Hi Paul, After 6 months on Rapamycin had decrease hemoglobin, lymphocytes and polys as reported. This due to putting brake on hematopoietic stem cells. Mild anemia very common effect. I consider this benevolent side effect and helps protect stem cells from development senescent cells which much bigger problem. So slight inhibition stem cells real and probably part of anti-aging effect.

It is believed that NDMA contamination resulted from changes that Zhejiang Huahai made to its manufacturing process in 2011 and 2012, using a method that was patented in 2014 to reduce waste and improve product yield. Zhejiang Huahai had submitted documentation for the process change to regulators, and no objections were found. “The FDA and the European Directorate for the Quality of Medicines and Healthcare (EDQM) approved the changed process, but may have missed the potential for formation of genotoxic impurities,” says Philippe André, a cGMP auditor with Qualandre, based in Zhejiang, China, who inspected the Zhejiang Huahai facility.

Rashkin, M. J., Hughes, R. M., Calloway, N. T. & Waters, M. L. Orientation and alkylation effects on cation-π interactions in aqueous solution. J. Am. Chem. Soc. 126, 13320–13325 (2004).

Since research in the 1950s first revealed their carcinogenic effects on animals (9), regulators have worked to reduce potential exposure, and efforts have helped lead to tobacco regulation (10) and regional smoking bans at offices, restaurants, and other indoor public areas in many parts of the world. Food processors have studied their generation during heat- (11) and acid-catalyzed manufacturing, and come up with alternative methods to reduce or prevent their release.

Exelixis, Inc. ( NasdaqGS: EXEL ) is a development-stage biotechnology company dedicated to the discovery and development of novel small molecule therapeutics for the treatment of cancer and other serious diseases. The company is leveraging its fully integrated drug discovery platform to fuel the growth of its development pipeline, which is primarily focused on cancer. Currently, Exelixis’ broad product pipeline includes investigational compounds in phase 3, phase 2, and phase 1 clinical development. Exelixis has established strategic corporate alliances with major pharmaceutical and biotechnology companies, including Bristol-Myers Squibb, GlaxoSmithKline, Genentech, Boehringer Ingelheim, Wyeth Pharmaceuticals, and Daiichi-Sankyo. 

Hi Heather Your IGF is probably good. Two things seem to bring it up in almost equal fashion, animal proteins and refined carbohydrates. I do eat fish and chicken but no refined carbohydrates to speak of, so maybe I should start substituting pea protein for the chicken at least. As for metformin, the more I read about it the more I like it, but I’ll start with 250mg and work my way up, while trying the b12 that you recommended. Need my insulin at 5 and IGF at 130. Keep walking fast. Highly predictive.

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A seventh family is directed to treatment for modulating gut microbiota using Aramchol This patent family includes a pending U.S. application as well as foreign patent applications in Brazil, Canada, China, Europe, Israel, Japan and Mexico. If granted and the appropriate maintenance, renewal, annuity or other governmental fees are paid, the non-extended term for this patent family is due to expire on January 19, 2037. 

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A weighted meta-regression using unrestricted maximum likelihood model was performed to assess the impact of statin dose, duration of statin therapy and baseline ADMA concentrations as potential moderator variables on the WMD in ADMA concentrations between statin and placebo group19,21.

Bio-Path Holdings, Inc. (OTC:BPTH ) is a biotechnology company focused on developing therapeutic products utilizing its proprietary liposomal delivery technology designed to systemically distribute nucleic acid drugs throughout the human body with a simple intravenous transfusion. Bio-Path’s lead product candidate, Liposomal Grb-2, is in a Phase I study for blood cancers. The Company announced its plans to conduct three Phase II clinical trials of Liposomal Grb-2 in combination with frontline therapy in AML, CML and MDS. In addition, Bio-Path plans to develop Liposomal Grb-2 for preoperative treatment and for metastasis in triple negative and inflammatory breast cancer patients. Bio-Path’s second drug candidate, also a liposomal antisense drug, is ready for the clinic where it will be evaluated in lymphoma and solid tumors. These product candidates and the delivery technology have been licensed from The University of Texas MD Anderson Cancer Center.

Changes in regulatory requirements and guidance or unanticipated events during our clinical trials may occur, which may result in necessary changes to clinical trial protocols, which could result in increased costs to us, delay our development timeline or reduce the likelihood of successful completion of our clinical trials.