Bachem’s range of products is focused on peptide building blocks, natural and unnatural speciality amino acids, peptide fragments, an impressive list of neuropeptides, peptide inhibitors, peptide substrates, and complex organic molecules, as well as resins and linkers for peptide synthesis.

Unsurprisingly, telomere length at birth is inherited from parents, and is assumed to be correlated to lifespan.  Surpringly, a baby’s telomere length is inherited more from the father than from the mother.  More surprisingly, older fathers sire children with longer telomeres (though their own telomeres are, presumably, shorter).

Calvani, M., Reda, E. & Arrigoni-Martelli, E. Regulation by carnitine of myocardial fatty acid and carbohydrate metabolism under normal and pathological conditions. Basic Res. Cardiol. 95, 75–83 (2000).

        Competition that our products may face from generic versions of our products could negatively impact our future revenue, profitability and cash flows and substantially limit our ability to obtain a return on our investments in those product candidates.

        Our future funding requirements, both short-term and long-term, will depend on many factors, including:

        Subject to the limitations described below, as of December 31, 2018 and 2017, the Company had federal net operating loss carryforwards of $73.3 million and $55.7 million, respectively, to offset future federal taxable income, which will begin to expire in 2028 and will continue to expire through 2037. The 2018 federal net operating loss of $17.6 million has an indefinite life. As of December 31, 2018 and 2017, the Company had state net operating loss carryforwards of $70.2 million and $51.2 million, respectively, to offset future state taxable income, which will begin to expire in 2031 and will continue to expire through 2038. As of both December 31, 2018 and 2017, the Company has trade net operating loss carryforwards of less than $0.1 million at its German subsidiary. There is no expiration of the German net operating loss carryforwards.

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Generally, stock will be considered marketable stock if it is “regularly traded” on a “qualified exchange” within the meaning of applicable Treasury Regulations. A class of stock is regularly traded on an exchange during any calendar year during which such class of stock is traded, other than in de minimis quantities, on at least 15 days during each calendar quarter. To be marketable stock, our ordinary shares must be regularly traded on a qualifying exchange (i) in the United States that is registered with the SEC or a national market system established pursuant to the Exchange Act or (ii) outside the United States that is properly regulated and meets certain trading, listing, financial disclosure and other requirements. Our ordinary shares are expected to constitute “marketable stock” as long as they remain listed on the Nasdaq Capital Market and are regularly traded.

Our ordinary shares have been listed on the Nasdaq Capital Market under the symbol “GLMD” since March 13, 2014. Prior to that date, there was no public trading market for our ordinary shares.

Brusselmans, K. et al. Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. J. Clin. Invest. 111, 1519–1527 (2003).

        (a)   Designed such disclosure controls and procedures, or caused such disclosure controls and procedures to be designed under our supervision, to ensure that material information relating to the registrant, including its consolidated subsidiaries, is made known to us by others within those entities, particularly during the period in which this report is being prepared;

        During the year ended December 31, 2018 the Company recognized $2.5 million in revenue for the achievement of a pre-clinical milestone under the Merck Agreement. No revenue was recognized during the year ended December 31, 2017.