We rely on third parties, such as contract research organizations, medical institutions, clinical investigators and contract laboratories to oversee most of the operations of our clinical trials and to perform data collection and analysis. As a result, we may face additional delays outside of our control if these parties do not perform their obligations in a timely fashion or in accordance with regulatory requirements. If these third parties do not successfully carry out their contractual duties or obligations and meet expected deadlines, if they need to be replaced, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical protocols or for other reasons, our financial results and the commercial prospects for Aramchol or any other potential product candidates could be harmed, our costs could increase and our ability to obtain regulatory approval and commence product sales could be delayed.

Because we do not intend to declare cash dividends on our ordinary shares in the foreseeable future, shareholders must rely on appreciation of the value of our ordinary shares for any return on their investment.

        Our success depends, and will likely continue to depend, upon our ability to hire, retain the services of our current executive officers, directors, principal consultants and others. In addition, we have established relationships with universities and research institutions which have historically provided, and continue to provide, us with access to research laboratories, clinical trials, facilities and patients. Our ability to compete in the biotechnology and pharmaceuticals industries depends upon our ability to attract and retain highly qualified managerial, scientific and medical personnel.

In the end, it will be crucial to get all these different stakeholders together to discuss issues and to see the bigger picture. At this point, Fuglsang says, “that may be wishful thinking.”

Endothelium plays a predominant role in maintaining vascular homeostasis by means of modulation9. It has been demonstrated that blood stasis syndrome is closely related to hemorheological disorder, platelet dysfunction, vascular endothelium injury, microcirculation disturbance, inflammation and immunological regulation10. Endothelium is responsible for the maintenance of vascular homeostasis, thereby contributes to regulating vascular tone and thrombosis and also the proliferation and migration of smoothing muscle cell11,12. This balance may be disturbed and the endothelial cells are often damaged when disease arises, which could result in dysfunction and abnormal secretion of active substances (e.g. NO, NOS, ET-1, and prostacyclin PGI2)13.

Yeagle, P. L. The biophysics and cell biology of cholesterol: An hypothesis for the essential role of cholesterol in mammalian cells. in Cholesterol in Membrane Models (ed. Finegold, L. ) 1–10 (CRC Press, Boca Raton, 1993).

Cash equivalents are short-term, highly liquid investments that are readily convertible into cash with maturities of three months or less as of the date acquired.

Changes in regulatory requirements or guidance or unanticipated events during our clinical trials may result in the need for us to amend clinical trial protocols. Amendments may require review and approval by regulators and/or IRBs, and re-consent subjects, which may adversely affect the cost, timing or successful completion of a clinical trial. If we experience delays in the completion of, or if we terminate, any of our clinical trials, the commercial prospects for Aramchol would be harmed and our ability to generate product revenue would be delayed, possibly materially.

Natural processes are all irreversible processes. So the aging couldn’t be reversed it could only be slowed with all the consequences. For example, If the aging could be slowed 10 times then, the humans could live 1000 years but also the activity of the brain will be slowed accordingly so 10 years will be perceived (in average ) as 1 year.

BelAiba, R. S. et al. Redox-sensitive regulation of the HIF pathway under non-hypoxic conditions in pulmonary artery smooth muscle cells. Biol. Chem. 385, 249–257 (2004).

So you really don’t want to live over 70? That is crazy! Alan is over 70 and is fit and healthy. My own father is 77 and doing well. You are saying you want to live a shorter than average life expectancy. Now I would understand if you were to say living longer than 70 is conditional on you being in good health, but since you are here reading this blog, you must know that is a pretty good bet.

CD38 is a multifunctional enzyme that catalyzes the synthesis of Ca2+-mobilizing second messengers, cADPR and NAADP, from β-nicotinamide adenine dinucleotide (β-NAD+) and its phosphate form (β-NADP+), respectively22,23,24. NAADP and cADPR are further converted to ADP-ribose 2′-phosphate and ADPR, respectively22,23,25. CD38 has long been known to trigger cytotoxic responses and release granzymes in activated NK cells26, but the precise mechanisms by which CD38 mediates cytolytic activity have remained obscure. Interleukin 2 (IL-2)-activated NK cells are more lytic to target cells than resting NK cells, suggesting that IL-2 induces the de novo expression of proteins that act between CD38 and the lytic machinery in NK cells27.