Research and development expenses consist primarily of costs incurred for our research activities, including development of our proprietary chemistry technology platform, and our pre-clinical and clinical candidates, which include:

Catalent announces investment for its Zydis ODT technology, offering increased drug load and taste-masking capabilities.

Examples of other PLG microparticles on the market include Risperdal Consta (risperidone for antipsychotic indications), Vivitrol (naltrexone for alcohol addiction), and Bydureon (GLP1 peptide to treat type 2 diabetes).

Under the Companies Law, a person may not acquire shares in a public company if, after the acquisition, he will hold more than 90% of the shares or more than 90% of any class of shares of that company, unless a tender offer is made to purchase all of the shares or all of the shares of the particular class. The Companies Law also provides, subject to certain exceptions, that as long as a shareholder in a public company holds more than 90% of the company’s shares or of a class of shares, that shareholder shall be precluded from purchasing any additional shares unless tendering an offer to purchase all of the outstanding shares of the company or the applicable class of the shares. If the shareholders who do not respond to or accept the offer hold less than 5% of the issued and outstanding share capital of the company or of the applicable class of the shares, and more than half of the shareholders who do not have a personal interest in the offer accept the offer, all of the shares that the acquirer offered to purchase will be transferred to the acquirer by operation of law. However, a tender offer will be accepted if the shareholders who do not accept it hold less than 2% of the issued and outstanding share capital of the company or of the applicable class of the shares.

Schroder, K. et al. Capability of differently charged plasma polymer coatings for control of tissue interactions with titanium surfaces. J. Adhes. Sci. Technol. 24, 1191–1205 (2010).

To further gain insight into the mechanisms of different treatments for CH, proteomic analysis was undertaken by two-dimensional polyacrylamide gel electrophoresis for each group. Figure 4a shows the representative images of the PhastGel Blue R stained two-dimensional gels for Sham, AAS2M, and treatments group, respectively. Noticeably, the expression levels of numerous spots altered after AAS challenge for 2 months, which was protected by different drug treatments, as justified by Image Master 2D Platinum 7. Among all of the spots, 54 spots appeared to be significantly changed. The peptides were extracted from each differentially expressed spot using in-gel trypsin digestion, and were identified using mass spectrometry (MS). The results of the MS analysis of the 54 spots were summarized in Supplementary Table S1, showing that the 54 sports were identified as 41 proteins. The biological functions of these proteins can be sorted into eight groups: oxidative stress (PTGR2, ALDR, COQ7, SODM, PDIA3, COQ9, CRYM, GPX1, ETFA, and ESTD), energy metabolism (D3ZZN, ATPA, D4AOTO, NDUAA, ECH1, PEBP1, HPRT, ALDOA, ACOT2, ENOB, IDH3B, ODPA, ACADS, ALDH2, and GUAD), chaperon (HSPB6, HSPB1, HSPB2, HSPB7, CRYAB, and HSP70), protein modification (ARHL1), inflammatory response (FIBG), ion transport (VDAC1, VDAC2, TCTP and CLIC4), apoptosis (GDIRI, FRIH, and FHIL2), and blood coagulation (ANXA5). The differentially expressed spots were circled in the image of two-dimensional gel from treatments group using different colors based on the biological function classification (Fig. 4a).

In the event of grantee’s termination prior to a vesting date by reason of such grantee’s death or disability, all of such grantee’s RSUs shall immediately become vested as of the date of such termination. In the event of a grantee’s termination for cause prior to settlement, all of such grantee’s RSUs shall immediately be forfeited for no consideration as of the date of such termination. If a grantee’s employment or service is terminated for any other reason, (1) all vesting with respect to such grantee’s RSUs shall cease, (2) all of such grantee’s unvested RSUs shall immediately be forfeited for no consideration as of the date of such termination, and (3) to the extent not already settled, all of such grantee’s vested RSUs shall be settled in accordance with the settlement schedule set forth in the applicable award agreement.

While none of our employees are party to any collective bargaining agreements or represented by any labor unions, certain provisions of the Israeli labor laws and certain collective bargaining agreements between the Histadrut (General Federation of Labor in Israel) and the Coordination Bureau of Economic Organizations (including the Industrialists’ Associations) are applicable to our employees by order of the Israel Ministry of Economics. These provisions primarily concern the length of the workday, minimum daily wages for professional workers, pension fund benefits for all employees, insurance for work-related accidents, procedures for dismissing employees, determination of severance pay and other conditions of employment. We generally provide our employees with benefits and working conditions beyond the required minimums. We have never experienced any employment-related work stoppages and believe our relationship with our employees is favorable.

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        The Company calculates basic net income (loss) per share and diluted net loss per share by dividing the net income (loss) by the weighted average number of common shares outstanding during

I agree that he needs to work with a cardiologist, to identify location and type of arrhythmia, but a cardiologist that is open and friendly to nutritional supplements.

Don’t be careful Aldebaran, we’re all just having fun here, and who knows, today’s science fiction may be tomorrow’s science.