This annual report does not include an attestation report of our independent registered public accounting firm regarding internal controls over financial reporting because the JOBS Act provides us with an exemption from that requirement, as we qualify as an emerging growth company.

Tran, C. T., Leiper, J. M. & Vallance, P. The DDAH/ADMA/NOS pathway. Atherosclerosis. Supplements 4, 33–40 (2003).

Ushio-Fukai, M. et al. Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling. J Biol Chem 276, 48269–75 (2001).

In terms of your suggestions Paul, I’m afraid we can’t separate intermittent fasting benefits from CR, and IGF is too intertwined with MTOR for us to be confident benefits would be additive. I regard angiotensin treatment as mainly benefiting mitochondria. So it probably wouldn’t sum if you’re already doing NR or something like that.

Hi Mark, Comment about TERRA and mTOR inhibition preserving telemeres very interesting. Clear from Ellizabeth Blackburn that lifestyle to preserve telemeres and lifestyle to lower mTOR huge overlap. Also being energy deficit is beneficial as lowers mTOR pathway.

The requirements associated with being a public company require significant company resources and management attention.

“So we arrive at the million-dollar question: Are regulatory agencies and pharmacopeias doing a good enough job, if a sponsor can comply with [most] regulations and yet send a product on the market which contains carcinogens,” asks Anders Fuglsang, founder of Fuglsang Pharma. “We can’t test for everything, but I’m not entirely happy with that statement as a patient or consumer,” he says. Fuglsang hopes that there will be an independent analysis of the root cause of the nitrosamine contamination, performed by independent experts outside of regulatory agencies or pharmacopeias. In the end, he says, “we can only find what we are looking for.” But the sartan API contamination case suggests a need to focus more closely on assessing potential risks during process synthesis review.

Hypoxia-sensing via HIF-1 upregulates the transcription of miR-322, which then exerts positive feedback by facilitating stabilization of HIF-1α by targeting the molecules involved in its degradation for ubiquitination and degradation23. Dysregulation of BMP signaling by increased miR-322 promotes the proliferation and migration of PASMCs.

All the super positive info about telemerase comes from people in business of selling stock in their telemetry companies. One big infomercial.

Backup withholding is not an additional tax. Amounts withheld as backup withholding from a payment may be credited against a U.S. Holder’s U.S. federal income tax liability and such U.S. Holder may obtain a refund of any excess amounts withheld by filing the appropriate claim for refund with the IRS and furnishing any required information in a timely manner.

General and administrative expenses consist primarily of compensation for employees in executive and operational roles, including finance/accounting, legal and other operating positions in connection with our activities. Our other significant general and administrative expenses include non-cash stock-based compensation costs and facilities costs (including the rental expense for our offices in Tel Aviv, Israel), professional fees for outside accounting and legal services, travel costs, investors relations, insurance premiums and depreciation.

Lopez, L. C. et al. Plasma-treated nitrogen-containing surfaces for cell adhesion: the role of the polymeric substrate. Plasma Process. Polym. 4, S402–S405 (2007).