We may need to maintain licenses for active ingredients from third parties to develop and commercialize some of our product candidates, which could increase our development costs and delay our ability to commercialize those product candidates.

        We utilize information technology, or IT, systems and networks to process, transmit and store electronic information in connection with our business activities. As use of digital technologies has increased, cyber incidents, including deliberate attacks and attempts to gain unauthorized access to computer systems and networks, have increased in frequency and sophistication. These threats pose a risk to the security of our systems and networks, and to the confidentiality, availability and integrity of our data. There can be no assurance that we will be successful in preventing cyber-attacks or successfully mitigating their effects. Similarly, there can be no assurance that our collaborators, CROs, third-party logistics providers, distributors and other contractors and consultants will be successful in protecting our clinical and other data that is stored on their systems. Any cyber-attack or destruction or loss of data could have a material adverse effect on our business and prospects. In addition, we may suffer reputational harm or face litigation or adverse regulatory action as a result of cyber-attacks or other data security breaches and may incur significant additional expense to implement further data protection measures.

At the end of the experimental period, the carotid arteries was immediately isolated from a rat, and cut into segments of about 20 mg/tissue. The homogenate was centrifuged at 10,000 × g for 5 min, and the supernatant was removed and extracted three times with 1.5 ml of water-saturated diethyl ether. cGMP content was measured by the equilibrated radioimmunoassay as described previously51. In brief, standards or samples were introduced in a final volume of 100 μl of 50 mM sodium acetate buffer (pH 4.8). Then, 100 μl diluted cGMP antiserum and iodinated cGMP were added in succession and incubated for 24 h at 4 °C. The bound form was separated from the free form by charcoal suspension. Results were expressed as nanomole cGMP generated per milligram of protein (nmol/mg of protein).

This is blog. It is expected people say any crazy stuff they want to. I was referring to “leaders” who get widely quoted by media.

Under the Companies Law, exculpation, indemnification and insurance of Office Holders require the approval of the remuneration committee, board of directors and, in certain circumstances, the shareholders, as described above under “Item 6—Directors, Senior Management and Employees—B. Compensation.”

We only need periodic treatments that can reset homeostasis to a more youthful level. Senolytics, lengthening telomeres and epigenetic programming all promise to do just that.

As for the other aesthetic or should I say, unaesthetic changes such as ear and nose growth due to protracted MTOR (and related hormones) activation, even rapamycin treatment will not reverse this, so the only option I can think of is surgery. So if we all live to 150, we’ll likely need to go under the knife at some point if we want to look young!

        Specifically, in order for an ANDA to be approved, the FDA must find that the generic version is identical to the RLD with respect to the active ingredients, the route of administration, the dosage form, and the strength of the drug. At the same time, the FDA must also determine that the generic drug is "bioequivalent" to the innovator drug. Under the statute, a generic drug is bioequivalent to a RLD if "the rate and extent of absorption of the drug do not show a significant difference from the rate and extent of absorption of the listed drug."

AMAG Pharmaceuticals, Inc . (NASDAQGM:AMAG ) AMAG Pharmaceuticals, Inc. is a biopharmaceutical company that utilizes its proprietary technology for the development and commercialization of a therapeutic iron compound to treat anemia and novel imaging agents to aid in the diagnosis of cancer and cardiovascular disease.

The best example is the famous J curve for alcohol in which small amounts are beneficial at low doses for the heart and huge amounts are horrible (although a recent meta-analysis has challenged this [ Lancet vol. 392 pp. 1015 – 1035 ’18 ], but I don’t trust them — for why see http://science.sciencemag.org/content/sci/361/6408/1184.full.pdf.

        4.     The registrant’s other certifying officer and I are responsible for establishing and maintaining disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e) and 15d-15(e)) and internal control over financial reporting (as defined in Exchange Act Rules 13a-15(f) and 15d-15(f)) for the registrant and have:

Marketable debt securities are considered to be available for sale and are carried at fair value. Unrealized gains and losses net of tax, if any, are reported as a separate component of stockholders’ equity. The cost of marketable debt securities classified as available for sale is adjusted for amortization of premiums and accretion of discounts to maturity. Such amortization and accretion are included in interest income. Realized gains and losses and declines in value judged to be other than temporary, if any, are also included in other income, net. Interest on securities classified as available for sale is included in interest income. The cost of securities sold is based on the specific identification method.