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Our Board has resolved to delegate to the audit committee the power to pre-approve non-auditing services rendered by the Company’s independent auditors without the need for further approval by our Board. As such, on March 10, 2019, our audit committee approved the adoption of a pre-approval policy, such that the Chairman of the audit committee is authorized to pre-approve any engagement of our independent auditors during a period of twelve months from the date of such approval, for the provision of non-auditing services, for fees not to exceed $20,000, and any such engagement which exceeds $20,000 shall require a pre-approval by the entire audit committee. Once services have been pre-approved, our management must then report to the audit committee on a periodic basis regarding the extent of services actually provided in accordance with the pre-approval policy, and regarding the fees for the services performed. Such fees for 2017 were pre-approved by the audit committee in accordance with the pre-approval policy.

Liao, F. Herbs of activating blood circulation to remove blood stasis. Clin Hemorheol Microcirc. 23, 127–131 (2000).

Brainstorm Cell Therapeutics Inc. (OTCBB: BCLI ) Brainstorm Cell Therapeutics Inc. is an emerging company developing adult stem cell therapeutic products, derived from autologous (self) bone marrow cells, for the treatment of neurodegenerative diseases. The NurOwn™ patent pending technology is based on discoveries made by the scientific team led by prominent neurologist Professor Eldad Melamed, Head of Neurology at Rabin Medical Center, and expert cell biologist Dr. Daniel Offen, Head of the Neuroscience Laboratory at the Felsenstein Medical Research Center of Tel-Aviv University. The technology allows for the differentiation of bone marrow-derived stem cells into functional neurons and astrocytes, as demonstrated in animal models. The Company holds rights to develop and commercialize the technology through an exclusive, worldwide licensing agreement with Ramot at Tel Aviv University Ltd., the technology transfer company of Tel-Aviv University. The Company’s initial focus is on Parkinson ALS and Spinal Cord Injury, although its technology has promise for treating several other diseases including MS, Huntington’s disease and stroke.

This is blog. It is expected people say any crazy stuff they want to. I was referring to “leaders” who get widely quoted by media.

GenSpera, Inc. (OTCBB:GNSZ) is a development stage oncology company focused on therapeutics that deliver a potent, unique and patented drug directly to tumors. GenSpera’s technology platform combines a potent, plant-derived cytotoxin (thapsigargin) with a prodrug delivery system that releases the drug only within the tumor. Unlike standard cancer drugs, thapsigargin kills cells independent of their division rate, thus making it effective at killing all fast- and slow-growing cancers and cancer stem cells. GenSpera’s prodrug platform is the subject of seven issued patents with four additional patents pending. In early 2010, GenSpera initiated a Phase I clinical trial targeting solid tumor cancers with its lead drug, G-202, at Johns Hopkins University and the University of Wisconsin. The Company anticipates completion of Phase I trials in Q2 2011. Upon successful completion of its Phase I trial, GenSpera expects to initiate multiple Phase II trials for G-202 in several different types of cancer. The company’s second drug, G-115, will directly target prostate cancer. The Company anticipates filing an application to commence Phase I trials of G-115 in Q3 2011. GenSpera is also developing a cancer imaging platform, derived from thapsigargin, the active ingredient in its therapeutic drugs, coupled with its patented tumor-targeted delivery system.

Blasco uses a viral delivery to express HTERT within cells for a transient effect extending telomeres. It is not integrated within the genome so it does not become permanent. CRISPR would no doubt make a permanent change, which we probably wouldn’t want.

Mark Aldebaran well concluded. By the way Mark this is one of the key focus of my Lab, if you remember, to upreguate the degraded repair systems back to maintain homeostasis so in a way I am glad I am attacking the very backbone of their theorem that inversely leads to inevitable loss of life but the damage and repair interplay at this time juncture seems so alarmingly complex. But 8 too am an optimist and agree with both of you that we humans have the capacity to find the technology sometime in the future.

If we receive marketing approval for Aramchol, sales will be limited unless the product achieves broad market acceptance.

Beck, A., Kolisek, M., Bagley, L. A., Fleig, A. & Penner, R. Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. FASEB. J. 20, 962–964 (2006).

Well the FDA has started to approve gene therapies now, although only for specific maladies, not aging itself, which might be a bit of a leap for them. That another reason why Michael Fossel is going the FDA route with this therapy for Alzheimer’s. Liz is going the other way, off shore – less credible, but faster and cheaper. It will be interesting to see which approach will be more successful. If Liz gets some success with undeniable results (like an obviously rejuvenated person according to many biomarkers), then the game will change and it might even be curtains for the FDA.

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