We had negative cash flow from operating activities of approximately $12.1 million for the year ended December 31, 2017 as compared to a negative cash flow from operating activities of approximately $12.1 million for the year ended December 31, 2016. The negative cash flow from operating activities for the year ended December 31, 2017 was mainly attributable to our net loss of approximately $12.3 million.

The following is a summary description of the material terms of those transactions with related parties to which we, or our subsidiaries, are party and which were in effect since January 1, 2018.

Nanayakkara, P. W. et al. Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD. American journal of kidney diseases : the official journal of the National Kidney Foundation 53, 41–50, doi:10.1053/j.ajkd.2008.06.016 (2009).

External directors are elected for a term of three years at the general meeting of shareholders by a simple majority, provided that the majority includes either:

        The following table provides stock-based compensation by the financial statement line item in which it is presented:

Paliwal, S., Shi, J., Dhru, U., Zhou, Y. & Schuger, L. P311 binds to the latency associated protein and downregulates the expression of TGF-beta1 and TGF-beta2. Biochemical and biophysical research communications. 315, 1104–1109 (2004).

The regulations promulgated under the Companies Law define an external director with requisite professional qualifications as a director who satisfies one of the following requirements: (1) the director holds an academic degree in either economics, business administration, accounting, law or public administration, (2) the director either holds an academic degree in any other field or has completed another form of higher education in the company’s primary field of business or in an area which is relevant to his or her office as an external director in the company, or (3) the director has at least five years of experience serving in any one of the following capacities, or at least five years of cumulative experience serving in two or more of the following capacities: (a) a senior business management position in a company with a substantial scope of business, (b) a senior position in the company’s primary field of business or (c) a senior position in public administration.

BELLUS Health, Inc. (TSX:BLU.TO ) is developing drugs for rare diseases with a particular focus on renal disorders. The Company’s lead program is KIACTA™, a novel drug candidate currently in a Phase III Confirmatory Study for the treatment of AA amyloidosis, an orphan indication resulting in renal dysfunction that often rapidly leads to dialysis and death. KIACTA™ is partnered with global private equity firm Auven Therapeutics.

SODM, RhoGDI1 and HSPB1, the three proteins related to oxidative stress, were assessed by western blot. As a major endogenous antioxidant, SODM obviously reduced in AAS groups compared to Sham. This down-regulation was protected significantly by all the treatments except DO and ASIV+DO with QSYQ and ASIV+DLA+R1 being most effective (Fig. 7a,b). In contrast, the expression of RhoGDI1 increased significantly in AAS groups. Again, QSYQ was the most effective treatment for restoration of RhoGDI1. Interestingly, DLA, R1 and the combinations containing DLA and/or R1 relieved the expression of RhoGDI1, whereas ASIV, DO and ASIV+DO did not show any significant effect (Fig. 7a,c). AAS challenge remarkably increased HSPB1, and all treatments except DO alleviated the expression of HSPB1 (Fig. 7a,d). In addition, as shown in Fig. 7e, the content of methane dicarboxylic aldehyde (MDA) increased significantly in AAS1M compared to sham group, and further increased in AAS2M, while QSYQ, DLA and the combinations containing DLA attenuated MDA content. Of notice, ASIV and R1 alone did not show any effect on MDA, whereas ASIV+R1 obviously reduced the MDA level. Among these effective drug treatments, QSYQ again was the most effective one.

During the extended period, the scope of protection is limited to "any use approved for the product" if the patent claims a product, and to "any use claimed by the patent and approved for the product" if the patent claims a method of using a product.[x] In Merck & Co., Inc. v. Kessler (1996), the Federal Circuit indicated that "the restoration period of the patent does not extend to all products protected by the patent but only to the product on which the extension was based."[xi]

I am not sure if telomere elongation on its own can rescue senescence cells, although it has been done in progeria afflicted cells. I suspect it can. Perhaps also a rejuvenated immune system would increase the natural clearance post treatment. And if this is not sufficient perhaps a synergistic pairing would be senolytic clearance followed by telomerase therapy; as you say this might be necessary anyway as one will need to replace the removed senescent cells.

We rely on third parties, such as contract research organizations, medical institutions, clinical investigators and contract laboratories to oversee most of the operations of our clinical trials and to perform data collection and analysis. As a result, we may face additional delays outside of our control if these parties do not perform their obligations in a timely fashion or in accordance with regulatory requirements. If these third parties do not successfully carry out their contractual duties or obligations and meet expected deadlines, if they need to be replaced, or if the quality or accuracy of the clinical data they obtain is compromised due to the failure to adhere to our clinical protocols or for other reasons, our financial results and the commercial prospects for Aramchol or any other potential product candidates could be harmed, our costs could increase and our ability to obtain regulatory approval and commence product sales could be delayed.