The pre-specified primary efficacy endpoint was the change in QMG score, a physician-administered assessment of MG-related muscle weakness, from baseline to week 12. The key secondary efficacy endpoint was the change in MG Activities of Daily Living, or MG-ADL, score, a patient-reported outcome measure, from baseline to week 12. Significance testing was pre-specified at a 1-sided alpha of 0.1.

How to cite this article: Chen, Y.-Y. et al. QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode. Sci. Rep. 5, 11802; doi: 10.1038/srep11802 (2015).

        We completed our Phase 2 clinical program for zilucoplan in PNH patients in the second quarter of 2017 and announced top-line data in February 2018. During the second and third quarters of 2018, we held End-of-Phase 2 discussions with the FDA, the MHRA, and Health Canada. Based on FDA feedback, as well as advice provided by MHRA and Health Canada, we announced the design of a single-arm Phase 3 study in treatment-naïve PNH patients. In January 2019, we concluded scientific advice and protocol design discussions with the EMA. The EMA was not receptive to a single-arm study design to support approval of zilucoplan in PNH. We do not plan to alter the design of the Phase 3 PNH program, but are reassessing the likelihood of obtaining marketing authorization for PNH in the E.U.

BioCryst Pharmaceuticals Inc. (NasdaqGM: BCRX ) BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for influenza and lymphoma.

The Companies Law further stipulates that directors who are not qualified to serve on the audit committee, as described above, may not serve on the remuneration committee either and that similar to the audit committee, generally, any person who is not entitled to be a member of the remuneration committee may not attend the remuneration committee’s meetings. Our Board has adopted a remuneration committee charter setting forth the responsibilities of our remuneration committee, as described below.

I find your idea that can decease inflammation by increase of subcutaneous adipose tissue a very novel idea. Furthermore, since in humans, excess fat is generally stored as as midline abdominal fat, doesn’t seem any way to increase subcutaneous fat beyond normal physiologic amount, without increasing abdominal fat. In short, you seem to be proposing something which as far as I know, is impossible.

Catalent announces investment for its Zydis ODT technology, offering increased drug load and taste-masking capabilities.

        As of December 31, 2018, we had used $84.2 million of the net proceeds from our IPO.

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Moussaieff, A. & Mechoulam, R. Boswellia resin: from religious ceremonies to medical uses; a review of in-vitro, in-vivo and clinical trials. J Pharm Pharmacol. 61, 1281–1293 (2009).

Renal fibrosis is the final outcome for almost all patients with CKD, for which there are no effective and affordable therapeutic options in the clinical setting, thus creating a heavy socioeconomic burden. Based on the data in this study, we hypothesize that P311 regulates renal fibrogenesis because (1) P311 levels were significantly increased and P311 seem to be co-localized with TGF-β1- and α-SMA-positive regions in renal fibrosis; (2) interstitial collagen deposition, vimentin and α-SMA expression and macrophage infiltration decreased in P311-deficient mice in a mouse model of UUO-induced fibrosis; and (3) P311 deficiency down-regulated tubular TGF-β1 expression, TGF-β1 receptor expression and TGF-β1/Smad signaling activation. This study demonstrate that P311 expression modulates renal fibrogenesis.

Thanks for pointing out the more recent works from Blasco. I will look at it. Regardless of its applicability to Alzheimer, I have found the mice study of 2012 convincing.