Pursuant to our Articles, if at any time the share capital is divided into different classes of shares, the Company may by shareholder resolution, unless otherwise provided by the terms of issue of the shares of that class, modify, convert, broaden, add or otherwise alter the rights, privileges, advantages, restrictions and provisions related or unrelated at that time to the shares of any class with the sanction of a resolution passed by a simple majority of those present, personally or by proxy, and voting thereon at a separate general meeting of the holders of the shares of that class. Such majority approval is consistent with Israeli law.

        We meet the Securities and Exchange Commission’s ("SEC’s") definition of a "Smaller Reporting Company," and therefore qualify for the SEC’s reduced disclosure requirements for smaller reporting companies.

Fujitani, M. et al. P311 accelerates nerve regeneration of the axotomized facial nerve. Journal of neurochemistry. 91, 737–744 (2004).

To further gain insight into the mechanism for the effect of different treatments on energy metabolism in CH, we determined the expression of 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFK2), Carnitine palm acyltransferase 1A (CPT1A) and pyruvate dehydrogenase (PDH) in different groups; the results are presented in Fig. 6. As a glycolysis regulator, PFK2 increased significantly in AAS groups, which was protected by QSYQ, ASIV mono- and ASIV containing combination treatments but not others (Fig. 6a,b). In contrast, CPT1A, an enzyme involved in fatty acid oxidation, significantly reduced in AAS groups compared to Sham, which was restored by all the treatments except DLA and R1 mono-therapy or their combination with ASIV (Fig. 6a,c). PDH, a key enzyme of glucose oxidation, significantly decreased in AAS groups as well compared to Sham. All drug treatments but DO restored the expression of PDH as compared to AAS2M group (Fig. 6a,d).

Huang, Y. et al. Cardiac systolic and diastolic dysfunction after a cholesterol-rich diet. Circulation 109, 97–102 (2004).

I have a question for you. Suppose you have a great preventive treatment for Alzheimer but you need to start it very early (40 years old for example). On which basis can FDA approves it? Could PET scan be convincing enough? Animal models? Obviously trials cannot measure success on AD itself right?

Even if we complete the necessary pre-clinical studies and clinical trials, the marketing approval process is expensive, time consuming and uncertain and may prevent us or any future collaborators from obtaining approvals for the commercialization of some or all of our product candidates. As a result, we cannot predict when or if, and in which territories, we, or any future collaborators, will obtain marketing approval to commercialize a product candidate.

Following echocardiographic analysis two months after AAS, animals (n = 6) underwent thoracotomy, and MBF was measured by Laser-Doppler Perfusion Imager (PeriScan PIM3, Perimed, Sweden) equipped with a computer. All images were evaluated with the software LDPIwin 3.1 (Perimed, Sweden)40. For each animal, MBF was the average of three independent measurements.

The Company only applies the five-step model to contracts when collectability of the consideration to which the Company is entitled in exchange for the goods or services transferred to the customer is determined to be probable. At contract inception, once the contract is determined to be within the scope of the new revenue standard, the Company assesses whether the goods or services promised within each contract are distinct and, therefore, represent a separate performance obligation. Goods and services that are determined not to be distinct are combined with other promised goods and services until a distinct bundle is identified. The Company then allocates the transaction price (the amount of consideration the Company expects to be entitled to from a customer in exchange for the promised goods or services) to each performance obligation and recognizes the associated revenue when (or as) each performance obligation is satisfied. The Company’s estimate of the transaction price for each contract includes all variable consideration to which we expect to be entitled.

O.F. performed experiments. O.F and N.D. designed experiments, analyzed the data, wrote the manuscript and prepared figures.

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        (d)   Disclosed in this report any change in the registrant’s internal control over financial reporting that occurred during the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal quarter in the case of an annual report) that has materially affected, or is reasonably likely to materially affect, the registrant’s internal control over financial reporting; and