General and administrative expenses consist primarily of employee related expenses, including salaries, benefits, and stock-based compensation, for personnel in executive, finance, facility operations and administrative functions. Other significant costs include facility costs not otherwise included in research and development expenses, legal fees relating to patent and corporate matters, and fees for accounting, tax and consulting services.

To date, we have not generated revenue from the sale of any product, excluding the licensing revenue we recorded in connection with the Samil Agreement, and we do not expect to generate any significant revenue other than the amortization of the upfront payments under the license agreement with Samil and of the subsequent royalties and/or milestones that may be earned in connection with the Samil Agreement or potential other license Agreements, unless and until we commercialize Aramchol, or license the product to additional third parties. As of December 31, 2018, the Company had an accumulated deficit of approximately $86.5 million.

stock-based compensation expense; partially offset by a decrease in net operating losses and a lower U.S. federal tax rate due to the TJCA.

why did you write that you missed the OSKM rejuvenation paper? You reported it in december 2016https://joshmitteldorf.scienceblog.com/2016/12/23/from-santa-diego-a-jolla-xmas-gift/

Our executive offices are located in Tel Aviv, Israel. In addition, the majority of our officers and directors are residents of Israel. Accordingly, political, economic and military conditions in Israel may directly affect our business. Since the establishment of the State of Israel in 1948, a number of armed conflicts have taken place between Israel and its neighboring countries. Any hostilities involving Israel or the interruption or curtailment of trade between Israel and its trading partners could adversely affect our operations and results of operations. In recent years, these have included hostilities between Israel and Hezbollah in Lebanon and Hamas in the Gaza strip, both of which resulted in rockets being fired into Israel, causing casualties and disruption of economic activities. In addition, Israel faces threats from more distant neighbors, in particular, Iran.

(a) Antitumor effects of Cd38+/+ and Cd38−/− NK cells in a lung metastasis model of B16F10 cells. C57BL/6 mice (n = 4 per cohort) were injected i.v. with 1 × 105 B16F10 melanoma cells. After 2 d, IL-2 activated NK cells (2 × 106 cells) from Cd38+/+ or Cd38−/− mice were injected i.v. into B16F10-bearing wild-type mice. Lungs were harvested 14 d later and metastatic nodules were counted. nd, not detected. Data are mean ± SEM of three independent experiments. Representative images of lungs are shown. *P < 0.001. (b) Comparison of cytolytic activity of Cd38+/+ and Cd38−/− NK cells against various target cell lines. Cd38+/+ or Cd38−/− NK cells cultured for 10 d were assessed for cytolytic activity as indicated, over 4 h. Data are mean ± SEM of three independent experiments. *P < 0.001; #P < 0.05. (c and d) Cd38+/+ and Cd38−/− NK cells are expressed equivalent amounts of perforin and granzyme B at mRNA (c) and protein levels (d). The gels have been run under the same experimental conditions. The full-length blots and the cropped blots are presented in Supplementary Figure 4. Data are mean ± SEM of three independent experiments. ns, not significant. (e) Comparison of the amount of granzyme B released into the media by Cd38+/+ and Cd38−/− NK cells on stimulation with B16F10 cells for 30 min. Data are mean ± SEM of three independent experiments. *P < 0.001 vs basal; #P < 0.05.

First China Pharmaceutical Group, Inc. (OTCBB:FCPG) aims to develop a high growth pharmaceutical distribution company generating significant revenue from the sale of healthcare products in China. As part of its business strategy, the Company has acquired the assets of Kun Ming Xin Yuan Tang Pharmacies Co. Ltd. (XYT), which includes a strategic advantage over its competitors as it is one of a handful of pharmaceutical distribution companies in Yunnan Province that has obtained government approval to market and fill orders using the internet. First China Pharmaceutical Group plans to continue the rapid growth of the company from its current position as a provider of approximately 7,100 drugs to more than 4,700 pharmacies, hospitals and clinics in China’s Yunnan Province.

        We also have a fully paid-up, non-exclusive license to more than 20 U.S. and more than 50 foreign granted patents directed to various display library technologies as a result of our acquisition of Cosmix Verwaltungs GmbH, or Cosmix, which covers other rights related to our Extreme Diversity platform. These include patents that have been granted in the U.S., Canada, China, Europe, India, Israel, Japan,

The patent portfolio for Aramchol contains patents and pending patent applications directed to composition of matter, manufacturing methods and methods of use. We own six U.S. patents, and corresponding foreign patents and pending patent applications, as detailed below.

Thanks Akshay, yes indeed there are other ways to get rid of iron and/or chelate it. I’m just pointing out one of aspirin’s likely other mechanisms. Yes also that willow bark could and probably does have other components that are important. Some research concluded that the salicylate in willow couldn’t possibly account for all of its painkilling ability since there’s too little compared to aspirin.

We will require substantial additional financing to achieve our goals, and a failure to obtain this necessary capital when needed on acceptable terms, or at all, could force us to delay, reduce or eliminate our product discovery and development programs or commercialization efforts.

The unrecognized compensation expense calculated under the fair-value method for stock options expected to vest as of December 31, 2018 and 2017 is approximately $99 thousand and $193 thousand, respectively, and is expected to be recognized over a weighted-average period of one year and two years, respectively.