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To our knowledge, as of February 28, 2019, we had two holders of record of our ordinary shares with a U.S. address, including Cede & Co., the nominee of The Depository Trust Company. These holders held in the aggregate 16,640,467 ordinary shares, or 78.8% of our outstanding ordinary shares as of February 28, 2019. The number of record holders in the United States is not representative of the number of beneficial holders of our ordinary shares nor is it representative of where such beneficial holders are resident since many of these ordinary shares were held by brokers or other nominees.

Cangene Corporation (TSX:CNJ.TO) is one of Canada’s largest and earliest biopharmaceutical companies. It was founded in 1984 and is headquartered in Winnipeg, Manitoba. Cangene has approximately 700 employees in eight locations across North America and its products are sold worldwide. It operates three large manufacturing facilities – two in Winnipeg, Manitoba and one in Baltimore, Maryland – where it produces its own products and undertakes contract manufacturing for a number of companies. Cangene operates three U.S. and one Canadian plasma-collection facilities branded as Cangene Plasma Resources In addition, it has a regulatory affairs, sales and corporate communications office in Toronto, Ontario. Cangene is focused on developing therapeutics for infectious diseases, and the Company uses patented manufacturing processes to produce plasma-derived and recombinant therapeutic proteins. Cangene has five FDA and/or Health Canada-approved products. In addition, the Company has several more products in development at various stages. Three of Cangene’s products have been accepted into the U.S. Strategic National Stockpile – botulism antitoxin (investigational product), anthrax immune globulin (investigational product) and vaccinia immune globulin, a product used to counteract certain complications that may arise from smallpox vaccination. Capitalizing on its drug manufacturing expertise, Cangene also operates a significant contract research and manufacturing business using the resources of Baltimore, Maryland-based Cangene bioPharma, Inc . (a wholly owned subsidiary; formerly Chesapeake Biological Laboratories, Inc.)

        Research and development expenses comprise costs incurred in performing research and development activities, including salaries, benefits and other employee-related expenses, share-based compensation expense, laboratory supplies and other direct expenses, facilities cost, overhead costs, third-party contract costs relating to pre-clinical studies and clinical trial activities and related contract manufacturing expenses, and other outside costs.

On January 28, 2019, FDA provided an update on the investigation into the presence of nitrosamine impurities, including N-Nitrosodimethylamine (NDMA) and N-Nitrosodiethylamine (NDEA), in some generic versions of angiotensin II receptor blocker (ARB) medicines, which treat high blood pressure and heart failure. According to FDA, while the risk to patients is low, these impurities are probable carcinogens and should not be present in drug products.

As an alternative to pioglitazone the active ingredients of magnolia (particularly magnolol) have shown ability to increase adipogenesis in human adipose mesenchymal stem cells, at least in vitro. See free paper ‘Magnoliae officinalis extracts promote adiponectin production during adipogenesis in human adipose tissue-mesenchymal stem cells’.

Abviva, Inc ( OTCPK:ABVV) was established to develop and commercialize diagnostic and therapeutic products from a novel breast cancer growth inhibitory protein. Research scientists at the prestigious University of Michigan Cancer Center discovered a secreted protein produced in normal breast epithelial cells that inhibits the growth of breast cancer. This discovery was developed into a diagnostic blood test for breast cancer, Mammastatin Serum Assay (MSA). The MSA will be used to screen women for early detection of breast cancer. In clinical studies Mammastatin was found to be normally present in blood serum of healthy women and absent in women with breast cancer. Abviva intends to offer the MSA to women and their doctors through its wholly owned clinical reference laboratory, Biomedical Diagnostics, LLC.

Cord Blood America (OTCBB:CBAI ) is the parent company of CorCell, which facilitates umbilical cord blood stem cell preservation for expectant parents and their children. Its mission is to be the most respected stem cell preservation company in the industry. Collected through a safe and non-invasive process, cord blood stem cells offer a powerful and potentially life-saving resource for treating a growing number of ailments, including cancer, leukemia, blood, and immune disorders.

        On October 31, 2016, we completed an initial public offering ("IPO"), in which we issued and sold 7,049,230 shares of our common stock at a public offering price of $13.00 per share, resulting in net proceeds to us of $82.8 million after deducting $6.4 million of underwriting discounts and commissions and offering costs of $2.4 million. On November 29, 2016, we completed the sale of an additional 1,057,385 shares of common stock to the underwriters under the underwriters’ option in the IPO to purchase additional shares of common stock at the public offering price of $13.00 per share, resulting in additional net proceeds to us of $12.8 million after deducting underwriting discounts and commissions of $1.0 million.

(a, c) Representative images of wound-healing assay showing migration of rat PASMC either with miR-322 overexpression or knockdown. (b, d) Bar chart showing relative decreased wound width after 24 h. Data are shown as mean ± SD. *p < 0.05 compared to miR-Con or anti-Con.

New York, NY – Point Roberts, WA – August 14, 2014 (Investorideas.com Newswire) Investorideas.com staff: Investorideas.com, a global news source covering leading sectors issues the updated biotech stock directory for August.

cAMP levels were determined by a cAMP immunoassay kit according to the manufacturer’s protocol (Enzo Life Science). NK cells were preincubated with 0.5 mM isobutylmethylxanthine, a phosphodiesterase inhibitor. After incubation with PME for the indicated times, the cells were lysed in 0.1 M HCl to stop the reaction. After centrifugation at 20,000 × g for 10 min at 4°C, supernatants were collected and acetylated, and immunoassays were performed.