The Company is contingently liable under an unused letter of credit with a bank, related to the Company’s facility leases. Refer to Note 6, "Commitments and Contingencies." As a result, as of December 31, 2018 and 2017, the Company had restricted cash as presented in the table below, securing the letters of credit. The cash will be restricted until the termination or modification of the lease arrangement.

Cash equivalents are short-term, highly liquid investments that are readily convertible into cash with maturities of three months or less as of the date acquired.

87 Cambridge Park Drive Cambridge, Massachusetts 02140 (Address of Principal Executive Offices) (Zip Code)

Just in case you have overlooked it Josh and Greg Fahy have a published rebuttal in PNAS here: https://drive.google.com/open?id=1VcLlb0TXhlYZr38UQSgskOKm1Njva_68

Singh, I. & Kishimoto, Y. Effect of cyclodextrins on the solubilization of lignoceric acid, ceramide, and cerebroside, and on the enzymatic reactions involving these compounds. J Lipid Res 24, 662–5 (1983).

Fernandez-Velasco, M. et al. Regional distribution of hyperpolarization-activated current (If) and hyperpolarization-activated cyclic nucleotide-gated channel mRNA expression in ventricular cells from control and hypertrophied rat hearts. J Physiol 553, 395–405 (2003).

The USPTO and various foreign governmental patent agencies require compliance with a number of procedural, documentary, fee payment and other provisions during the patent process. There are situations in which noncompliance can result in abandonment or lapse of a patent or patent application, resulting in partial or complete loss of patent rights in the relevant jurisdiction. In such an event, competitors might be able to enter the market earlier than would otherwise have been the case.

Loscalzo, J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res. 88, 756–762 (2001).

This annual report contains forward-looking statements about our expectations, beliefs or intentions regarding, among other things, our product development efforts, business, financial condition, results of operations, strategies or prospects. In addition, from time to time, we or our representatives have made or may make forward-looking statements, orally or in writing. Forward-looking statements can be identified by the use of forward-looking words such as “believe,” “expect,” “intend,” “plan,” “may,” “should,” “anticipate,” “could,” “might,” “seek,” “target,” “will,” “project,” “forecast,” “continue” or their negatives or variations of these words or other comparable words or by the fact that these statements do not relate strictly to historical matters. These forward-looking statements may be included in, among other things, various filings made by us with the U.S. Securities and Exchange Commission, or the SEC, press releases or oral statements made by or with the approval of one of our authorized executive officers. Forward-looking statements relate to anticipated or expected events, activities, trends or results as of the date they are made. Because forward-looking statements relate to matters that have not yet occurred, these statements are inherently subject to risks and uncertainties that could cause our actual results to differ materially from any future results expressed or implied by the forward-looking statements. Many factors could cause our actual activities or results to differ materially from the activities and results anticipated in forward-looking statements, including, but not limited to, the factors summarized below:

Seo, B. M. et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 364, 149–155 (2004).

激素激动剂和拮抗剂占激素治疗市场的一半多，2008年是56%，销售额51亿美元。这一领域的主导产品有Casodex, Zoladex, Lupron和几种仿制版的leuprolide。由于仿制药物竞争这一市场增速放缓。自2004年以来每年增长3-4%。预计2013年销售额为54亿美元。

Following the recent pull- back and the negative commentary from the Fed in July, several biotech stocks are roaring back and some analysts are bullish again.