Compensation—Individual Compensation of Covered Executives.” For outstanding equity-based awards granted to Mr. Baharaff see below under “Item 6. Directors, Senior Management and Employees—E. Share Ownership—Certain Information Concerning Equity Awards to Office Holders.”