The Nasdaq Capital Market corporate governance requires each company adopting a nominating committee to certify that it has adopted a formal written charter or board resolution, as applicable, addressing the nominations process and such related matters as may be required under U.S. federal securities laws. Although not required as a foreign private issuer to adopt a nominating committee, we have decided to follow such requirement.

        Our future funding requirements, both short-term and long-term, will depend on many factors, including:

If we are unable to protect the confidentiality of our trade secrets, the value of our technology could be negatively impacted and our business would be harmed.

why did you write that you missed the OSKM rejuvenation paper? You reported it in december 2016https://joshmitteldorf.scienceblog.com/2016/12/23/from-santa-diego-a-jolla-xmas-gift/

        Net cash used in operating activities was $54.9 million for the year ended December 31, 2018 compared to $46.8 million for the year ended December 31, 2017. The increase in net cash used in operations was primarily attributable to a $10.5 million increase in our net loss as a result of higher operating expenses, primarily in connection with our pre-clinical studies and clinical trials related to our lead program zilucoplan and other research and development pipeline programs; partially offset by higher non-cash expenses, including depreciation, amortization and stock-based compensation and a net increase in operating liabilities.

The Blood Stasis Syndrome model was produced as described previously48. Briefly, rats were kept in plastic cages at 22 ± 2 °C with free access to pellet food and water and on a 12 h light/dark cycle. Rats were randomly divided into four groups (control group, model group, model +β-BA100 mg/kg and model +β-BA 200 mg/kg group) with eight animals in each. Rats were given blank solvent as the vehicle at the same volume for control group. Rats were given blank solvent at the same volume for model group. In the model +β-BA (100 mg/kg) group, rats were given 100 mg/kg β-BA. In the model +β-BA (200 mg/kg) group, rats were given 200 mg/kg β-BA. All treatments were performed by gavage and were administered seven times with an interval of 12 h. After the fifth administration, the model rats except those in control group with blood stasis were established by being placed in ice-cold water (0–2 °C) for 5 min, during the interval between two injections of adrenaline hydrochloride (0.8 mg/kg). Rats were fasted overnight and administration continued after performing the model. Blood samples and carotid artery were collected 30 min after the last administration on the following day.

Fernandez-Velasco, M. et al. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts. J Physiol 553, 395–405 (2003).

        There are a number of currently marketed products and product candidates in pre-clinical research and clinical development by third parties to treat the various diseases that we are targeting. In general, these products and product candidates can be categorized based on their proposed mechanisms of action. The mechanisms of action for these product candidates include inflammation suppression by agents such as complement inhibitors and corticosteroids, as well as immune modulators, visual cycle modulators, anti-amyloid agents, antioxidants, neuroprotectants, cell and gene therapies, and vascular and interstitial tissue remodeling agents.

(a) Cd38+/+ or Cd38−/− NK cells stimulated with B16F10 tumor cells. The percentage of conjugation formation at indicated time was analyzed by flow cytometry. Data are mean ± SEM of three independent experiments. (b) Cd38−/− NK cells were inhibited tumor-triggered translocation of perforin and granzyme B towards immunological synapses. Cd38+/+ or Cd38−/− NK cells were stimulated with B16F10 cells at 1:1 ratio at 37°C for 20 min, and then stained with perforin or granzyme B. The dashed line indicates the immunological synapse. (Scale bar, 5 μm). All images were representative of at least three independent experiments. (c) Degranulation of Cd38+/+ or Cd38−/− NK cells upon stimulation with B16F10 cells for 2 h at 37°C. Shown is a representative of three independent experiments. (d and e) Ca2+ signals in Cd38+/+ or Cd38−/− NK cells upon stimulation with B16F10 cells. NK cells were loaded with Fluo-4 AM for 40 min at 37°C and Ca2+ levels in NK cells were measured following treatment with B16F10 cells labeled with cell tracker orange CMRA (red). Arrow indicates the time of addition of B16F10 cells. (Scale bars, 10 μm). Shown is a representative of three independent experiments.

Ghosh, G. et al. Hypoxia-induced microRNA-424 expression in human endothelial cells regulates HIF-alpha isoforms and promotes angiogenesis. J. Clin. Invest. 120, 4141–4154 (2010).

        We are developing our lead product candidate, zilucoplan (formerly RA101495 SC), a potent, synthetic, macrocyclic peptide C5 inhibitor, formulated for convenient, self-administered, subcutaneous, or SC, injection, which is an injection into the tissue under the skin, for the treatment of various complement-mediated diseases, including generalized myasthenia gravis, or gMG, paroxysmal nocturnal hemoglobinuria, or PNH, and other complement-mediated disorders.

Pursuant to our Articles, if at any time the share capital is divided into different classes of shares, the Company may by shareholder resolution, unless otherwise provided by the terms of issue of the shares of that class, modify, convert, broaden, add or otherwise alter the rights, privileges, advantages, restrictions and provisions related or unrelated at that time to the shares of any class with the sanction of a resolution passed by a simple majority of those present, personally or by proxy, and voting thereon at a separate general meeting of the holders of the shares of that class. Such majority approval is consistent with Israeli law.