Hi Mark, I agree with you. Approach 100% different. I consider treatment of AD when have dementia plaques and tangles impossible. If you think might work, I’ll give you 5:1 odds on a friendly 1 million dollar bet. However, apoe4 carriers have changes in PET scan 50 years before onset dementia at mean age 75. And those people can be treated before onset of disease. If works in E4 nice and more likely than not work in human carriers ApoE4. That treatment for apoe4 carrier will be available very soon.

        The valuation allowance increased by $19.3 million during the year ended December 31, 2018, primarily due to an increase in net operating losses as a result of increased capitalized research and development costs, research and development credits and stock-based compensation expense. The valuation allowance increased by $8.2 million during the year ended December 31, 2017, primarily due to an increase in capitalized research and development costs, research and development credits and

Antoniades, C. et al. Role of asymmetrical dimethylarginine in inflammation-induced endothelial dysfunction in human atherosclerosis. Hypertension 58, 93–98, doi: 10.1161/HYPERTENSIONAHA.110.168245 (2011).

Well the EDQM has now added their word to the debate of contaminantshttps://www.edqm.eu/en/news/update-edqm-review-cep-applications-sartan-substances-4-february-2019

Looking at Blackburn 2017 book; no commercial endorsements. In regard section on testing she lists no companies and adds as caveat unregulated business. Didn’t find her name linked to any commercial enterprise. Everything in book to maintain telomeres is free. So looks to me like unlike very many others, Blackburn retains her scientist standing and is a very credible expert.

Stanger, O. & Weger, M. Interactions of homocysteine, nitric oxide, folate and radicals in the progressively damaged endothelium. Clin Chem Lab Med. 41, 1444–1454 (2003).

        We are developing specific inhibitors of Factor D, a critical component of the alternative pathway of complement, as targeted drug candidates for C3GN. By blocking the alternative pathway upstream of C3, we believe that this mechanism may prevent C3 deposition and subsequent renal injury.

Lopez-Sepulveda, R. et al. Wine Polyphenols Improve Endothelial Function in Large Vessels of Female Spontaneously Hypertensive Rats. Hypertension. 51, 1088–1095 (2008).

市场数据：激素治疗常见于乳腺癌和前列腺癌的治疗。2008年乳腺癌的激素治疗市场为50亿美元，占全球激素治疗市场的55.6%。畅销产品有Zoladex, Arimidex, Aromasin, Femara和 tomoxifen。全球老龄化人口是市场增长的推手。

We do not anticipate paying any cash dividends on our capital stock in the foreseeable future. Accordingly, stockholders must rely on capital appreciation, if any, for any return on their investment.

Lipoprotein-deficient serum (LPDS) was prepared following the protocol of Renaud et al.31 with slight variation. Briefly, FBS was adjusted to a density of 1.215 g/mL by adding KBr. After overlaying the FBS with a KBr solution at the same density, the mixture was centrifuged for 65 h at 235,500 g at 4 °C. The floating lipoproteins were removed and the remaining serum was dialysed against 6 changes of 4L Phosphate-buffer saline (PBS) pH 7.4 at 4 °C.

ABBOTT LABORATORIES (NYSE: ABT ) is a global, broad-based health care company devoted to the discovery, development, manufacture and marketing of pharmaceuticals and medical products, including nutritionals, devices and diagnostics. The company employs nearly 90,000 people and markets its products in more than 130 countries.