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        We expect to enter into additional collaborations for the development and commercialization of certain of our product candidates. If we enter into such collaborations, we will have limited control over the amount and timing of resources that our collaborators will dedicate to the development or commercialization of our product candidates. Our ability to generate revenues from these arrangements will depend on any future collaborators’ abilities to successfully perform the functions assigned to them in these arrangements. In addition, any future collaborators may have the right to abandon research or development projects and terminate applicable agreements, including funding obligations, prior to or upon the expiration of the agreed upon terms.

        Moreover, because the issuance of a patent is not conclusive as to its inventorship, scope, validity or enforceability, our patents or pending patent applications may be challenged in the courts or patent offices in the U.S. and abroad. There is no assurance that all of the potentially relevant prior art relating to our patents and patent applications has been found. If such prior art exists, it may be used to invalidate a patent, or may prevent a patent from issuing from a pending patent application. For example, such patent filings may be subject to a third-party preissuance submission of prior art to the U.S. Patent and Trademark Office, or USPTO, or to other patent offices around the world. It is often the case that such third-party submissions may be made anonymously such that we would not have information regarding the name of the party challenging our intellectual property. Alternately or additionally, we may become involved in post-grant review procedures, oppositions, derivations, proceedings, reexaminations, inter partes review or interference proceedings, in the U.S. or elsewhere, challenging patents or patent applications in which we have rights, including patents on which we rely to protect our business. An adverse determination in any such challenges may result in loss of exclusivity or in patent claims being narrowed, invalidated or held unenforceable, in whole or in part, which could limit our ability to stop others from using or commercializing similar or identical technology and products, or limit the duration of the patent protection of our technology and products. In addition, given the amount of time required for the development, testing and regulatory review of new product candidates, patents protecting such candidates might expire before or shortly after such candidates are commercialized.

Bio-Path Holdings, Inc. (OTC:BPTH ) is a biotechnology company focused on developing therapeutic products utilizing its proprietary liposomal delivery technology designed to systemically distribute nucleic acid drugs throughout the human body with a simple intravenous transfusion. Bio-Path’s lead product candidate, Liposomal Grb-2, is in a Phase I study for blood cancers. The Company announced its plans to conduct three Phase II clinical trials of Liposomal Grb-2 in combination with frontline therapy in AML, CML and MDS. In addition, Bio-Path plans to develop Liposomal Grb-2 for preoperative treatment and for metastasis in triple negative and inflammatory breast cancer patients. Bio-Path’s second drug candidate, also a liposomal antisense drug, is ready for the clinic where it will be evaluated in lymphoma and solid tumors. These product candidates and the delivery technology have been licensed from The University of Texas MD Anderson Cancer Center.

Hi Lindy, A few words in defense of my fellow physicians: Doctors follow what is in medical textbooks. Medical textbooks don’t recognize aging as disease and have zero discussion of aging. As far as medicine is concerned, aging is natural condition; end of story. Also almost all doctors believe in human clinical trials for translation of basic science into office practice. Rapamycin is generic drug so nobody spending hundreds of millions of dollars on clinical trials. Also doctors are busy. They read journals in their specialty. They don’t read basic science stuff. So very hard for physician to discover Blagosklonny. Realize Blagosklonny is greatest scientist since Charles Darwin and then become expert on Rapamycin. Also no medical literature explaining how to use Rapamycin as anti aging drug. Also getting old and getting sick is a trillion dollar industry. What would happen if old people refused to get sick.

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ChIP assays were carried out using the EZ ChipTM Assay kit (Millipore) according to the manufacturer’s instructions. Briefly, cells were crosslinked with 1% formaldehyde at room temperature for 15 min, washed twice in PBS and lysed in SDS lysis buffer. Chromatin fragments were prepared by sonicating lysates on ice. Then, lysates were incubated with antibodies against HIF-1α, HIF-2α (Novus Biologicals), RNA polymerase II, or IgG (Millipore). Immunoprecipitated complexes were collected using protein G-agarose beads. The pellets were washed with Elution buffer and incubated at 65 °C for 4 h to reverse the cross-link by formaldehyde. They were then digested with 50 μg/ml proteinase K for 1 h. Dissociative DNA were purified using the Cycle Pure Kit (Omega) and subjected to PCR amplification. The primers used for amplification of the HRE and negative control segments of the promoter were as follows: HRE, 5 -AGG AAA TGA ATC AAT GTA AC -3 (forward) and 5- TAA GCA ACT CCA CCA AAA -3 (reverse); negative control, 5- TCC GCT CTT CTT CCC TCA -3 (forward) and 5– TGC GAA GCT GCT CAG TCG -3 (reverse).

Pursuant to Israeli law, an internal auditor’s tenure cannot be terminated without his or her consent, nor can he or she be suspended from such position unless the board of directors of the company has so resolved following the recommendations of the company’s audit committee and, after providing the internal auditor with the opportunity to present his or her position to the board of directors of the company and to the audit committee.

Yang, X. et al. Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension. Circ. Res. 96, 1053–1063 (2005).

Our ability to become profitable depends upon our ability to generate revenue in excess of our expenses. To date, we have not generated any revenue, excluding the licensing revenue we recorded in connection with that certain Samil Agreement (as defined below), as our product candidate, Aramchol, is still in clinical development and has not been approved by the FDA, nor has any other product candidate. We do not know when, or if, we will generate any revenue from sales of Aramchol and any future product candidates, if any. We do not expect to generate revenue other than subsequent royalties and/or milestones that can be earned in connection with the Samil Agreement or other potential license agreements, unless and until we, or an ultimate third-party licensor or acquirer, obtain regulatory and marketing approval of, and commercialize, Aramchol, and any future product candidates. We will continue to incur significant research and development and general and administrative expenses related to our operations. We expect to continue to incur losses for the foreseeable future, which may be significant, and these losses will likely increase as we:

Hi Aldebaran If brand name drug and unlimited millions, very easy. Only people at risk E4 carriers and study treatment only for them. Use PET scan for glucose metabolism. Also PETs an for amyloidBeta. Also clinical testing memory. However, because generic no money for tests. Only way is off label. Note E4 have 2-3 times the risk and onset 10 years sooner.

        Our commercial success may depend in part on our ability to obtain and maintain patent and other proprietary protection for our product candidates, technology, and know-how, defend and enforce our patents, prevent others from practicing our technology by enforcing our proprietary rights, preserve the confidentiality of our trade secrets, and operate without infringing the proprietary rights of others.