For those who like gossip.The above you tube video features Leonard Guarente, whom I have known and interviewed since 2006. As he begins his lecture he refers to two students of his at MIT, Brian Kennedy and Nic Astriaco. I have interviewed both of them. Nic left his fellowship in the UK in the 90’s after 9 months and entered the priesthood. He now teaches genetics at Providence College and also consults on the ethical issues brought up by research. His long ago partner, Brian Kennedy, was actually his mentor when he returned to research after being ordained. Kennedy recounted that first meeting “Nic came in with his clerical collar and his bible and we trashed it out, argued our positions” – all done in understatement. Guarente explained that when he told his colleagues about Nic entering the seminary, their reaction was “worse than if he had died.” Lenny and Brian have clashed over their dueling genes, srituins and mtor, on and off for years.

In 2019, we completed a PK study involving 16 healthy subjects to assess whether dose splitting of Aramchol 600mg to twice daily 300mg will significantly increase plasma levels. The treatment in both dosing regimens was similar in terms of safety and was well tolerated.

Although this study was paid for by the manufacturers for the cell type they looked at the results seem impressive. And the natural substances used all have decent bioavailability, unlike cycloastranagol.

Hi Paul, Just regarding price, availability and status of telemere related products and saying nothing about merits, my understanding is as follows: TA-65, $600 month, 250 units, food supp Other drugs that Mark has been talking about: Not on market, will require FDA approval, phase 2 human trials not yet begun; probable time to market, over 5 years, probable cost, high. Are there any other natural supp cost @ $25 a month

Statistical comparisons were performed with Student’s t–test or repeated measures ANOVA. Data are presented as the mean ± standard deviation (SD). In all cases, P values less than 0.05 were considered statistically significant.

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Girard-Lauriault, P.-L. et al. Atmospheric pressure deposition of micropatterned nitrogen-rich plasma-polymer films for tissue engineering. Plasma Process. Polym. 2, 263–270 (2005).

My thoughts on excessive high intensive exercise is that it may be the depletion of essential minerals (such as magnesium), may lead to worse health outcomes. This may be because it would then lead to poor blood sugar control. I say this because as a heavy gym user (combined with excessive alcohol use), I suffered muscle twitching and some high blood sugar episodes (resolved by giving up alcohol for a week and going low carb).

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Speaking of idiot doctors…It would be enormously helpful if people here who have doctors who are knowledgeable – or at least open – to recent aging research would consider sharing their names. My own doctor, thought not an idiot, has severe limitations (she told me that fasting more than 16 hours was dangerous and refused to look at an article about Longo). Doctors who proclaim to be anti-aging often have cheesy websites. It’s hard to find a good doctor without a trustworthy referral. Thank you, Josh, for your extraordinary site and everyone here who contributes. I’m a determined to stay healthy 65, and this site has given me enormous optimism about aging pro-actively. I am not a scientist, so a lot goes over my head, but the discussions fascinates me. Besides being beneficial for my heath, Josh’s site has made a new world of biological research accessible to me. I so appreciate having a ringside seat!

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