The Companies Law further stipulates that directors who are not qualified to serve on the audit committee, as described above, may not serve on the remuneration committee either and that similar to the audit committee, generally, any person who is not entitled to be a member of the remuneration committee may not attend the remuneration committee’s meetings. Our Board has adopted a remuneration committee charter setting forth the responsibilities of our remuneration committee, as described below.

If a special tender offer was accepted by a majority of the shareholders who announced their stand on such offer, then shareholders who did not respond to the special offer or had objected to the special tender offer may accept the offer within four days of the last day set for the acceptance of the offer. In the event that a special tender offer is accepted, then the purchaser or any person or entity controlling it and any corporation controlled by them shall refrain from making a subsequent tender offer for the purchase of shares of the target company and may not execute a merger with the target company for a period of one year from the date of the offer, unless the purchaser or such person or entity undertook to effect such an offer or merger in the initial special tender offer.

to their first dose due to an unrelated hospitalization, resulting in a total of 42/44 (95%) subjects receiving doses in the extension study. The diagram below summarizes the Phase 2 trial design:

Deferred-tax assets for carry forward losses in Malta and Israel are calculated using the applicable tax rate at the time of expected realization of the carry forward losses. The Company has provided full valuation allowances in respect of deferred-tax assets. Management currently believes that it is more likely than not that those deferred taxes will not be realized in the foreseeable future.

In the early 1980s, localized drug delivery was another novel concept pursued with PLG polymers. One program, funded by the US Army Institute of Dental Research, focused on the local delivery of antibiotics to treat battle wounds (12). The concept was for a soldier to apply a powder of controlled-release PLG/antibiotic microparticles directly into a wound. The microparticles would then slowly release the antibiotic and maintain a high level of drug at the wound site for 14 or 21 days to achieve efficacy without requiring daily, oral dosing.

Antoniades, C. et al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. European heart journal 30, 1142-1150 , doi: 10.1093/eurheartj/ehp061 (2009).

In addition, a shareholder also has a general duty to refrain from discriminating against other shareholders.

So Josh, as if right on cue with your post , this study of aspirin and cancer came out today from the Chinese University of Hong Kong, Kelvin Tsoi presented it at the United European Gastrenterology meeting in Barcelona. They looked at 600,000 people over 10 years. Of these, 206,295 were ASA users. Average age 67.5 years, median dose 80mg and average duration 7.7 years. The team followed outcomes for up to 14 years looking for cancer incidences. About 16% developed cancer, withlung being the most prevalent. So here it is, the ASA users were: 47% less likely to have liver and esophageal cancer 38% less likely to have stomach cancer 34% less likely pancreatic cancer 24% less colon Also significant reduction in leukemia, lung and prostate cancers Wow

        The patent positions of pharmaceutical, biotechnology and other life sciences companies can be highly uncertain and involve complex legal and factual questions for which important legal principles remain unresolved. Changes in either the patent laws or in interpretations of patent laws in the U.S. and other countries may diminish the value of our intellectual property. Further, the determination that a patent application or patent claim meets all of the requirements for patentability is a subjective determination based on the application of law and jurisprudence. The ultimate determination by the USPTO or by a court or other trier of fact in the U.S., or corresponding foreign national patent offices or courts, on whether a claim meets all requirements of patentability cannot be assured. For example, our lead C5 inhibitor portfolio consists of six families of patent applications that we own directed to our lead C5 inhibitor and related methods of use. Although we have conducted searches for third-party publications, patents and other information that may affect the patentability of claims in our various patent applications and patents, we cannot be certain that all relevant information has been identified. Accordingly, we cannot predict the breadth of claims that may be allowed or enforced in our patents or patent applications, in our licensed patents or patent applications or in third-party patents.

        In addition, the distribution of prescription pharmaceutical products is subject to the Prescription Drug Marketing Act, or the PDMA, which regulates the distribution of drugs and drug samples at the federal level, and sets minimum standards for the registration and regulation of drug distributors by the states. Both the PDMA and state laws limit the distribution of prescription pharmaceutical product samples and impose requirements to ensure accountability in distribution.

        Valuation methodologies used for assets measured or disclosed at fair value are as follows:

All forward-looking statements attributable to us or persons acting on our behalf speak only as of the date hereof and are expressly qualified in their entirety by the cautionary statements included in this annual report. We undertake no obligations to update or revise forward-looking statements to reflect events or circumstances that arise after the date made or to reflect the occurrence of unanticipated events. In evaluating forward-looking statements, you should consider these risks and uncertainties.