Hi Aldebaran Always a pleasure. Back to one of our prior discussions let’s say that the average lifespan is 80 ( I don’t know what it is) It’s possible that with good genes and strict lifestyle I could make it to 95 or so in pretty good health, let’s just say no major problems. I now introduce rapamycin into the equation. What now would be an acceptable result? Let’s say 100 in pretty good health. No How about 100 in really good health, vital and robust. Yes How about 105 in pretty good health? Again Yes 110 in poor health? No

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I am wondering if CRISPR technology could improve the efficiency of the therapy and reduce off-target. Also, I am wondering if this therapy reduces mTOR levels. Maybe it could also affect some epigenetic markers.

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In terms of your suggestions Paul, I’m afraid we can’t separate intermittent fasting benefits from CR, and IGF is too intertwined with MTOR for us to be confident benefits would be additive. I regard angiotensin treatment as mainly benefiting mitochondria. So it probably wouldn’t sum if you’re already doing NR or something like that.

van Berlo, J. H., Maillet, M. & Molkentin, J. D. Signaling effectors underlying pathologic growth and remodeling of the heart. J. Clin. Invest. 123, 37–45, 10.1172/JCI62839 (2013).

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The Pharma Services business of Thermo Fisher Scientific will invest $150 Million at three facilities.