However I am looking to the future when we will look not only to live a long time looking almost like an marathon runner, where we are fit and healthy in spite of being old, but actually start looking young again, and having the innate health that comes from not being old (biologically). The very young often look like they are fatter, but it is really just puppy fat and is part of what makes them so healthy. They remain insulin sensitive even on a diet of junk. And they exercise only for fun, they are naturally active because it feels good to move, but they do not really need to, and it does not tire them in the same way it does later in life. This is a new avenue I think we should begin to think about and investigate and it is what I have been attempting to look into.

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The Blood Stasis Syndrome model was produced as described previously48. Briefly, rats were kept in plastic cages at 22 ± 2 °C with free access to pellet food and water and on a 12 h light/dark cycle. Rats were randomly divided into four groups (control group, model group, model +β-BA100 mg/kg and model +β-BA 200 mg/kg group) with eight animals in each. Rats were given blank solvent as the vehicle at the same volume for control group. Rats were given blank solvent at the same volume for model group. In the model +β-BA (100 mg/kg) group, rats were given 100 mg/kg β-BA. In the model +β-BA (200 mg/kg) group, rats were given 200 mg/kg β-BA. All treatments were performed by gavage and were administered seven times with an interval of 12 h. After the fifth administration, the model rats except those in control group with blood stasis were established by being placed in ice-cold water (0–2 °C) for 5 min, during the interval between two injections of adrenaline hydrochloride (0.8 mg/kg). Rats were fasted overnight and administration continued after performing the model. Blood samples and carotid artery were collected 30 min after the last administration on the following day.

Hi Mark, Anti-aging is about prevention not treatment established disease. Advice about arrhythmia is follow advice of cardiologist. If uncertain get second opinion of another cardiologist. Also worthwhile to travel 1000 miles to see leading cardiologist at best hospital.

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It is very difficult, but it is sometimes possible to protect yourself but still alert third parties to some problems. The WSJ exposed problems at Theranos (Dx, not Tx). Some legislators can be contacted.

        We do not independently conduct clinical trials of any of our product candidates. We rely on third parties, such as contract research organizations, or CROs, clinical data management organizations, medical institutions and clinical investigators, to conduct these clinical trials and expect to rely on these third parties to conduct clinical trials of any other product candidate that we develop. Any of these third parties may terminate their engagements with us under certain circumstances. We may not be able to enter into alternative arrangements or do so on commercially reasonable terms. In addition, there is a natural transition period when a new contract research organization begins work. As a result, delays would likely occur, which could negatively impact our ability to meet our expected clinical development timelines and harm our business, financial condition and prospects.

In conclusion, this meta-analysis of RCTs showed a significant reduction in plasma ADMA concentrations following hydrophilic statin therapy. These results might reveal an additional benefit of statins, which might contribute to the observed reduction of cardiovascular risk. Larger, well-designed studies involving smoking status are needed to validate our findings.

Eddy, A. A. Progression in chronic kidney disease. Advances in chronic kidney disease. 12, 353–365 (2005).

Mark suggests that much of its benefits may be from the rather potent antioxidant effect. The abstract seems to support this. Was that the bottom line?

Boswellia serrata’s gum resin is one such plant used in Indian Ayurvedic and folk medicine to treat blood disorders and curtail inflammatory diseases like rheumatoid arthritis and to promote cardiac health24,25. Present study aims to investigate the mechanism of β-BA, an active triterpenoid compound from the extract of boswellia serrate, to protect endothelial function from blood stasis. Here, β-BA’s effective protection of endothelial function against blood stasis insult is firstly explained.

“Telomerase activators have been reported (de Jesus et al, 2011; Fauce et al, 2008; Harley et al, 2011), however, their mechanism of action is still poorly understood. Instead, we turned into a TERT-based gene therapy strategy to extend longevity, to our knowledge unprecedented in the context of aging studies. “