Totally agree, her work is brilliant. I guess Blackburn prefers science to stay theoretical and never actually benefit anyone.

Due to Western sanctions over the Russian annexation of Crimea; long-lasting tensions over Russian support for pro-independence fighters in eastern Ukraine; Russian anger over the promotion of Color Revolutions in its backyard, especially Georgia; and Russian weapons that were allegedly involved in the shooting down of a Malaysian Airlines jetliner that had killed all onboard; Russo-EU ties are strained. Russo-US ties are also strained for the same reason but the US under the Trump administration is keen to reach rapprochement with the Russians. In fact, in his meeting with NATO allies, President Trump pushed hard for the revival of the G-8 (the G-7 plus Russia). President Trump is trying very hard to reboot American relations with the Russians, something of great significance between the world’s top two nuclear powers armed with enough ICBMs to destroy the world many times over. President Trump’s overtures are resisted by many: his Democrat colleagues, European leaders and his own intelligence services. This is a complicated situation.

Furthermore, Israeli tax considerations may make potential transactions unappealing to us or to our shareholders whose country of residence does not have a tax treaty with Israel exempting such shareholders from Israeli tax. See “Item 10. Additional Information—E. Taxation—Certain Israeli Tax Considerations” for additional information.

We have obtained insurance coverage for our clinical trials in accordance with market standards and in compliance with applicable Israeli law. However, our insurance coverage may not be sufficient to reimburse us for any expenses or losses we may suffer. Moreover, insurance coverage is becoming increasingly expensive, and, in the future, we may not be able to maintain insurance coverage at a reasonable cost or in sufficient amounts to protect us against losses due to liability. If and when we obtain marketing approval for Aramchol, or any other product candidate, we intend to expand our insurance coverage to include the sale of commercial products; however, we may be unable to obtain this product liability insurance on commercially reasonable terms. On occasion, large judgments have been awarded in class action lawsuits based on drugs that had unanticipated side effects. The cost of any product liability litigation or other proceedings, even if resolved in our favor, could be substantial. A successful product liability claim, or series of claims, brought against us could cause our share price to decline and, if judgments exceed our insurance coverage, could decrease our cash and adversely affect our business.

Hi Alan There have always been several knocks on TA 65, jusitfied or not. One is cost. They blame that on the cost of extraction. The other is efficacy in people. It seems to work somewhat in mice ( Blasco) but not like rapamycin, Also there have been actual human studies showing elongation of the critically short telomeres. The main knock is regarding safety and cancer risk mainly because scientists like Blackburn and DelPinho keep saying it, and have from the beginning. Even Vince, a very early and ardent proponent stopped it over those concerns. Do they know something? I doubt it.

To evaluate the possibility that TRPM2-mediated Ca2+ signaling is required for the antitumor effector function of NK cells, we first examined the tumor-induced Ca2+ change in NK cells from TRPM2+/+ and TRPM2−/− mice. We noticed robust Ca2+ signals in both TRPM2+/+ and TRPM2−/− NK cells upon contact with B16F10 cells, a melanoma tumor cell line. However, TRPM2+/+ NK cells were distinct from TRPM2−/− NK cells in their ability to sustain the Ca2+ signals. TRPM2+/+ NK cells exhibited a rapid initial increase, after which the elevated levels remained for the duration of our measurement (500 s). In contrast, TRPM2−/− NK cells were not able to sustain the initial intracellular [Ca2+] ([Ca2+]i) rise (Fig. 1a; 31.5% of area under curve (AUC) of Ca2+ trace in TRPM2+/+ NK cells). As [Ca2+]i increase is important to the degranulation of NK cells7, we investigated whether TRPM2 was involved in degranulation activity. We compared the surface expression of CD107a in TRPM2+/+ and TRPM2−/− NK cells following stimulation with B16F10. B16F10-induced degranulation was absent in TRPM2−/− NK cells (Fig. 1b). Tumor cell-induced granzyme B secretion and cytotoxicity were also completely absent in TRPM2−/− NK cells (Fig. 1c and d). We further evaluated the ability of TRPM2 to protect against B16F10 tumor growth in vivo. Consistent with our finding that TRPM2−/− NK cells have decreased cytolytic activity (Fig. 1d), we observed a defect in the ability of TRPM2 deficient mice to control B16F10 tumor formation and their consequent survival rates (Fig. 1e and f). These results suggest that TRPM2 channel-mediated Ca2+ signals are critical for the antitumor effect of NK cells.

China BCT Pharmacy Group, Inc (OTCBB:CNBI) is engaged in pharmaceutical distribution, pharmacy retailing, and the manufacture of pharmaceuticals products through its subsidiaries Guangxi Liuzhou Baicaotang Medicine Limited, Hefeng Pharmaceutical Co. Limited, and Guangxi Liuzhou Baicaotang Medicine Retail Limited in Guangxi province, China. It operates a large regional retail network in province, consisting of 125 directly owned retail stores in Guangxi province and currently over 8,000 products are distributed through the Company’s wholesale distribution network.

Wang, Y. et al. Bioelectric effect of a chitosan bioelectret membrane on bone regeneration in rabbit cranial defects. J. Bioact. Compat. Pol. 27, 122–132 (2012).

For example, in vitro immortalized cells gradually gain methylation, but this primarily occurs on inactive gene sites. If the area of the genome is in use then it is maintained and far more resistant to methylation and deactivation. It takes many population doublings (>100) before active sites start to get methylated (in vitro). This can explain why exercise, calorie restriction and certain supplements work – by forcing an certain cellular response that is resistance to drift.

Hi Paul, Just regarding price, availability and status of telemere related products and saying nothing about merits, my understanding is as follows: TA-65, $600 month, 250 units, food supp Other drugs that Mark has been talking about: Not on market, will require FDA approval, phase 2 human trials not yet begun; probable time to market, over 5 years, probable cost, high. Are there any other natural supp cost @ $25 a month

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