The term of individual patents depends upon the legal term of the patents in the countries in which they are obtained. In most countries in which we file, the patent term is 20 years from the earliest date of filing a non-provisional application which matures into a granted patent. A U.S. patent also may be accorded a patent term adjustment, or PTA, under certain circumstances to compensate for delays in obtaining the patent caused by the U.S. Patent and Trademark Office. In some instances, such a PTA may result in a U.S. patent term extending beyond 20 years from the earliest date of filing a non-provisional patent application. In addition, in the U.S., the term of a U.S. patent that covers an

Kim, S. Z., Kim, S. H., Park, J. K., Koh, G. Y. & Cho, K. W. Presence and biological activity of C-type natriuretic peptide-dependent guanylate cyclase-coupled receptor in the penile corpus cavernosum. J Urol. 159, 1741–1746 (1998).

During 2018, 2017 and 2016, the Company recorded salary expenses, stock based compensation expenses and directors’ fee to its related parties in the amount of $3.7 million, $3.4 million and $2.5 million respectively.

        The Company expenses research and development costs to operations as incurred. The Company defers and capitalizes nonrefundable advance payments made by the Company for research and development activities until the related goods are received or the related services are performed.

Pursuant to the Companies Law, an external director is required to have either financial and accounting expertise or professional qualifications according to criteria set forth in regulations promulgated under the Companies Law, provided that at least one of the external directors has financial and accounting expertise. However, if at least one of our other directors (1) meets the independence requirements of the Exchange Act, (2) meets the Nasdaq requirements for membership on the audit committee and (3) has financial and accounting expertise as defined in the Companies Law and applicable regulations, then neither of our external directors is required to possess financial and accounting expertise as long as both possess other requisite professional qualifications as required under the Companies Law and regulations promulgated thereunder.

As of December 31, 2018, a total of the 1,550,612 outstanding and exercisable options are “in the money” with aggregate intrinsic value of $5.8 million; while as of December 31, 2017 a total of 2,096,714 outstanding and exercisable options were “in the money” with aggregate intrinsic value of $11.4 million.

increase in non-cash stock-based compensation, primarily relating to our annual grants awarded in February 2018; a $1.1 million increase in consulting and professional fees primarily related to pre-commercialization activities; a $0.2 million increase in legal and audit costs; and a $0.6 million net increase in insurance, taxes and other expenses.

The special tender offer may be consummated only if (i) at least 5% of the voting power attached to the company’s outstanding shares will be acquired by the offeror and (ii) the special tender offer is accepted by a majority of the votes of those offerees who gave notice of their position in respect of the offer; in counting the votes of offerees, the votes of a holder of control in the offeror, a person who has personal interest in acceptance of the special tender offer, a holder of at least 25% of the voting rights in the company, or any person acting on their or on the offeror’s behalf, including their relatives or companies under their control, are not taken into account.

On June 12, 2018, we announced top-line, 52-week results from our global Phase 2b ARREST Study, a multicenter, global, randomized, double-blind, placebo controlled dose-ranging study. A total of 247 patients (approximately one third in the US, one third in Latin America and one third in Europe and Israel) with liver biopsy-proven NASH who were overweight or obese and had pre-diabetes or type II diabetes mellitus were randomized. Patients were randomized in a ratio of 2:2:1 (600mg, 400mg and placebo) taking once-daily oral Aramchol (in the Aramchol treatment arms) or a placebo (in the placebo arm). The treatment part of the trial was 12 months in duration and patients completing this phase were observed for a three month follow-up period. While the we did not meet the primary endpoint of the study, results for the two biopsy endpoints, which may currently constitute a primary endpoint for a Phase 3 trial to support an NDA to the FDA, demonstrated the following: (i) significantly more patients treated with Aramchol 600mg vs. placebo achieved NASH resolution without worsening of fibrosis (16.7% vs. 5.0%; p=0.0514); and (ii) a higher proportion of patients showed at least one-point improvement in fibrosis score without worsening of NASH in Aramchol 600mg vs. placebo (29.5% vs. 17.5%; p=0.2110).  At 52 weeks of treatment, Aramchol continued to show a favorable safety and tolerability profile. We are currently focused on preparing for an end of Phase 2b meeting with the FDA to discuss the results of the ARREST Study and a Phase 3/4 ARMOR study protocol, with a view to initiating a Phase 3/4 clinical study of Aramchol in 2019. If the Phase 3/4 trial is initiated and the Phase 3 portion is successful, we intend to submit an NDA to the FDA for the approval of Aramchol for the treatment of NASH in the United States.

Recently I had to go see my idiot doctor( ID) to get an insurance referral for an echocardiogram that I want to check my cardiac ejection fraction. I’m positive that it’s gone up since rapamycin 3 months ago because of the way that I can now take hills.

Our management is responsible for establishing and maintaining adequate internal control over our financial reporting. Internal control over financial reporting is defined in Rule 13a-15(f) or 15d-15(f) promulgated under the Exchange Act as a process designed by, or under the supervision of, the company’s principal executive and principal financial officers and effected by the company’s board of directors, management and other personnel, to provide reasonable assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in accordance with generally accepted accounting principles and includes those policies and procedures that:

Yokota, T., Terai, T., Kobayashi, T., Meguro, T. & Iwaki, M. Cell adhesion to nitrogen-doped DLCs fabricated by plasma-based ion implantation and deposition method using toluene gas. Surf. Coat. Tech. 201, 8048–8051 (2007).