The yield of synthesis is not great, André says, so it is difficult to predict whether a residue of unreacted epichlorohydrin might be carried over in the final product. Nevertheless, he asks, “Which impurities does the US Pharmacopoeia require testing for? Chlorides, sulfates, sodium and potassium, none of which is toxic at such levels.” He wonders how many manufacturers of this compound are even aware of the potential risk.

Goch, A., Banach, M., Mikhailidis, D. P., Rysz, J. & Goch, J. H. Endothelial dysfunction in patients with noncomplicated and complicated hypertension. Clinical and experimental hypertension 31, 20–30, doi: 10.1080/10641960802409846 (2009).

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Our financial income, net, for the year ended December 31, 2017 was approximately $0.06 million, representing an increase of approximately $0.03 million, or approximately 86%, compared to approximately $0.035 million for the year ended December 31, 2016.

Yes to all, we could list so many, the work of Luther Burbank fascinates me still. And to clarify, I did not mean to point out Einstein’s humanness, as all great scientists will take a blind path at some point. I was only was using it as an example to refer back to the post about never revisiting the idea of God because there is nothing “factual”. Do we know what we think we know? It quickly become philosophical as I think Paul mentioned.

The salicin in White willow bark extracts is supposed to be gentler on the stomach than acetylsalicylic acid.

In the event of grantee’s termination prior to a vesting date by reason of such grantee’s death or disability, all of such grantee’s RSUs shall immediately become vested as of the date of such termination. In the event of a grantee’s termination for cause prior to settlement, all of such grantee’s RSUs shall immediately be forfeited for no consideration as of the date of such termination. If a grantee’s employment or service is terminated for any other reason, (1) all vesting with respect to such grantee’s RSUs shall cease, (2) all of such grantee’s unvested RSUs shall immediately be forfeited for no consideration as of the date of such termination, and (3) to the extent not already settled, all of such grantee’s vested RSUs shall be settled in accordance with the settlement schedule set forth in the applicable award agreement.

All forward-looking statements attributable to us or persons acting on our behalf speak only as of the date hereof and are expressly qualified in their entirety by the cautionary statements included in this annual report. We undertake no obligations to update or revise forward-looking statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipated events. In evaluating forward-looking statements, you should consider these risks and uncertainties.

We may be required to initiate litigation to enforce our rights or defend our activities in response to alleged infringement of a third-party. In addition, we may be sued by others who hold intellectual property rights and who claim that their rights are infringed by Aramchol or any of our future products or product candidates. These lawsuits can be very time consuming and costly. There is a substantial amount of litigation involving patent and other intellectual property rights in the biotechnology and pharmaceutical industries generally.

It is very difficult, but it is sometimes possible to protect yourself but still alert third parties to some problems. The WSJ exposed problems at Theranos (Dx, not Tx). Some legislators can be contacted.

I know your 99.999% / 0.001% was probably rhetorical, but is that level (five 9s) in the ballpark of what can actually be assured without knowing the identity of an impurity?

Wang, Y. et al. QSYQ Attenuates Oxidative Stress and Apoptosis Induced Heart Remodeling Rats through Different Subtypes of NADPH-Oxidase. Evid Based Complement Alternat Med 2013, 824960, 10.1155/2013/824960 (2013).