Tu, L. et al. Astragaloside IV protects heart from ischemia and reperfusion injury via energy regulation mechanisms. Microcirculation 20, 736–747, 10.1111/micc.12074 (2013).

Cash equivalents are short-term, highly liquid investments that are readily convertible into cash with maturities of three months or less as of the date acquired.

Even if we, or any future collaborators, are able to commercialize any product candidate that we, or they, develop, the product may become subject to unfavorable pricing regulations or third-party payor coverage and reimbursement policies, any of which could harm our business.

Compugen Ltd. (NasdaqGM: CGEN ) Compugen is a leading drug and diagnostic product candidate discovery company. Unlike traditional high throughput trial and error experimental based discovery, Compugen’s discovery efforts are based on in-silico (by computer) prediction and selection utilizing a growing number of field focused proprietary discovery platforms accurately modeling biological processes at the molecular level. The resulting product candidates are then validated through in vitro and in vivo experimental studies and out-licensed for further development and commercialization under various forms of revenue sharing agreements. Compugen’s current collaborations include Biosite, Medarex, Inc., Merck & Co., Inc., Ortho-Clinical Diagnostics (a Johnson & Johnson company), Roche, Siemens Healthcare Diagnostics, Inc., and Teva Pharmaceutical Industries.

It’s certainly a complicated picture. Here we learn that MTOR inhibition (or AMPK activation) is actually preserving telomeres by unregulating the shelterin protein TERRA.

Our U.S. shareholders may suffer adverse tax consequences due to our classification as a passive foreign investment company).

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(a) Representative tracings showed the vasorelaxant effects of β-BA (200 mg/kg/d) in phenylephrine pre-contracted aortic rings. β-BA induced relaxation could be significantly attenuated when the endothelium intact specimens were exposed to L-NAME (10−4 M). The values of results are expressed as Means ± SD (n = 8). Experimental groups: control (■), model (⧫), model + β-BA 200 mg/kg (▲), model + β-BA 200 mg/kg + L-NAME (○). ##p < 0.01 versus the control group, #p < 0.05 versus the control group, **p < 0.01 versus the model group, *p < 0.05 versus the model group. (b) si-con and si-eNOS were transfected to HUEVCs for 12 h, then the cells were pretreated with β-BA for 24 h before being subjected to 6 h OGD then incubated with β-BA for an additional 24 h. Expression of eNOS was determined. Cell viability was measured with MTT assay. The data represent the results of (Mean ± SD) of triplicate independent experiments. ##p < 0.01 versus the control group, **p < 0.01 versus OGD group, p < 0.01 versus β-BA group.

        The information required by this item will be contained in the Proxy Statement and is incorporated in this Annual Report on Form 10-K by reference.

I’ve read a couple of a papers that suggest you can improve on OSKM quite considerably by including some extra factors. According to this paper: ‘Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation’, you can improve the efficiency of reprogramming by 100 times using either p53 siRNA or UTF1. Now I know you don’t want to go all the way back to pluripotency, but this might still be useful.

From time to time, legislation is drafted, introduced and passed in governmental bodies that could significantly change the statutory provisions governing the approval, manufacturing and marketing of products regulated by the FDA or EMA and other applicable regulatory bodies to which we are subject. In addition, regulations and guidance are often revised or reinterpreted by the national agency in ways that may significantly affect our business and our therapeutic candidates. It is impossible to predict whether such legislative changes will be enacted, whether FDA or EMA regulations, guidance or interpretations will change, or what the impact of such changes, if any, may be. We may need to adapt our business and therapeutic candidates and products to changes that occur in the future.

Mark, My Lab is awaiting committee approval to launch a double blind placebo trial with GHK on rats. We are including a very comprehensive list of assays to thoroughly investigate its efficacy besides safety and dosage. If successful we will apply for human clinical trial next year. This is what I have in my notes on Honokiol and Magnolia derived from studies: Honokiol is known to induce an antianxiety effect and magnolol is considered to be an antidepressant. Research has clearly shown that honokiol is able to stimulate the release of acetylcholine and inhibit the action of acetylcholinesterase Various observations have revealed the protective role of the honokiol molecule vis-a-vis the mitochondria in the cells of the brain, liver and heart. Honokiol protects these vital organs from the harmful effects of free radicals. In its role as a powerful antioxidant, honokiol has a unique capacity to prevent the peroxidation of lipids, a primary risk factor for cardiovascular disease.  Finally, another important virtue of honokiol is its ability to normalize blood glucose levels. It has been convincingly shown that the honokiol molecule can reduce blood sugar levels and prevent weight gain in diabetic mice. This is due to its agonist action vis-à-vis the gamma PPAR (peroxisome proliferator-activated receptor), which are proteins of the nuclear receptor group, liaison, lipids and transcription of target genes involved in adipogenesis and metabolism. As an agonist, honokiol mimics the action of these PPAR and has a similar physiological action that can limit the production of adipose tissue and fat accumulation in adipocytes. The use of an extract of Magnolia as a complement to food should not cause any health related side effects if the prescribed doses and treatment instructions are strictly observed. The recommended daily dose is between 30 and 90 mg per day. It is recommended that extract of Magnolia capsules be taken at mealtime. Purchasing a standardized Magnolia extract with a purity rating of more than 90% is the best way to maximize the benefits of honokiol. Combination of honokiol with the mTOR inhibitor rapamycin presents synergistic effects on induction of apoptosis of cancer cells.