If applicable, the penny stock rules may make it difficult for investors to sell their ordinary shares. Because of the rules and restrictions applicable to a penny stock, there is less trading in penny stocks and the market price of our ordinary shares may be adversely affected. Also, many brokers choose not to participate in penny stock transactions. Accordingly, investors may not always be able to resell their ordinary shares publicly at times and prices that they feel are appropriate and the market price of our ordinary shares may be adversely affected.
Hi Mark Your comments on fat deposits are pretty original. Concerning body fat, 90% of fat is subcutaneous, 10% is visceral. Visceral fat acts as an endocrine organ and gives off the very inflammatory cytokines, they also produce precursors to angiotensin ( another aging pathway), and lastly they produce retinal-binding proteins which increase insulin resistance (RBP4). They are developing a blood test for rbp4 it’s so linked to visceral fat. As you suggest, subcutaneous fat is a different animal and produces both leptin and adiponectin to control appetite and reduce body fat. So you’re on the right track. It is true that we lose ” baby fat” as we age. Do you have any theories about it ?
Raising additional capital may cause dilution to our stockholders, restrict our operations or require us to relinquish rights to our technologies or product candidates.
Barbuti, A. et al. Localization of pacemaker channels in lipid rafts regulates channel kinetics. Circ Res 94, 1325–31 (2004).
Hua, Y., Zhang, Y. & Ren, J. IGF-1 deficiency resists cardiac hypertrophy and myocardial contractile dysfunction: role of microRNA-1 and microRNA-133a. J. Cell. Mol. Med. 16, 83–95, 10.1111/j.1582-4934.2011.01307.x (2012).
Hi I Aldebaran, AD is 2 hot disease with first hit being severe damage to micro vascular system. Second hit is amyloid cascDe with Tau. Late problem is microfilm activation which causes chronic inflammation which causes more damage. Want to lower activity microfilm not increase, but this late stage and will not help. I rate their chance for success less than zero.
Additional clinical trials may divert a significant amount of Company resources and may ultimately be unsuccessful.
CR, resveratrol, and rapamycin all inhibit m TOR, all protect against age-related disease, and all induce autophagy as well as inhibit senescence.
If we are sued for infringing intellectual property rights of third parties, such litigation could be costly and time consuming and could prevent or delay us from developing or commercializing our product candidates.
Hogman, M., Frostell, C., Arnberg, H. & Hedenstierna, G. Bleeding time prolongation and NO inhalation. Lancet. 341, 1664–1665 (1993).
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ITEM 5. MARKET FOR REGISTRANT’S COMMON EQUITY, RELATED STOCKHOLDER MATTERS AND ISSUER PURCHASES OF EQUITY SECURITIES
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