Generally, stock will be considered marketable stock if it is “regularly traded” on a “qualified exchange” within the meaning of applicable Treasury Regulations. A class of stock is regularly traded on an exchange during any calendar year during which such class of stock is traded, other than in de minimis quantities, on at least 15 days during each calendar quarter. To be marketable stock, our ordinary shares must be regularly traded on a qualifying exchange (i) in the United States that is registered with the SEC or a national market system established pursuant to the Exchange Act or (ii) outside the United States that is properly regulated and meets certain trading, listing, financial disclosure and other requirements. Our ordinary shares are expected to constitute “marketable stock” as long as they remain listed on the Nasdaq Capital Market and are regularly traded.

Also, do you have any useful information on honokiol and magnolol, two active components of magnolia I’m looking into right now?

        Pursuant to the terms of some of our license agreements with third parties, some of our third-party licensors have the right, but not the obligation in certain circumstances to control enforcement of our licensed patents or defense of any claims asserting the invalidity of these patents. Even if we are permitted to pursue such enforcement or defense, we will require the cooperation of our licensors, and cannot guarantee that we would receive it and on what terms. We cannot be certain that our licensors will allocate sufficient resources or prioritize their or our enforcement of such patents or defense of such claims to protect our interests in the licensed patents. If we cannot obtain patent protection, or enforce existing or future patents against third parties, our competitive position and our financial condition could suffer.

Admedus Ltd.  ( ASX:AHZ.AX )  is a diversified healthcare company focused on investing in and developing next generation technologies with world class partners, acquiring strategic assets to grow its product and service offerings and expanding revenues from its existing profitable medical sales and distribution business. The Company has assets from research & development through clinical development as well as sales, marketing and distribution. Admedus is in the process of commercialising its innovative tissue engineering technology for regenerative medicine. Admedus also has a major interest in developing the next generation of vaccines with a Brisbane-based research group led by Professor Ian Frazer. The vaccine programs target disease with significant global potential such as Herpes and Human Papillomavirus.

Grosso, A. F. et al. Synergistic anti-inflammatory effect: simvastatin and pioglitazone reduce inflammatory markers of plasma and epicardial adipose tissue of coronary patients with metabolic syndrome. Diabetology & metabolic syndrome 6, 47, doi: 10.1186/1758-5996-6-47 (2014).

The weighted average grant date fair value of the options granted during the years ended December 31, 2018, 2017 and 2016 is $8.19, $4.86, and $3.76 respectively.

I was thinking about cellular senescence the other day, and it occurred to me that cells are arrested all the time, say due to replication errors, or damage from ROS. When this happens there is effectively a battle between catabolism and anabolism – AMPK and FOXO (triggering autophagy)vs. MTOR and P21 (trying to continue growth and degrading mitos further). Unless the former can hold out long enough for DNA repair to be completed the cell will permanently become senescent, and there’s no way back from that (without telomerase or epigenetic reprogramming). So we can immediately see the importance of keeping low MTOR and ROS, and high AMPK, and possibly better DNA repair too. I think this process is happening all the time, with MTOR mainly winning, and it is just the robustness of the youthful immune system that removes this constant loss of functional to senescent cells. With time this changes in favour of senescent cell accumulation, and by the time this causes inflammation to rise too high, we get stem cell and telomere dysfunction too.

        As is the case with other biopharmaceutical companies, our success is heavily dependent on intellectual property, particularly patents. Obtaining and enforcing patents in the biopharmaceutical industry involves both technological and legal complexity and is therefore costly, time consuming and inherently uncertain. Recent patent reform legislation in the U.S., including the Leahy-Smith America Invents Act, or the America Invents Act, could increase those uncertainties and costs. The America Invents Act was signed into law on September 16, 2011, and many of the substantive changes became

With a global mission, the Program for Applied Research for Fertility Regulation (PARFR) funded several contraceptive programs. One of these programs involved injectable PLG microparticles for the release of norethisterone for one month and three months. The Southern Research Institute and the University of Alabama at Birmingham performed this program. Successful preclinical work led to the preparation of norethisterone microparticles for clinical trials, which represented the first use of PLG microparticles in human clinical trials in 1981 (4).

Astrotech Corporation (NasdaqCM:ASTC) is one of the first space commerce companies and remains a strong entrepreneurial force in the aerospace industry. We are leaders in identifying, developing and marketing space technology for commercial use. 1st Detect Corporation was formed by Astrotech Corporation to develop and commercialize miniature mass spectrometer technology first developed under an agreement with NASA for use on the International Space Station (ISS). 1st Detect offers what we believe is a breakthrough miniature mass spectrometry technology that fills an unmet need by being highly accurate, rapid, lightweight, durable and cost-effective. The 1st Detect patented technologies provide a versatile platform that can be applied to many applications in the security and industrial markets including airports, border security, first responder, military, agricultural, water treatment, refineries, chemical plants, pharmaceutical manufacturing and process control.

        It is possible that defects of form or timing in the preparation or filing of our patents or patent applications may exist, or may arise in the future, for example with respect to proper priority claims, inventorship, claim scope, or requests for patent term adjustments. If we or our partners, collaborators, licensees, or licensors, whether current or future, fail to establish, maintain or protect such patents and other intellectual property rights, such rights may be reduced or eliminated. If our partners, collaborators, licensees, or licensors, are not fully cooperative or disagree with us as to the prosecution, maintenance or enforcement of any patent rights, such patent rights could be compromised. If there are material defects in the form, preparation, filing, prosecution, or enforcement of our patents or patent applications, such patents may be invalid and/or unenforceable, and such applications may never result in valid, enforceable patents. Any of these outcomes could impair our ability to prevent competition from third parties, which may have an adverse impact on our business.

        This evaluation requires subjective determinations and requires the Company to make judgments about the promised goods and services and whether such goods and services are separable from the other aspects of the contractual relationship. In determining the performance obligations, the Company evaluates certain criteria, including whether the promised good or service is capable of being distinct and whether such good or service is distinct within the context of the contract, based on consideration of the relevant facts and circumstances for each arrangement. Factors considered in this determination