Our research and development expenses amounted to approximately $9.7 million during the year ended December 31, 2017, representing a decrease of approximately $4.6 million, or approximately 32%, compared to approximately $14.3 million for the year ended December 31, 2016. The decrease primarily resulted from a decrease in research and development subcontractor expenses in connection with the ARREST Study of approximately $2.4 million and other studies of an aggregate of approximately $1.0 million. The decrease in the research and development expenses is also as a result of a decrease in drug development related expenses of approximately $1.0 million. 

Mr. Nir, Ms. Yaron-Eldar and Dr. Sidransky are the current members of our audit committee, with Ms. Yaron-Eldar serving as chairperson. Each of our audit committee members are “independent directors” in accordance with the Nasdaq Capital Market corporate governance requirements, as affirmatively determined by our Board, and Ms. Yaron-Eldar and Dr. Sidransky also meet the qualifications for service as “external directors” under the Companies Law and the regulations promulgated thereunder, also as affirmatively determined by our Board and our shareholders. In addition, our Board has affirmatively determined that Ms. Yaron-Eldar also qualifies as an audit committee financial expert pursuant to the applicable SEC rules, and accordingly has the necessary financial sophistication as required by the Nasdaq Capital Market rules, and as a financial and accounting expert under the Companies Law.

I agree they are healthy compared to their compatriots, but I don’t regard them as healthy. I think the mitochondrial membrane pore is the mechanism by which cells carry out apoptosis, at the behest of the mitochondria who dump their innards out into the cell prompting the nucleus to order self destruct. I think those that reach very old age have not only a naturally low MTOR, but probably also a natural resistance to apoptosis. This might mean some get cancer earlier in life, or perhaps they’re protected from cancer too by low MTOR or other mechanisms. I’ve heard that the very old often die of transthretin amyloid build up in the heart. But they also have very few remaining stem cells, according to the analysis of the blood of one, so they might be coming up against replicative senesnce too.

Mine was around 140 last time I checked so it is lower than 200. The hypothesis that ASA is beneficial because of associated blood loss is certainly interesting and merits further investigation. However, I have not been able to find any evidence that ferritin lower than 100 is beneficial. I have only found evidence that ferritin above 200 is detrimental. Do you have more data? I will start on IP6 regardless of ferritin level, as you have rightly pointed out that there is evidence for cancer prevention. Thanks

激素治疗市场以9.8%的复合增速自2004年的63亿美元成长为2008年的91亿美元。 增长主要来自于主导产品Casodex, Zoladex, Aromasin, Femara 和 Arimidex的销售增长。

Aramchol was evaluated in two Phase 1 clinical trials (under a single protocol) to study its safety, tolerability and PK profile in healthy volunteers, in both single and multiple dose administrations. The first Phase 1 clinical trial was an escalating single-dose trial conducted in 17 healthy subjects testing Aramchol doses ranging from 30 mg to 900 mg, performed in one center in Israel. The subsequent Phase 1 clinical trial was a repeated-dose trial conducted over four days in 25 healthy subjects testing repeated daily doses of Aramchol of 30 mg and 300 mg, performed in one center in Israel. The profiles for the groups were similar and the maximal plasma concentration of Aramchol increased with the higher doses. The PK profile demonstrated that Aramchol is suitable at each dose for once-daily administration and there were neither significant adverse events observed in either Phase 1 trial nor any notable changes in biochemical, hematologic, cardiovascular or other safety parameters.

Moosmang, S. et al. Cellular expression and functional characterization of four hyperpolarization-activated pacemaker channels in cardiac and neuronal tissues. Eur J Biochem 268, 1646–52 (2001).

Great job Akshay, you are definitely on the right track in my opinion. Please keep us informed how your work is going.

Aspirin can help to reduce blood-pressure, but this effect only occurs when taken in the eveninghttp://www.docguide.com/administration-time-dependent-effects-aspirin-blood-pressure-untreated-hypertensive-patients By the way, this time-dependent effect of drugs is commonplace and seems to occur basically with all drugs.

Sakai, K., Hashimoto, Y., Baba, S., Nishiura, A. & Matsumoto, N. Effects on bone regeneration when collagen model polypeptides are combined with various sizes of alpha-tricalcium phosphate particles. Dent. Mater. J. 30, 913–922 (2011).

Rats’ carotid aortas were isolated, fixed in formalin (10%), processed for paraffin sectioning (3 mm thick) and stained with hematoxylin-eosin (H&E). The lumen of blood vessels, vascular walls and vascular endothelial cells of the carotid aortas were observed with microscope.

As part of our research and development studies, we have confirmed that several Aramchol salts have improved solubility as compared to the existing form of Aramchol acid. In 2014, we submitted new patent applications to protect such salts. Should we decide to develop the formulations of Aramchol salts, we will need to conduct an appropriate bioequivalence study, or studies, of the biological equivalence of two proprietary preparations of a drug.