Our executive offices are located in Tel Aviv, Israel. In addition, the majority of our officers and directors are residents of Israel. Accordingly, political, economic and military conditions in Israel may directly affect our business. Since the establishment of the State of Israel in 1948, a number of armed conflicts have taken place between Israel and its neighboring countries. Any hostilities involving Israel or the interruption or curtailment of trade between Israel and its trading partners could adversely affect our operations and results of operations. In recent years, these have included hostilities between Israel and Hezbollah in Lebanon and Hamas in the Gaza strip, both of which resulted in rockets being fired into Israel, causing casualties and disruption of economic activities. In addition, Israel faces threats from more distant neighbors, in particular, Iran.

This is not only a huge public health problem, but a fascinating issue from a scientific view-point. Although it needs to be solved, I foresee a slew of new regulations coming down on the industry, which may make it almost impossible to change a synthetic route. I’d like to believe that the FDA/EMA would propose some sensible focused regulation around this (something clearly needs to be done), but what we may end up with is a whole new regulatory morass. Have fun, chemists!

Upon the signing of the Samil Agreement, Samil paid the Company a gross upfront fee of approximately $2.1 million and in September], 2018, we received a milestone payment of $1.5 million. Samil has also agreed to pay additional clinical and regulatory-based milestone payments, which may aggregate to an additional $4.5 million, as well as tiered, double-digit royalties payable on sales (lower if sales of a generic equivalent commence in the Territory).

        If a product with orphan status receives the first FDA approval for the disease or condition for which it has such designation or for a select indication or use within the rare disease or condition for which it was designated, the product generally will be receiving orphan product exclusivity. Orphan product exclusivity means that the FDA may not approve any other applications for the same product for the same indication for seven years, except in certain limited circumstances. Competitors may receive approval of different products for the indication for which the orphan product has exclusivity and may obtain approval for the same product but for a different indication. If a drug or drug product designated as an orphan product ultimately receives marketing approval for an indication broader than what was designated in its orphan product application, it may not be entitled to exclusivity.

I do not eat flesh foods, and have not since age 16, after seeing a documentary on how they slaughter animals, so that may help keep IGF-1 lower.

        The Patient Protection and Affordable Care Act, as amended by the Health Care and Education Reconciliation Act, each as amended, or collectively the Affordable Care Act, or ACA, contains many provisions of potential importance to our business and our product candidates are the following, including among others:

Bachem supplies peptides and organic active ingredients whose patent protection has lapsed. This business segment accounts for 30% of Bachem’s sales revenue.

We are subject to extensive government regulation and the failure to comply with these regulations may have a material adverse effect on our operations and business.

The most recent PLG implant introduced on the market is Scenesse developed by Evonik for the Australian company Clinuvel Pharmaceuticals. It releases the peptide afamelanotide, a photoprotective drug that protects against sunlight damage by increasing melanin in the skin. Scenesse is indicated for the treatment of erythropoietic protoporphyria, a severe skin disorder caused by the body’s inability to protect itself from sunlight. 

Boswellia serrata’s gum resin is one such plant used in Indian Ayurvedic and folk medicine to treat blood disorders and curtail inflammatory diseases like rheumatoid arthritis and to promote cardiac health24,25. Present study aims to investigate the mechanism of β-BA, an active triterpenoid compound from the extract of boswellia serrate, to protect endothelial function from blood stasis. Here, β-BA’s effective protection of endothelial function against blood stasis insult is firstly explained.

The animals were fasted for 12 hours before experiment, while allowing free access to water. Animals were anesthetized with 2% pentobarbital sodium (60 mg/kg) by intraperitoneal injection. After tracheotomy, the animals were ventilated with a positive pressure respirator (ALC-V8, Shanghai, China). The thorax was opened and ascending aortic stenosis was implemented by placing a silver clip (0.9-mm inside diameter) on the ascending aorta. Sham-operated animals underwent an identical procedure but without the clip12.

Wei, J. H. S. S. & Yu-ping, H. Y. D. J. Effect of Extracts from Olibanum and Myrrha and Their Compatibility on Platelet Aggregation and Antithrombin Activity. Chinese Journal of Experimental Traditional Medical Formulae. 17, 160–165 (2011).