We determined that the transaction price at contract inception was $2.1 million consisting of the upfront, non-refundable payment. None of the clinical or regulatory milestones were included in the transaction price upon inception, as all milestone amounts were fully constrained. Management assessed that the likelihood of occurrence of the other performance obligations in the Samil Agreement was remote upon contract inception. As such, the standalone value of such performance obligations was deemed de minimis and none of the transaction price was allocated to those obligations. Any consideration related to sales-based milestones and royalties will be recognized when the related sales occur, and therefore have also been excluded from the transaction price.
We do not independently conduct clinical trials of any of our product candidates. We rely on third parties, such as contract research organizations, or CROs, clinical data management organizations, medical institutions and clinical investigators, to conduct these clinical trials and expect to rely on these third parties to conduct clinical trials of any other product candidate that we develop. Any of these third parties may terminate their engagements with us under certain circumstances. We may not be able to enter into alternative arrangements or do so on commercially reasonable terms. In addition, there is a natural transition period when a new contract research organization begins work. As a result, delays would likely occur, which could negatively impact our ability to meet our expected clinical development timelines and harm our business, financial condition and prospects.
Vladimirova-Kitova, L. G. & Deneva-Koycheva, T. I. The effect of simvastatin on asymmetric dimethylarginine and flow-mediated vasodilation after optimizing the LDL level: a randomized, placebo-controlled study. Vascular pharmacology 56, 122–130, doi: 10.1016/j.vph.2011.10.004 (2012).
Provisions in our corporate charter documents and under Delaware law may prevent or frustrate attempts by our stockholders to change our management or hinder efforts to acquire a controlling interest in us.
2. Linear no-threshold model — now matter how lot the dose, damage is seen. This is obviously crazy (see #1 above) but apparently is used by the EPA for carcinogens.
Dragan, S., Serban, M. C. & Banach, M. Proprotein Convertase Subtilisin/Kexin 9 Inhibitors: An Emerging Lipid-Lowering Therapy? Journal of cardiovascular pharmacology and therapeutics , doi: 10.1177/1074248414539562 (2014).
Zhao, L. et al. Identification of P311 as a potential gene regulating alveolar generation. American journal of respiratory cell and molecular biology . 35, 48–54 (2006).
Endothelial dysfunction is an early event in atherogenesis characterized by decreased availability of nitric oxide (NO), which diffuses towards the vascular smooth muscle tissues (VSMCs), triggers a rise of intracellular cyclic guanosine monophosphate (cGMP), leading to vasorelaxation1. Endothelial dysfunction may be associated with increased circulating asymmetric dimethylarginine (ADMA) levels – an L-arginine analogue, which inhibits NO formation2. ADMA is a pan-inhibitor of all 3 NO synthases (NOS) isoforms (potent noncompetitive inhibitor of neuronal NOS and week inhibitor of inducible and endothelial NOS)3 and its plasma concentrations in the general population is 0.4–0.7 μM4.
3. Based on my knowledge, the financial statements, and other financial information included in this report, fairly present in all material respects the financial condition, results of operations and cash flows of the Company as of, and for, the periods presented in this report;
Due to Western sanctions over the Russian annexation of Crimea; long-lasting tensions over Russian support for pro-independence fighters in eastern Ukraine; Russian anger over the promotion of Color Revolutions in its backyard, especially Georgia; and Russian weapons that were allegedly involved in the shooting down of a Malaysian Airlines jetliner that had killed all onboard; Russo-EU ties are strained. Russo-US ties are also strained for the same reason but the US under the Trump administration is keen to reach rapprochement with the Russians. In fact, in his meeting with NATO allies, President Trump pushed hard for the revival of the G-8 (the G-7 plus Russia). President Trump is trying very hard to reboot American relations with the Russians, something of great significance between the world’s top two nuclear powers armed with enough ICBMs to destroy the world many times over. President Trump’s overtures are resisted by many: his Democrat colleagues, European leaders and his own intelligence services. This is a complicated situation.
Kokkiripati, P. K. et al. Gum resin of Boswellia serrata inhibited human monocytic (THP-1) cell activation and platelet aggregation. J Ethnopharmacol. 137, 893–901 (2011).
So actually if you use them all at once you’ll blast TOR pretty good and seemingly in an additive manner.
QiShenYiQi Pills, a compound in Chinese medicine, protects against pressure overload-induced cardiac hypertrophy through a multi-component and multi-target mode | Pramlintide Acetate Gmp Exporter Related Video:
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