Our general and administrative expenses amounted to approximately $4.4 million for the year ended December 31, 2018, representing an increase of approximately $0.6 million, or 16%, compared to approximately $3.8 million for the year ended December 31, 2017. The increase primarily resulted from an increase in non-cash stock based compensation expenses of approximately $0.4 million as well as an increase in professional services expenses of approximately $0.3 million. We expect that general and administrative expenses will increase through 2019 and beyond.

It would be interesting to get the picture like “LC/MS could have detected 1e-6 mole fraction of an impurity, but the FDA standard requires 1e-8 for this.”

This meta-analysis has several limitations. Most importantly, the eligible RCTs usually had small populations and short follow-up (up to 6 months in 8/9 included studies). The included studies were also heterogeneous with regards to population characteristics (there were patients with hyperlipidemia, renal failure or atrial fibrillation), study design, and statin preparation and dose. In order to cover these variabilities we used a more conservative random-effects model and performed the sensitivity analysis. The meta-regression analysis also revealed that none of the moderator parameters i.e. statin dose, duration of statin therapy and baseline ADMA concentrations were significantly associated with the pooled estimate of statin effect on plasma ADMA concentrations. Finally, the smoking status, an important determinant of ADMA levels (as well as other variables, such as: hyperhomocysteinemia, hypertension, coronary artery disease, heart failure, and administration of the following drugs: antioxidants, estrogen, vitamin A, angiotensin converting enzyme inhibitors, angiotensin AT1 receptor antagonists, and beta-adrenoreceptor blocking drugs), could not be considered in this meta-analysis due to lack of data.

We may be forced to abandon development of Aramchol, or any future product candidates, which would have a material adverse effect on our business and may force us to cease operations.

I found a stable supplier of Sulforaphane their product is called prostaphane and is made by a french company.

        Research and development expenses consist primarily of costs incurred for our research activities, including development of our proprietary chemistry technology platform, and our pre-clinical and clinical candidates, which include:

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Expressions of osteogenic markers (Runx-2, ALP, OCN, and BSP) of BMSCs cultured in the presence and absence of the NOS inhibitor or siRNA-iNOS transfection in the cell culture medium for 3 days are measured by real time PCR relative to GAPDH expression and normalized to the expressions on Blank without the NOS inhibitor and siRNA. (a) eNOS inhibitor (L-NAME). (b) nNOS inhibitor (Sper). (c) iNOS inhibitor (L-Can). (d) siRNA-iNOS transfection. The bottom left illustrates transfection of siRNA-iNOS with GFP gene into BMSCs and microscopic images of the cells before and after siRNA transfection. (*) and (**) denote two statistical significance (p < 0.05 and p < 0.01), respectively, compared to the sample without NOS inhibitors and siRNA.

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yes you are correct Paul, i just used lactic acid as an example. I should have used the homocysteine/b12 deficiency instead, which is in fact a real issue.

These new chemical entities (NCEs) must be produced and analyzed in accordance with the rules of GMP. Bachem offers its peptide custom manufacturing and the related services from the early preclinical phase onwards. Bachem offers them at such an early stage so that an optimal basis can be created for a reliable partnership with the customer right up to market approval and beyond. This business segment accounts for 50% of Bachem’s sales revenue.

Yes IGF-1 is an interesting one. I expect it reduces as a protection against aging by slowing everything down, though this is me speculating again.